The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy

Detalhes bibliográficos
Autor(a) principal: Andrade, Priscila R.
Data de Publicação: 2019
Outros Autores: Mehta, Manali, Lu, Jing, Teles, Rosane M. B., Montoya, Dennis, Scumpia, Phillip O., Sarno, Euzenir Nunes, Ochoa, Maria Teresa, Ma, Feiyang, Pellegrini, Matteo, Modlin, Robert L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35530
Resumo: University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
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spelling Andrade, Priscila R.Mehta, ManaliLu, JingTeles, Rosane M. B.Montoya, DennisScumpia, Phillip O.Sarno, Euzenir NunesOchoa, Maria TeresaMa, FeiyangPellegrini, MatteoModlin, Robert L.2019-09-12T15:19:03Z2019-09-12T15:19:03Z2019ANDRADE, Priscila R. et al. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Neglected Tropical Diseases, v. 13, n. 7, p. 1-18, July 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3553010.1371/journal.pntd.00075891935-2735engPublic Library of ScienceMycobacterium lepraeRegulador do destino celularInterferon tipo IHanseníase humanaNUPR1Mycobacterium lepraeT cellRegulator NUPR1Type I InterferonHuman leprosyThe cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USAUniversity of California Los Angeles. Department of Molecular, Cell, and Developmental Biology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA.University of California Los Angeles. Department of Molecular, Cell, and Developmental Biology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.University of California Los Angeles. Department of Molecular, Cell, and Developmental Biology. Los Angeles, CA, USA.University of California Los Angeles. Department of Molecular, Cell, and Developmental Biology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA / University of California Los Angeles. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA.The initial interaction between a microbial pathogen and the host immune response influences the outcome of the battle between the host and the foreign invader. Leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, provides a model to study relevant human immune responses. Previous studies have adopted a targeted approach to investigate host response to M. leprae infection, focusing on the induction of specific molecules and pathways. By measuring the host transcriptome triggered by M. leprae infection of human macrophages, we were able to detect a host gene signature 24-48 hours after infection characterized by specific innate immune pathways involving the cell fate mechanisms autophagy and apoptosis. The top upstream regulator in the M. leprae-induced gene signature was NUPR1, which is found in the M. leprae-induced cell fate pathways. The induction of NUPR1 by M. leprae was dependent on the production of the type I interferon (IFN), IFN-β. Furthermore, NUPR1 mRNA and protein were upregulated in the skin lesions from patients with the multibacillary form of leprosy. Together, these data indicate that M. leprae induces a cell fate program which includes NUPR1 as part of the host response in the progressive form of leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35530/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEuzenirSarno_DenysMontoya_etal_IOC_2019.pdfEuzenirSarno_DenysMontoya_etal_IOC_2019.pdfapplication/pdf2326525https://www.arca.fiocruz.br/bitstream/icict/35530/2/EuzenirSarno_DenysMontoya_etal_IOC_2019.pdfcb0fb13d0a13aa42c3058a9cd664aa85MD52TEXTEuzenirSarno_DenysMontoya_etal_IOC_2019.pdf.txtEuzenirSarno_DenysMontoya_etal_IOC_2019.pdf.txtExtracted texttext/plain65137https://www.arca.fiocruz.br/bitstream/icict/35530/3/EuzenirSarno_DenysMontoya_etal_IOC_2019.pdf.txt441fd4b01ad608d3cca5580bad83c66fMD53icict/355302019-09-18 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dc.title.pt_BR.fl_str_mv The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
title The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
spellingShingle The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
Andrade, Priscila R.
Mycobacterium leprae
Regulador do destino celular
Interferon tipo I
Hanseníase humana
NUPR1
Mycobacterium leprae
T cell
Regulator NUPR1
Type I Interferon
Human leprosy
title_short The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
title_full The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
title_fullStr The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
title_full_unstemmed The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
title_sort The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
author Andrade, Priscila R.
author_facet Andrade, Priscila R.
Mehta, Manali
Lu, Jing
Teles, Rosane M. B.
Montoya, Dennis
Scumpia, Phillip O.
Sarno, Euzenir Nunes
Ochoa, Maria Teresa
Ma, Feiyang
Pellegrini, Matteo
Modlin, Robert L.
author_role author
author2 Mehta, Manali
Lu, Jing
Teles, Rosane M. B.
Montoya, Dennis
Scumpia, Phillip O.
Sarno, Euzenir Nunes
Ochoa, Maria Teresa
Ma, Feiyang
Pellegrini, Matteo
Modlin, Robert L.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Priscila R.
Mehta, Manali
Lu, Jing
Teles, Rosane M. B.
Montoya, Dennis
Scumpia, Phillip O.
Sarno, Euzenir Nunes
Ochoa, Maria Teresa
Ma, Feiyang
Pellegrini, Matteo
Modlin, Robert L.
dc.subject.other.pt_BR.fl_str_mv Mycobacterium leprae
Regulador do destino celular
Interferon tipo I
Hanseníase humana
NUPR1
topic Mycobacterium leprae
Regulador do destino celular
Interferon tipo I
Hanseníase humana
NUPR1
Mycobacterium leprae
T cell
Regulator NUPR1
Type I Interferon
Human leprosy
dc.subject.en.pt_BR.fl_str_mv Mycobacterium leprae
T cell
Regulator NUPR1
Type I Interferon
Human leprosy
description University of California Los Angeles. David Geffen School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-12T15:19:03Z
dc.date.available.fl_str_mv 2019-09-12T15:19:03Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Priscila R. et al. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Neglected Tropical Diseases, v. 13, n. 7, p. 1-18, July 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35530
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007589
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv ANDRADE, Priscila R. et al. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Neglected Tropical Diseases, v. 13, n. 7, p. 1-18, July 2019.
1935-2727
10.1371/journal.pntd.0007589
1935-2735
url https://www.arca.fiocruz.br/handle/icict/35530
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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