Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno de Bezerril
Data de Publicação: 2014
Outros Autores: Kumar, Nathella Pavan, Sridhar, Rathinam, Banurekha, Vaithilingam V, Jawahar, Mohideen S, Nutman, Thomas B, Sher, Alan, Babu, Subash
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24904
Resumo: ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Andrade, Bruno de BezerrilKumar, Nathella PavanSridhar, RathinamBanurekha, Vaithilingam VJawahar, Mohideen SNutman, Thomas BSher, AlanBabu, Subash2018-02-21T18:58:24Z2018-02-21T18:58:24Z2014ANDRADE, B. B. et al. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. Chest, v. 145, n. 6, p. 1244–1254, 2014.0012-3692https://www.arca.fiocruz.br/handle/icict/2490410.1378/chest.13-1799ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthNational Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USANational Institutes of Health. Immunobiology Section. Bethesda, MD, USAGovernment Stanley Medical Hospital. Chennai, IndiaInternational Center for Excellence in Research. Chennai, India / National Institute for Research in Tuberculosis. Chennai, IndiaInternational Center for Excellence in Research. Chennai, India / National Institute for Research in Tuberculosis. Chennai, IndiaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, MD, USANational Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USANational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, MD, USAThe increased prevalence of type 2 diabetes mellitus (T2DM) in countries endemic for TB poses a serious complication in the clinical management of this major infectious disease. Understanding the impact of T2DM on TB and the determinants of comorbidity is critical in responding to this growing public health problem with better therapeutic approaches. Here, we performed an exploratory study assessing a series of biologic parameters that could serve as markers of pathogenesis in TB with T2DM. Methods: Cross-sectional analyses of levels of heme oxygenase-1 (HO-1), acute phase proteins, tissue metalloproteinases, and tissue inhibitors of metalloproteinase (TIMPs) as well as cytokines and chemokines were performed in plasma samples from individuals with active pulmonary TB or with coincident TB and T2DM from South India. Results: Compared with patients with TB without diabetes, those with coincident T2DM exhibited increased Mycobacterium tuberculosis bacillary loads in sputum. Plasma levels of HO-1 but not of other acute phase proteins were higher in patients with TB and T2DM than in patients without diabetes, independent of bacillary sputum loads. HO-1 concentrations also positively correlated with random plasma glucose, circulating glycosylated hemoglobin, and low-density lipoprotein levels. Moreover, patients with coincident TB and T2DM exhibited increased plasma levels of TIMP-4 and elevated peripheral blood neutrophil counts, which, when considered together with HO-1, resulted in increased power to discriminate individuals with active TB with and without T2DM. Conclusions: Elevated plasma levels of HO-1 and TIMP-4 and peripheral blood neutrophil counts are potential single and combined markers of pathogenesis in TB and T2DM.engElsevierMycobacterium tuberculosisDiabetes Mellitus, Tipo 2NeutrófilosBiomarcadoresHeme Oxigenase-1Inibidores Teciduais de MetaloproteinasesHumanosMycobacterium tuberculosisDiabetes Mellitus, Type 2NeutrophilsBiomarkersHeme Oxygenase-1Tissue Inhibitor of MetalloproteinasesHumansHeightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
title Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
spellingShingle Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
Andrade, Bruno de Bezerril
Mycobacterium tuberculosis
Diabetes Mellitus, Tipo 2
Neutrófilos
Biomarcadores
Heme Oxigenase-1
Inibidores Teciduais de Metaloproteinases
Humanos
Mycobacterium tuberculosis
Diabetes Mellitus, Type 2
Neutrophils
Biomarkers
Heme Oxygenase-1
Tissue Inhibitor of Metalloproteinases
Humans
title_short Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
title_full Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
title_fullStr Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
title_full_unstemmed Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
title_sort Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity
author Andrade, Bruno de Bezerril
author_facet Andrade, Bruno de Bezerril
Kumar, Nathella Pavan
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Nutman, Thomas B
Sher, Alan
Babu, Subash
author_role author
author2 Kumar, Nathella Pavan
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Nutman, Thomas B
Sher, Alan
Babu, Subash
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno de Bezerril
Kumar, Nathella Pavan
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Nutman, Thomas B
Sher, Alan
Babu, Subash
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Diabetes Mellitus, Tipo 2
Neutrófilos
Biomarcadores
Heme Oxigenase-1
Inibidores Teciduais de Metaloproteinases
Humanos
topic Mycobacterium tuberculosis
Diabetes Mellitus, Tipo 2
Neutrófilos
Biomarcadores
Heme Oxigenase-1
Inibidores Teciduais de Metaloproteinases
Humanos
Mycobacterium tuberculosis
Diabetes Mellitus, Type 2
Neutrophils
Biomarkers
Heme Oxygenase-1
Tissue Inhibitor of Metalloproteinases
Humans
dc.subject.en.pt_BR.fl_str_mv Mycobacterium tuberculosis
Diabetes Mellitus, Type 2
Neutrophils
Biomarkers
Heme Oxygenase-1
Tissue Inhibitor of Metalloproteinases
Humans
description ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-02-21T18:58:24Z
dc.date.available.fl_str_mv 2018-02-21T18:58:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ANDRADE, B. B. et al. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. Chest, v. 145, n. 6, p. 1244–1254, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24904
dc.identifier.issn.pt_BR.fl_str_mv 0012-3692
dc.identifier.doi.none.fl_str_mv 10.1378/chest.13-1799
identifier_str_mv ANDRADE, B. B. et al. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. Chest, v. 145, n. 6, p. 1244–1254, 2014.
0012-3692
10.1378/chest.13-1799
url https://www.arca.fiocruz.br/handle/icict/24904
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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