Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17911 |
Resumo: | Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil. |
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Bernuci, Karine ZanoliIwanaga, Camila CristinaFernandez-Andrade, Carla Maria MarianoLorenzetti, Fabiana BruscoSantos, Eduardo Caio TorresFaiões, Viviane dos SantosGonçalves, José EduardoAmaral, Wanderlei doDeschamps, CíceroScodro, Regiane Bertin de LimaCardoso, Rosilene FressattiBaldin, Vanessa PietrowskiCortez, Diógenes Aparício Garcia2017-03-01T16:59:16Z2017-03-01T16:59:16Z2016BERNUCI, Karine Zanoli; et al. Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species. Molecules, v.21, n.1698, 12p, 2016.1420-3049https://www.arca.fiocruz.br/handle/icict/1791110.3390/molecules21121698engMDPIMycobacterium tuberculosisLeishmania amazonensisPiperaceaePiperaceaeGC–MSessential oilLeishmania amazonensisMycobacterium tuberculosisEvaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Speciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil.Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil.Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil.Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.UniCesumar. Mestrado em Tecnologias Limpas e Mestrado em Promoção da Saúde. Maringá, PR, Brasil / Instituto Cesumar de Ciências, Tecnologia e Inovação. Maringá, PR, Brasil.Universidade Federal do Paraná. Departamento de Fitotecnia e Fitossanitaríssimo. Setor de Ciências Agrárias. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Fitotecnia e Fitossanitaríssimo. Setor de Ciências Agrárias. Curitiba, PR, Brasil.Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil.Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil.Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil.Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil / Instituto Cesumar de Ciências, Tecnologia e Inovação. Maringá, PR, Brasil.Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC-MS), and a total of 68 components were identified. Principal components analysis results showed a chemical variability between species, with sesquiterpene compounds predominating in the majority of species analyzed. The composition of the essential oil of Piper mosenii was described for the first time. The cytotoxicity of the essential oils was evaluated in peritoneal macrophages and the oils of P. rivinoides, P. arboretum, and P. aduncum exhibited the highest values, with cytotoxic concentration at 50% (CC50) > 200 µg/mL. Both P. diospyrifolium and P. aduncum displayed activity against Leishmania amazonensis, and were more selective for the parasite than for the macrophages, with a selectivity index (SI) of 2.35 and >5.52, respectively. These SI values were greater than the 1 for the standard drug pentamidine. The antileishmanial activity of the essential oils of P. diospyrifolium and P. aduncum was described for the first time. P. rivinoides, P. cernuum, and P. diospyrifolium displayed moderate activity against the Mycobacterium tuberculosis H37Rv bacillus, with a minimum inhibitory concentration (MIC) of 125 µg/mL. These results are relevant and suggests their potential for therapeutic purposes. Nevertheless, further studies are required to explain the exact mechanism of action of these essential oils.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17911/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeduardo2_santos_etal_IOC_2016.pdfeduardo2_santos_etal_IOC_2016.pdfapplication/pdf555632https://www.arca.fiocruz.br/bitstream/icict/17911/2/eduardo2_santos_etal_IOC_2016.pdfbd65649fbdb3ef21e200cdd94e3e5cacMD52TEXTeduardo2_santos_etal_IOC_2016.pdf.txteduardo2_santos_etal_IOC_2016.pdf.txtExtracted texttext/plain46452https://www.arca.fiocruz.br/bitstream/icict/17911/3/eduardo2_santos_etal_IOC_2016.pdf.txt3e41d5e237f1b0eb778d7de66ebc1ce3MD53icict/179112018-08-15 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| dc.title.pt_BR.fl_str_mv |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| title |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| spellingShingle |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species Bernuci, Karine Zanoli Mycobacterium tuberculosis Leishmania amazonensis Piperaceae Piperaceae GC–MS essential oil Leishmania amazonensis Mycobacterium tuberculosis |
| title_short |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| title_full |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| title_fullStr |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| title_full_unstemmed |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| title_sort |
Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species |
| author |
Bernuci, Karine Zanoli |
| author_facet |
Bernuci, Karine Zanoli Iwanaga, Camila Cristina Fernandez-Andrade, Carla Maria Mariano Lorenzetti, Fabiana Brusco Santos, Eduardo Caio Torres Faiões, Viviane dos Santos Gonçalves, José Eduardo Amaral, Wanderlei do Deschamps, Cícero Scodro, Regiane Bertin de Lima Cardoso, Rosilene Fressatti Baldin, Vanessa Pietrowski Cortez, Diógenes Aparício Garcia |
| author_role |
author |
| author2 |
Iwanaga, Camila Cristina Fernandez-Andrade, Carla Maria Mariano Lorenzetti, Fabiana Brusco Santos, Eduardo Caio Torres Faiões, Viviane dos Santos Gonçalves, José Eduardo Amaral, Wanderlei do Deschamps, Cícero Scodro, Regiane Bertin de Lima Cardoso, Rosilene Fressatti Baldin, Vanessa Pietrowski Cortez, Diógenes Aparício Garcia |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bernuci, Karine Zanoli Iwanaga, Camila Cristina Fernandez-Andrade, Carla Maria Mariano Lorenzetti, Fabiana Brusco Santos, Eduardo Caio Torres Faiões, Viviane dos Santos Gonçalves, José Eduardo Amaral, Wanderlei do Deschamps, Cícero Scodro, Regiane Bertin de Lima Cardoso, Rosilene Fressatti Baldin, Vanessa Pietrowski Cortez, Diógenes Aparício Garcia |
| dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Leishmania amazonensis Piperaceae |
| topic |
Mycobacterium tuberculosis Leishmania amazonensis Piperaceae Piperaceae GC–MS essential oil Leishmania amazonensis Mycobacterium tuberculosis |
| dc.subject.en.pt_BR.fl_str_mv |
Piperaceae GC–MS essential oil Leishmania amazonensis Mycobacterium tuberculosis |
| description |
Universidade Estadual de Maringá. Programa de Pós-Graduação em Ciências Farmacêuticas. Maringá, PR, Brasil. |
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2016 |
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2016 |
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2017-03-01T16:59:16Z |
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2017-03-01T16:59:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BERNUCI, Karine Zanoli; et al. Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species. Molecules, v.21, n.1698, 12p, 2016. |
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https://www.arca.fiocruz.br/handle/icict/17911 |
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1420-3049 |
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10.3390/molecules21121698 |
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BERNUCI, Karine Zanoli; et al. Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species. Molecules, v.21, n.1698, 12p, 2016. 1420-3049 10.3390/molecules21121698 |
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