Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum

Detalhes bibliográficos
Autor(a) principal: Marques,André Mesquita
Data de Publicação: 2011
Outros Autores: Barreto,Anna Léa Silva, Curvelo,José Alexandre da R., Romanos,Maria Teresa Villela, Soares,Rosangela M. de A., Kaplan,Maria Auxiliadora C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500019
Resumo: Leishmaniasis is one of the most neglected tropical diseases, representing a group of parasitic diseases worldwide spread, occurring in 88 tropical and subtropical countries. Approximately 350 million people live in areas of active transmission of leishmaniasis, with about 1-2 million estimated new cases occurring every year. More than 90% of the cutaneous cases appear in developing countries. Efforts to improve the therapeutic arsenal against leishmaniasis have led to the search for new and cheap range of drugs. In this study, the nerolidol-rich essential oil from Piper claussenianum (Miq.) C. DC., Piperaceae, was assayed on arginase activity of Leishmania amazonensis. The effect of this essential oil on arginase activity levels showed an enzyme inhibition of 62.2%. This result stimulates the scientific interest about the potential value of this plant species on neglected diseases as potential new natural product source of pharmacological interest for the treatment of leishmaniasis.
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spelling Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianumessential oilLeishmaniaamazonensisnerolidolPiper claussenianumLeishmaniasis is one of the most neglected tropical diseases, representing a group of parasitic diseases worldwide spread, occurring in 88 tropical and subtropical countries. Approximately 350 million people live in areas of active transmission of leishmaniasis, with about 1-2 million estimated new cases occurring every year. More than 90% of the cutaneous cases appear in developing countries. Efforts to improve the therapeutic arsenal against leishmaniasis have led to the search for new and cheap range of drugs. In this study, the nerolidol-rich essential oil from Piper claussenianum (Miq.) C. DC., Piperaceae, was assayed on arginase activity of Leishmania amazonensis. The effect of this essential oil on arginase activity levels showed an enzyme inhibition of 62.2%. This result stimulates the scientific interest about the potential value of this plant species on neglected diseases as potential new natural product source of pharmacological interest for the treatment of leishmaniasis.Sociedade Brasileira de Farmacognosia2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500019Revista Brasileira de Farmacognosia v.21 n.5 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000157info:eu-repo/semantics/openAccessMarques,André MesquitaBarreto,Anna Léa SilvaCurvelo,José Alexandre da R.Romanos,Maria Teresa VillelaSoares,Rosangela M. de A.Kaplan,Maria Auxiliadora C.eng2011-09-23T00:00:00Zoai:scielo:S0102-695X2011000500019Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-09-23T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
title Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
spellingShingle Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
Marques,André Mesquita
essential oil
Leishmania
amazonensis
nerolidol
Piper claussenianum
title_short Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
title_full Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
title_fullStr Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
title_full_unstemmed Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
title_sort Antileishmanial activity of nerolidol-rich essential oil from Piper claussenianum
author Marques,André Mesquita
author_facet Marques,André Mesquita
Barreto,Anna Léa Silva
Curvelo,José Alexandre da R.
Romanos,Maria Teresa Villela
Soares,Rosangela M. de A.
Kaplan,Maria Auxiliadora C.
author_role author
author2 Barreto,Anna Léa Silva
Curvelo,José Alexandre da R.
Romanos,Maria Teresa Villela
Soares,Rosangela M. de A.
Kaplan,Maria Auxiliadora C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marques,André Mesquita
Barreto,Anna Léa Silva
Curvelo,José Alexandre da R.
Romanos,Maria Teresa Villela
Soares,Rosangela M. de A.
Kaplan,Maria Auxiliadora C.
dc.subject.por.fl_str_mv essential oil
Leishmania
amazonensis
nerolidol
Piper claussenianum
topic essential oil
Leishmania
amazonensis
nerolidol
Piper claussenianum
description Leishmaniasis is one of the most neglected tropical diseases, representing a group of parasitic diseases worldwide spread, occurring in 88 tropical and subtropical countries. Approximately 350 million people live in areas of active transmission of leishmaniasis, with about 1-2 million estimated new cases occurring every year. More than 90% of the cutaneous cases appear in developing countries. Efforts to improve the therapeutic arsenal against leishmaniasis have led to the search for new and cheap range of drugs. In this study, the nerolidol-rich essential oil from Piper claussenianum (Miq.) C. DC., Piperaceae, was assayed on arginase activity of Leishmania amazonensis. The effect of this essential oil on arginase activity levels showed an enzyme inhibition of 62.2%. This result stimulates the scientific interest about the potential value of this plant species on neglected diseases as potential new natural product source of pharmacological interest for the treatment of leishmaniasis.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000157
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.5 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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collection Revista Brasileira de Farmacognosia (Online)
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