Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics

Detalhes bibliográficos
Autor(a) principal: Grosche, Victória Riquena
Data de Publicação: 2021
Outros Autores: Santos, Igor Andrade, Ferreira, Giulia Magalhães, Dutra, João Victor Rodrigues, Costa, Larissa Catharina, Nicolau Junior, Nilson, Queiroz, Artur Trancoso Lopo, José, Diego Pandeló, Jardim, Ana Carolina Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50196
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development).
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spelling Grosche, Victória RiquenaSantos, Igor AndradeFerreira, Giulia MagalhãesDutra, João Victor RodriguesCosta, Larissa CatharinaNicolau Junior, NilsonQueiroz, Artur Trancoso LopoJosé, Diego PandelóJardim, Ana Carolina Gomes2021-12-07T12:20:14Z2021-12-07T12:20:14Z2021GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021.2057-5858https://www.arca.fiocruz.br/handle/icict/5019610.1099/mgen.0.000656Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development).São Paulo State University. São José do Rio Preto, SP, Brazil / Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Triângulo Mineiro. Campus Universitário Iturama. Iturama, MG, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Federal University of Triângulo Mineiro. Campus Universitário Iturama. Iturama, MG, Brazil.São Paulo State University. São José do Rio Preto, SP, Brazil / Federal University of Uberlândia. Uberlândia, MG, Brazil.Since the beginning of the SARS-CoV- 2 spread in Brazil, few studies have been published analysing the variability of viral genome. Herein, we described the dynamic of SARS-CoV- 2 strains circulating in Brazil from May to September 2020, to better understand viral changes that may affect the ongoing pandemic. Our data demonstrate that some of the mutations identified are currently observed in variants of interest and variants of concern, and emphasize the importance of studying previous periods in order to comprehend the emergence of new variants. From 720 SARS-CoV- 2 genome sequences, we found few sites under positive selection pressure, such as the D614G (98.5 %) in the spike, that has replaced the old variant; the V1167F in the spike (41 %), identified in the P.2 variant that emerged from Brazil during the period of analysis; and I292T (39 %) in the N protein. There were a few alterations in the UTRs, which was expected, however, our data suggest that the emergence of new variants was not influenced by mutations in UTR regions, since it maintained its conformational structure in most analysed sequences. In phylogenetic analysis, the spread of SARS-CoV- 2 from the large urban centres to the countryside during these months could be explained by the flexibilization of social isolation measures and also could be associated with possible new waves of infection. These results allow a better understanding of SARS-CoV- 2 strains that have circulated in Brazil, and thus, with relevant infomation, provide the potential viral changes that may have affected and/or contributed to the current and future scenario of the COVID-19 pandemic.engMicrobiology SocietyCOVID-19EpidmiologiaGenomaSARS-CoV- 2PandemiaCOVID-19EpidemiologyGenomic sequence analysisSARS-CoV- 2UTRInsights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50196/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGrosche Victoria Riquena Insigths....pdfGrosche Victoria Riquena 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dc.title.pt_BR.fl_str_mv Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
title Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
spellingShingle Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
Grosche, Victória Riquena
COVID-19
Epidmiologia
Genoma
SARS-CoV- 2
Pandemia
COVID-19
Epidemiology
Genomic sequence analysis
SARS-CoV- 2
UTR
title_short Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
title_full Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
title_fullStr Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
title_full_unstemmed Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
title_sort Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
author Grosche, Victória Riquena
author_facet Grosche, Victória Riquena
Santos, Igor Andrade
Ferreira, Giulia Magalhães
Dutra, João Victor Rodrigues
Costa, Larissa Catharina
Nicolau Junior, Nilson
Queiroz, Artur Trancoso Lopo
José, Diego Pandeló
Jardim, Ana Carolina Gomes
author_role author
author2 Santos, Igor Andrade
Ferreira, Giulia Magalhães
Dutra, João Victor Rodrigues
Costa, Larissa Catharina
Nicolau Junior, Nilson
Queiroz, Artur Trancoso Lopo
José, Diego Pandeló
Jardim, Ana Carolina Gomes
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grosche, Victória Riquena
Santos, Igor Andrade
Ferreira, Giulia Magalhães
Dutra, João Victor Rodrigues
Costa, Larissa Catharina
Nicolau Junior, Nilson
Queiroz, Artur Trancoso Lopo
José, Diego Pandeló
Jardim, Ana Carolina Gomes
dc.subject.other.pt_BR.fl_str_mv COVID-19
Epidmiologia
Genoma
SARS-CoV- 2
Pandemia
topic COVID-19
Epidmiologia
Genoma
SARS-CoV- 2
Pandemia
COVID-19
Epidemiology
Genomic sequence analysis
SARS-CoV- 2
UTR
dc.subject.en.pt_BR.fl_str_mv COVID-19
Epidemiology
Genomic sequence analysis
SARS-CoV- 2
UTR
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-07T12:20:14Z
dc.date.available.fl_str_mv 2021-12-07T12:20:14Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50196
dc.identifier.issn.pt_BR.fl_str_mv 2057-5858
dc.identifier.doi.none.fl_str_mv 10.1099/mgen.0.000656
identifier_str_mv GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021.
2057-5858
10.1099/mgen.0.000656
url https://www.arca.fiocruz.br/handle/icict/50196
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50196/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50196/2/Grosche%20Victoria%20Riquena%20Insigths....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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