Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50196 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development). |
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Grosche, Victória RiquenaSantos, Igor AndradeFerreira, Giulia MagalhãesDutra, João Victor RodriguesCosta, Larissa CatharinaNicolau Junior, NilsonQueiroz, Artur Trancoso LopoJosé, Diego PandelóJardim, Ana Carolina Gomes2021-12-07T12:20:14Z2021-12-07T12:20:14Z2021GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021.2057-5858https://www.arca.fiocruz.br/handle/icict/5019610.1099/mgen.0.000656Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development).São Paulo State University. São José do Rio Preto, SP, Brazil / Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Federal University of Triângulo Mineiro. Campus Universitário Iturama. Iturama, MG, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Federal University of Uberlândia. Uberlândia, MG, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Federal University of Triângulo Mineiro. Campus Universitário Iturama. Iturama, MG, Brazil.São Paulo State University. São José do Rio Preto, SP, Brazil / Federal University of Uberlândia. Uberlândia, MG, Brazil.Since the beginning of the SARS-CoV- 2 spread in Brazil, few studies have been published analysing the variability of viral genome. Herein, we described the dynamic of SARS-CoV- 2 strains circulating in Brazil from May to September 2020, to better understand viral changes that may affect the ongoing pandemic. Our data demonstrate that some of the mutations identified are currently observed in variants of interest and variants of concern, and emphasize the importance of studying previous periods in order to comprehend the emergence of new variants. From 720 SARS-CoV- 2 genome sequences, we found few sites under positive selection pressure, such as the D614G (98.5 %) in the spike, that has replaced the old variant; the V1167F in the spike (41 %), identified in the P.2 variant that emerged from Brazil during the period of analysis; and I292T (39 %) in the N protein. There were a few alterations in the UTRs, which was expected, however, our data suggest that the emergence of new variants was not influenced by mutations in UTR regions, since it maintained its conformational structure in most analysed sequences. In phylogenetic analysis, the spread of SARS-CoV- 2 from the large urban centres to the countryside during these months could be explained by the flexibilization of social isolation measures and also could be associated with possible new waves of infection. These results allow a better understanding of SARS-CoV- 2 strains that have circulated in Brazil, and thus, with relevant infomation, provide the potential viral changes that may have affected and/or contributed to the current and future scenario of the COVID-19 pandemic.engMicrobiology SocietyCOVID-19EpidmiologiaGenomaSARS-CoV- 2PandemiaCOVID-19EpidemiologyGenomic sequence analysisSARS-CoV- 2UTRInsights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50196/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGrosche Victoria Riquena Insigths....pdfGrosche Victoria Riquena Insigths....pdfapplication/pdf3021927https://www.arca.fiocruz.br/bitstream/icict/50196/2/Grosche%20Victoria%20Riquena%20Insigths....pdf3ee410cffb388c8fa6beb91a4979bd18MD52icict/501962023-03-15 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dc.title.pt_BR.fl_str_mv |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
title |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
spellingShingle |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics Grosche, Victória Riquena COVID-19 Epidmiologia Genoma SARS-CoV- 2 Pandemia COVID-19 Epidemiology Genomic sequence analysis SARS-CoV- 2 UTR |
title_short |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
title_full |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
title_fullStr |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
title_full_unstemmed |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
title_sort |
Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics |
author |
Grosche, Victória Riquena |
author_facet |
Grosche, Victória Riquena Santos, Igor Andrade Ferreira, Giulia Magalhães Dutra, João Victor Rodrigues Costa, Larissa Catharina Nicolau Junior, Nilson Queiroz, Artur Trancoso Lopo José, Diego Pandeló Jardim, Ana Carolina Gomes |
author_role |
author |
author2 |
Santos, Igor Andrade Ferreira, Giulia Magalhães Dutra, João Victor Rodrigues Costa, Larissa Catharina Nicolau Junior, Nilson Queiroz, Artur Trancoso Lopo José, Diego Pandeló Jardim, Ana Carolina Gomes |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Grosche, Victória Riquena Santos, Igor Andrade Ferreira, Giulia Magalhães Dutra, João Victor Rodrigues Costa, Larissa Catharina Nicolau Junior, Nilson Queiroz, Artur Trancoso Lopo José, Diego Pandeló Jardim, Ana Carolina Gomes |
dc.subject.other.pt_BR.fl_str_mv |
COVID-19 Epidmiologia Genoma SARS-CoV- 2 Pandemia |
topic |
COVID-19 Epidmiologia Genoma SARS-CoV- 2 Pandemia COVID-19 Epidemiology Genomic sequence analysis SARS-CoV- 2 UTR |
dc.subject.en.pt_BR.fl_str_mv |
COVID-19 Epidemiology Genomic sequence analysis SARS-CoV- 2 UTR |
description |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brazil – Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics – Finance Code No. 88881.506794/2020–01 and CAPES – Finance code 001. V.R.G. and G.M.F. received the PhD scholarship (No. 88887.505971/2020–00 and No. 88887.571465/2020–00) from CAPES, and IAS (No. 142495/2020–4) from the CNPq (National Councel of Technological and Scientific Development). |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-07T12:20:14Z |
dc.date.available.fl_str_mv |
2021-12-07T12:20:14Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50196 |
dc.identifier.issn.pt_BR.fl_str_mv |
2057-5858 |
dc.identifier.doi.none.fl_str_mv |
10.1099/mgen.0.000656 |
identifier_str_mv |
GROSCHE, Victória Riquena et al. Insights on the SARS-CoV- 2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics. Microbial Genomics, 2021. 2057-5858 10.1099/mgen.0.000656 |
url |
https://www.arca.fiocruz.br/handle/icict/50196 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Microbiology Society |
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Microbiology Society |
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