Biomphalaria glabrata immunity: Post-genome advances

Detalhes bibliográficos
Autor(a) principal: Castillo, Maria G.
Data de Publicação: 2020
Outros Autores: Humphries, Judith E, Mourão, Marina Moraes, Marquez, Joshua, Gonzalez, Adrian, Montelongo, Cesar E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58458
Resumo: NATIONAL INSTITUTES OF HEALTH
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spelling Castillo, Maria G.Humphries, Judith EMourão, Marina MoraesMarquez, JoshuaGonzalez, AdrianMontelongo, Cesar E2023-05-17T13:53:35Z2023-05-17T13:53:35Z2020CASTILLO, Maria G et al. Biomphalaria glabrata immunity: Post-genome advances. Dev Comp Immunol., v. 104, 103557, 2020. doi: 10.1016/j.dci.2019.103557.0145-305Xhttps://www.arca.fiocruz.br/handle/icict/5845810.1016/j.dci.2019.103557NATIONAL INSTITUTES OF HEALTHDepartment of Biology. New Mexico State University. Las Cruces, NM, USA.Department of Biology. Lawrence University. Appleton, WI, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Department of Biology. New Mexico State University. Las Cruces, NM, USA.Department of Biology. New Mexico State University. Las Cruces, NM, USA.Department of Biology. New Mexico State University. Las Cruces, NM, USA.The freshwater snail, Biomphalaria glabrata, is an important intermediate host in the life cycle for the human parasite Schistosoma mansoni, the causative agent of schistosomiasis. Current treatment and prevention strategies have not led to a significant decrease in disease transmission. However, the genome of B. glabrata was recently sequenced to provide additional resources to further our understanding of snail biology. This review presents an overview of recently published, postgenome studies related to the topic of snail immunity. Many of these reports expand on findings originated from the genome characterization. These novel studies include a complementary gene linkage map, analysis of the genome of the B. glabrata embryonic (Bge) cell line, as well as transcriptomic and proteomic studies looking at snail-parasite interactions and innate immune memory responses towards schistosomes. Also included are biochemical investigations on snail pheromones, neuropeptides, and attractants, as well as studies investigating the frontiers of molluscan epigenetics and cell signaling were also included. Findings support the current hypotheses on snail-parasite strain compatibility, and that snail host resistance to schistosome infection is dependent not only on genetics and expression, but on the ability to form multimeric molecular complexes in a timely and tissue-specific manner. The relevance of cell immunity is reinforced, while the importance of humoral factors, especially for secondary infections, is supported. Overall, these studies reflect an improved understanding on the diversity, specificity, and complexity of molluscan immune systems.engElsevier ScienceBiomphalaria glabrata immunity: Post-genome advancesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBiomphalaria glabrata immunity_ Post-genome advances _ Elsevier Enhanced Reader.pdfBiomphalaria glabrata immunity_ Post-genome advances _ Elsevier Enhanced Reader.pdfapplication/pdf19103454https://www.arca.fiocruz.br/bitstream/icict/58458/2/Biomphalaria%20glabrata%20immunity_%20Post-genome%20advances%20_%20Elsevier%20Enhanced%20Reader.pdf94e6eef8f0461dc6052dd00ab663dd1bMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58458/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584582023-05-17 10:53:36.23oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-17T13:53:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Biomphalaria glabrata immunity: Post-genome advances
title Biomphalaria glabrata immunity: Post-genome advances
spellingShingle Biomphalaria glabrata immunity: Post-genome advances
Castillo, Maria G.
title_short Biomphalaria glabrata immunity: Post-genome advances
title_full Biomphalaria glabrata immunity: Post-genome advances
title_fullStr Biomphalaria glabrata immunity: Post-genome advances
title_full_unstemmed Biomphalaria glabrata immunity: Post-genome advances
title_sort Biomphalaria glabrata immunity: Post-genome advances
author Castillo, Maria G.
author_facet Castillo, Maria G.
Humphries, Judith E
Mourão, Marina Moraes
Marquez, Joshua
Gonzalez, Adrian
Montelongo, Cesar E
author_role author
author2 Humphries, Judith E
Mourão, Marina Moraes
Marquez, Joshua
Gonzalez, Adrian
Montelongo, Cesar E
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Castillo, Maria G.
Humphries, Judith E
Mourão, Marina Moraes
Marquez, Joshua
Gonzalez, Adrian
Montelongo, Cesar E
description NATIONAL INSTITUTES OF HEALTH
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-05-17T13:53:35Z
dc.date.available.fl_str_mv 2023-05-17T13:53:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTILLO, Maria G et al. Biomphalaria glabrata immunity: Post-genome advances. Dev Comp Immunol., v. 104, 103557, 2020. doi: 10.1016/j.dci.2019.103557.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58458
dc.identifier.issn.en_US.fl_str_mv 0145-305X
dc.identifier.doi.none.fl_str_mv 10.1016/j.dci.2019.103557
identifier_str_mv CASTILLO, Maria G et al. Biomphalaria glabrata immunity: Post-genome advances. Dev Comp Immunol., v. 104, 103557, 2020. doi: 10.1016/j.dci.2019.103557.
0145-305X
10.1016/j.dci.2019.103557
url https://www.arca.fiocruz.br/handle/icict/58458
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
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