Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)

Detalhes bibliográficos
Autor(a) principal: Pereira, Felicidade Mota
Data de Publicação: 2021
Outros Autores: Ramos, Pablo Ivan Pereira, Lirio, Monique, Atta, Ajax Mercês, Oliveira, Isabela Silva de, Nascimento, Fabio Carneiro Vosqui, Silva, Marcelo Costa, Castro Filho, Bernardo Galvão, Grassi, Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46776
Resumo: Coordination of Superior Level Staff Improvement – Brazil (CAPES) – Finance Code 001 and National Foundation for the Development of Private Higher Education (FUNADESP), grants 9600140, and 9600141. MG and BG-C are research fellows of CNPq (process nos. 304811/2017-3s and 311054/2014-5, respectively).
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spelling Pereira, Felicidade MotaRamos, Pablo Ivan PereiraLirio, MoniqueAtta, Ajax MercêsOliveira, Isabela Silva deNascimento, Fabio Carneiro VosquiSilva, Marcelo CostaCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2021-04-20T12:24:37Z2021-04-20T12:24:37Z2021PEREIRA, Felicidade Mota et al. Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV). Frontiers in Microbiology, fev. 2021.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/4677610.3389/fmicb.2021.632695Coordination of Superior Level Staff Improvement – Brazil (CAPES) – Finance Code 001 and National Foundation for the Development of Private Higher Education (FUNADESP), grants 9600140, and 9600141. MG and BG-C are research fellows of CNPq (process nos. 304811/2017-3s and 311054/2014-5, respectively).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Secretaria da Saúde do Estado da Bahia. Laboratório Central de Saúde Pública Prof. Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Feira de Santana. Feira de Santana, BA, Brasil.Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Co-infection between the human T-cell lymphotropic virus (HTLV) and the hepatitis C virus (HCV) can modify the natural history of HCV infection. The aim of this study was to describe the inflammatory cytokines and IL-10 network in patients co-infected with HTLV and HCV viruses in Bahia, Brazil. Methods: Samples from 31 HTLV/HCV co-infected individuals and 27 HCV monoinfected individuals were evaluated. IFN-g, TNF-a, IL-10, IL-8, and IL-1 cytokines were quantified by ELISA. Clinical, laboratory data were obtained from patient records. Serum levels of the cytokines were log10-transformed and data mining was performed using Z-score statistics and correlation analysis. Results: Co-infected individuals presented a tendency toward higher production of INF- g compared to the HCV monoinfected group. Regarding cytokine pairs, there was a positive correlation (P-value < 0.05) between IL-1 and IL-8 in the HTLV/HCV co-infected group and uninfected controls, and two correlations in the HCV mono-infected group IL-8 – IL10 and IL- INF-g – IL-10 pairs. There was no significant difference between the groups for the other parameters analyzed. Conclusion: The results presented herein indicated that HTLV/HCV co-infection was associated with a trend in IFN-g production while HCV-infected individuals presented a positive correlation with both inflammatory cytokines (IL-8 and IFN-g) and the regulatory cytokine IL-10.engFrontiers MediaHTLVHepacivirusCoinfecçãoCitocinasHTLVHCVCo-infectionNetworkCytokinesEvaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46776/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALPereira, Felicidade Mota. Evaluation....pdfPereira, Felicidade Mota. 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dc.title.pt_BR.fl_str_mv Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
title Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
spellingShingle Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
Pereira, Felicidade Mota
HTLV
Hepacivirus
Coinfecção
Citocinas
HTLV
HCV
Co-infection
Network
Cytokines
title_short Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
title_full Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
title_fullStr Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
title_full_unstemmed Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
title_sort Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV)
author Pereira, Felicidade Mota
author_facet Pereira, Felicidade Mota
Ramos, Pablo Ivan Pereira
Lirio, Monique
Atta, Ajax Mercês
Oliveira, Isabela Silva de
Nascimento, Fabio Carneiro Vosqui
Silva, Marcelo Costa
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author_role author
author2 Ramos, Pablo Ivan Pereira
Lirio, Monique
Atta, Ajax Mercês
Oliveira, Isabela Silva de
Nascimento, Fabio Carneiro Vosqui
Silva, Marcelo Costa
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Felicidade Mota
Ramos, Pablo Ivan Pereira
Lirio, Monique
Atta, Ajax Mercês
Oliveira, Isabela Silva de
Nascimento, Fabio Carneiro Vosqui
Silva, Marcelo Costa
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
dc.subject.other.pt_BR.fl_str_mv HTLV
Hepacivirus
Coinfecção
Citocinas
topic HTLV
Hepacivirus
Coinfecção
Citocinas
HTLV
HCV
Co-infection
Network
Cytokines
dc.subject.en.pt_BR.fl_str_mv HTLV
HCV
Co-infection
Network
Cytokines
description Coordination of Superior Level Staff Improvement – Brazil (CAPES) – Finance Code 001 and National Foundation for the Development of Private Higher Education (FUNADESP), grants 9600140, and 9600141. MG and BG-C are research fellows of CNPq (process nos. 304811/2017-3s and 311054/2014-5, respectively).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-20T12:24:37Z
dc.date.available.fl_str_mv 2021-04-20T12:24:37Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Felicidade Mota et al. Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV). Frontiers in Microbiology, fev. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46776
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2021.632695
identifier_str_mv PEREIRA, Felicidade Mota et al. Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV). Frontiers in Microbiology, fev. 2021.
1664-302X
10.3389/fmicb.2021.632695
url https://www.arca.fiocruz.br/handle/icict/46776
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/46776/3/Pereira%2c%20Felicidade%20Mota.%20Evaluation....pdf.txt
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