Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors

Detalhes bibliográficos
Autor(a) principal: Carvalho Filho, Edgar Marcelino de
Data de Publicação: 2001
Outros Autores: Porto, Maria Aurélia da Fonseca, Bacellar, Maria Olívia Amado Ramos, Braga, Silvane, Castro, Bernardo Galvão, Neva, Franklin A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/4834
Resumo: p. 1-6
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spelling Carvalho Filho, Edgar Marcelino dePorto, Maria Aurélia da FonsecaBacellar, Maria Olívia Amado RamosBraga, SilvaneCastro, Bernardo GalvãoNeva, Franklin A.Carvalho Filho, Edgar Marcelino dePorto, Maria Aurélia da FonsecaBacellar, Maria Olívia Amado RamosBraga, SilvaneCastro, Bernardo GalvãoNeva, Franklin A.2011-12-13T15:48:38Z2011-12-13T15:48:38Z20011077-945http://www.repositorio.ufba.br/ri/handle/ri/483427(1)p. 1-6The modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-γ (IFN-γ) and the role of exogenous interleukin (IL)-10 in downregulating IFN-γ production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-γ, tumor necrosis factor-α, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-γ production, depletion of CD4+ T cells significantly decreased IFN-γ production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-γ producti on, although at high concentrations (100 ng/ml), IL-10 decreased IFN-γ production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-γ production in these patients.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-12-13T15:48:37Z No. of bitstreams: 1 Cytokine Profile.pdf: 138406 bytes, checksum: 05a3ef2c66c9aa609e62c6a8393b1a38 (MD5)Made available in DSpace on 2011-12-13T15:48:38Z (GMT). No. of bitstreams: 1 Cytokine Profile.pdf: 138406 bytes, checksum: 05a3ef2c66c9aa609e62c6a8393b1a38 (MD5) Previous issue date: 2001Cellular immunity in HTLV-1Cytokines in HTLV-1HTLV-1Immune response in HTLV-1Immunomodulation in HTLV-1Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood DonorsJournal of acquired immune deficiency syndromes and human retrovirologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALCytokine Profile.pdfCytokine Profile.pdfapplication/pdf138406https://repositorio.ufba.br/bitstream/ri/4834/1/Cytokine%20Profile.pdf05a3ef2c66c9aa609e62c6a8393b1a38MD51LICENSElicense.txtlicense.txttext/plain1748https://repositorio.ufba.br/bitstream/ri/4834/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTCytokine Profile.pdf.txtCytokine Profile.pdf.txtExtracted texttext/plain23359https://repositorio.ufba.br/bitstream/ri/4834/3/Cytokine%20Profile.pdf.txt7c6c2b8378a75666c55122316d0531b4MD53ri/48342022-07-05 14:03:17.577oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
dc.title.alternative.pt_BR.fl_str_mv Journal of acquired immune deficiency syndromes and human retrovirology
title Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
spellingShingle Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
Carvalho Filho, Edgar Marcelino de
Cellular immunity in HTLV-1
Cytokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
title_short Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
title_full Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
title_fullStr Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
title_full_unstemmed Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
title_sort Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors
author Carvalho Filho, Edgar Marcelino de
author_facet Carvalho Filho, Edgar Marcelino de
Porto, Maria Aurélia da Fonseca
Bacellar, Maria Olívia Amado Ramos
Braga, Silvane
Castro, Bernardo Galvão
Neva, Franklin A.
author_role author
author2 Porto, Maria Aurélia da Fonseca
Bacellar, Maria Olívia Amado Ramos
Braga, Silvane
Castro, Bernardo Galvão
Neva, Franklin A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho Filho, Edgar Marcelino de
Porto, Maria Aurélia da Fonseca
Bacellar, Maria Olívia Amado Ramos
Braga, Silvane
Castro, Bernardo Galvão
Neva, Franklin A.
Carvalho Filho, Edgar Marcelino de
Porto, Maria Aurélia da Fonseca
Bacellar, Maria Olívia Amado Ramos
Braga, Silvane
Castro, Bernardo Galvão
Neva, Franklin A.
dc.subject.por.fl_str_mv Cellular immunity in HTLV-1
Cytokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
topic Cellular immunity in HTLV-1
Cytokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
description p. 1-6
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2011-12-13T15:48:38Z
dc.date.available.fl_str_mv 2011-12-13T15:48:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/4834
dc.identifier.issn.none.fl_str_mv 1077-945
dc.identifier.number.pt_BR.fl_str_mv 27(1)
identifier_str_mv 1077-945
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url http://www.repositorio.ufba.br/ri/handle/ri/4834
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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collection Repositório Institucional da UFBA
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