Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57045 |
Resumo: | Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia. |
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Castro, Maria Del MarRode, JoelleMachado, Paulo R LLlanos-Cuentas, AlejandroHueb, MarciaCota, Gláucia FernandesRojas, Isis ValentinaOrobio, YeniferSarmiento, Oscar OviedoRojas, ErnestoQuintero, JulianaPimentel, Maria Inês FernandesSoto, JaimeSuprien, CarvelAlvarez, FiorelaRamos, Ana PilarArantes, Rayssa Basílio Dos SantosSilva, Rosiana Estéfane daArenas, Claudia MarcelaVélez, Ivan DaríoLyra, Marcelo RosandiskiSaravia, Nancy GoreArana, ByronAlexander, Neal2023-02-13T17:39:04Z2023-02-13T17:39:04Z2023CASTRO, Maria Del Mar et al. Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study. PLOS Neglected Tropical Diseases, v. 17, n. 1, p. 1-21, Jan 2023.1935-2735https://www.arca.fiocruz.br/handle/icict/5704510.1371/journal.pntd.0011029engPublic Library of ScienceCutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia.Drugs for Neglected Diseases initiative. Rio de Janeiro, RJ, Brazil.Universidade Federal da Bahia. Hospital Universitário Prof. Edgar Santos. Servico de Imunologia. Salvador, BA, Brazil.Unidad de Leishmaniasis y Malaria. Instituto de Medicina Tropical Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Perú / Hospital Cayetano Heredia. Lima, Perú.Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Centro Dermatológico Federico Lleras Acosta. Bogotá, Colombia.Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia.Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia.Centro Universitario de Medicina Tropical. Universidad Mayor de San Simón. Cochabamba, Bolivia.Programa de Estudio y Control de Enfermedades Tropicales. Facultad de Medicina. Universidad de Antioquia. Medellín, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundación Nacional de Dermatología. Santa Cruz de la Sierra, Bolivia.Universidade Federal da Bahia. Hospital Universitário Prof. Edgar Santos. Servico de Imunologia. Salvador, BA, Brazil.Unidad de Leishmaniasis y Malaria. Instituto de Medicina Tropical Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Perú / Hospital Cayetano Heredia. Lima, Perú.Unidad de Leishmaniasis y Malaria. Instituto de Medicina Tropical Alexander von Humboldt. Universidad Peruana Cayetano Heredia. Lima, Perú / Hospital Cayetano Heredia. Lima, Perú.Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Centro Dermatológico Federico Lleras Acosta. Bogotá, Colombia.Programa de Estudio y Control de Enfermedades Tropicales. Facultad de Medicina. Universidad de Antioquia. Medellín, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia.Background: Treatment guidance for children and older adult patients affected by cutaneous leishmaniasis (CL) is unclear due to limited representation of these groups in clinical trials. Methods: We conducted a collaborative retrospective study to describe the effectiveness and safety of antileishmanial treatments in children ≤ 10 and adults ≥ 60 years of age, treated between 2014 and 2018 in ten CL referral centers in Latin America. Results: 2,037 clinical records were assessed for eligibility. Of them, the main reason for non-inclusion was lack of data on treatment follow-up and therapeutic response (182/242, 75% of children and 179/468, 38% of adults). Data on 1,325 eligible CL patients (736 children and 589 older adults) were analyzed. In both age groups, disease presentation was mild, with a median number of lesions of one (IQR: 1-2) and median lesion diameter of less than 3 cm. Less than 50% of the patients had data for two or more follow-up visits post-treatment (being only 28% in pediatric patients). Systemic antimonials were the most common monotherapy regimen in both age groups (590/736, 80.2% of children and 308/589, 52.3% of older adults) with overall cure rates of 54.6% (95% CI: 50.5-58.6%) and 68.2% (95% CI: 62.6-73.4%), respectively. Other treatments used include miltefosine, amphotericin B, intralesional antimonials, and pentamidine. Adverse reactions related to the main treatment were experienced in 11.9% (86/722) of children versus 38.4% (206/537) of older adults. Most adverse reactions were of mild intensity. Conclusion: Our findings support the need for greater availability and use of alternatives to systemic antimonials, particularly local therapies, and development of strategies to improve patient follow-up across the region, with special attention to pediatric populations.Cutaneous Leishmaniasis TreatmentCutaneous LeishmaniasisPatientsClinical recordsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57045/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCutaneous leishmaniasis treatment and therapeutic outcomes in special populations_ A collaborative retrospective study - pntd.0011029.pdfCutaneous leishmaniasis treatment and therapeutic outcomes in special populations_ A collaborative retrospective study - pntd.0011029.pdfapplication/pdf9179553https://www.arca.fiocruz.br/bitstream/icict/57045/2/Cutaneous%20leishmaniasis%20treatment%20and%20therapeutic%20outcomes%20in%20special%20populations_%20A%20collaborative%20retrospective%20study%20-%20pntd.0011029.pdfe406585640eae16073754eefdfb570d8MD52icict/570452023-04-19 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| dc.title.en_US.fl_str_mv |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| title |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| spellingShingle |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study Castro, Maria Del Mar Cutaneous Leishmaniasis Treatment Cutaneous Leishmaniasis Patients Clinical records |
| title_short |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| title_full |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| title_fullStr |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| title_full_unstemmed |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| title_sort |
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study |
| author |
Castro, Maria Del Mar |
| author_facet |
Castro, Maria Del Mar Rode, Joelle Machado, Paulo R L Llanos-Cuentas, Alejandro Hueb, Marcia Cota, Gláucia Fernandes Rojas, Isis Valentina Orobio, Yenifer Sarmiento, Oscar Oviedo Rojas, Ernesto Quintero, Juliana Pimentel, Maria Inês Fernandes Soto, Jaime Suprien, Carvel Alvarez, Fiorela Ramos, Ana Pilar Arantes, Rayssa Basílio Dos Santos Silva, Rosiana Estéfane da Arenas, Claudia Marcela Vélez, Ivan Darío Lyra, Marcelo Rosandiski Saravia, Nancy Gore Arana, Byron Alexander, Neal |
| author_role |
author |
| author2 |
Rode, Joelle Machado, Paulo R L Llanos-Cuentas, Alejandro Hueb, Marcia Cota, Gláucia Fernandes Rojas, Isis Valentina Orobio, Yenifer Sarmiento, Oscar Oviedo Rojas, Ernesto Quintero, Juliana Pimentel, Maria Inês Fernandes Soto, Jaime Suprien, Carvel Alvarez, Fiorela Ramos, Ana Pilar Arantes, Rayssa Basílio Dos Santos Silva, Rosiana Estéfane da Arenas, Claudia Marcela Vélez, Ivan Darío Lyra, Marcelo Rosandiski Saravia, Nancy Gore Arana, Byron Alexander, Neal |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Maria Del Mar Rode, Joelle Machado, Paulo R L Llanos-Cuentas, Alejandro Hueb, Marcia Cota, Gláucia Fernandes Rojas, Isis Valentina Orobio, Yenifer Sarmiento, Oscar Oviedo Rojas, Ernesto Quintero, Juliana Pimentel, Maria Inês Fernandes Soto, Jaime Suprien, Carvel Alvarez, Fiorela Ramos, Ana Pilar Arantes, Rayssa Basílio Dos Santos Silva, Rosiana Estéfane da Arenas, Claudia Marcela Vélez, Ivan Darío Lyra, Marcelo Rosandiski Saravia, Nancy Gore Arana, Byron Alexander, Neal |
| dc.subject.en.none.fl_str_mv |
Cutaneous Leishmaniasis Treatment Cutaneous Leishmaniasis Patients Clinical records |
| topic |
Cutaneous Leishmaniasis Treatment Cutaneous Leishmaniasis Patients Clinical records |
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Centro Internacional de Entrenamiento e Investigaciones Médicas. Cali, Colombia / Universidad Icesi. Cali, Colombia. |
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2023 |
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2023-02-13T17:39:04Z |
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2023-02-13T17:39:04Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CASTRO, Maria Del Mar et al. Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study. PLOS Neglected Tropical Diseases, v. 17, n. 1, p. 1-21, Jan 2023. |
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https://www.arca.fiocruz.br/handle/icict/57045 |
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1935-2735 |
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10.1371/journal.pntd.0011029 |
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CASTRO, Maria Del Mar et al. Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study. PLOS Neglected Tropical Diseases, v. 17, n. 1, p. 1-21, Jan 2023. 1935-2735 10.1371/journal.pntd.0011029 |
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