Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes

Detalhes bibliográficos
Autor(a) principal: Pontes-de-Carvalho, Lain Carlos
Data de Publicação: 1987
Outros Autores: Vieira, Joseli Lannes, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6029
Resumo: CNPq
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spelling Pontes-de-Carvalho, Lain CarlosVieira, Joseli LannesSavino, Wilson2012-12-18T21:21:47Z2012-12-18T21:21:47Z1987PONTES-DE-CARVALHO, Lain Carlos; VIEIRA, Joseli Lannes; SAVINO, Wilson. Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes. Memórias do Instituto Oswaldo Cruz, v. 82, supl.2, p. 111-115, 1987.0074-0276https://www.arca.fiocruz.br/handle/icict/602910.1590/S0074-027619870006000171678-8060CNPqUNDP/World Bank WHO-TDRFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Despite the existence of erythrocyte-autoreactive B cells in normal animals, erythrocyte-autoantibodies could not be detected during polyclonal B-cell activation (PBA) both in patients with visceral leishmaniasis and in bacterial lipopolysacharide (LPS) - injected mice. The failure to detect these autoantibodies in mice with PBA di not seem to be due to suppressor-cell activity, since (1) transfer of spleen cells from LPS-treated mice to naive recipients did not affect the erythrocyte-autoantibody response elicited by subsequent injections of rat erythrocytes and (2) low doses of X-radiation did no lead to erythrocyte-autoantibody detection in LPS-treated mice. The possibility that the detection of erytrocyte-autoantibodies could be affected by autoantibodies with idiotopes mimicring erythrocyte epitopes, the synthesis of which would also be triggerred in PBA, is discussed. Indirect evidence for the existence in normal animal of an expanded lymphocyte population with DNP-binding. Ia-mimicring antigen receptors is presented.engInstituto Oswaldo Cruz, Ministério da SaúdeCélulas BAutoanticorposRepertórioAnimaisCamundongosB cellAutoantibodiesRepertoireAnimalsMiceRestriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPontes de Carvalho, L.C. et al. Restriction in the repertoire....pdfPontes de Carvalho, L.C. et al. 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dc.title.en.fl_str_mv Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
title Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
spellingShingle Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
Pontes-de-Carvalho, Lain Carlos
Células B
Autoanticorpos
Repertório
Animais
Camundongos
B cell
Autoantibodies
Repertoire
Animals
Mice
title_short Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
title_full Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
title_fullStr Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
title_full_unstemmed Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
title_sort Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes
author Pontes-de-Carvalho, Lain Carlos
author_facet Pontes-de-Carvalho, Lain Carlos
Vieira, Joseli Lannes
Savino, Wilson
author_role author
author2 Vieira, Joseli Lannes
Savino, Wilson
author2_role author
author
dc.contributor.author.fl_str_mv Pontes-de-Carvalho, Lain Carlos
Vieira, Joseli Lannes
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Células B
Autoanticorpos
Repertório
Animais
Camundongos
topic Células B
Autoanticorpos
Repertório
Animais
Camundongos
B cell
Autoantibodies
Repertoire
Animals
Mice
dc.subject.en.en.fl_str_mv B cell
Autoantibodies
Repertoire
Animals
Mice
description CNPq
publishDate 1987
dc.date.issued.fl_str_mv 1987
dc.date.accessioned.fl_str_mv 2012-12-18T21:21:47Z
dc.date.available.fl_str_mv 2012-12-18T21:21:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PONTES-DE-CARVALHO, Lain Carlos; VIEIRA, Joseli Lannes; SAVINO, Wilson. Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes. Memórias do Instituto Oswaldo Cruz, v. 82, supl.2, p. 111-115, 1987.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6029
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761987000600017
dc.identifier.eissn.pt_BR.fl_str_mv 1678-8060
identifier_str_mv PONTES-DE-CARVALHO, Lain Carlos; VIEIRA, Joseli Lannes; SAVINO, Wilson. Restriction in the repertoire of detectable autoantibodies in polyclonal B cell activations and the mimicry of autoantigens by idiotopes. Memórias do Instituto Oswaldo Cruz, v. 82, supl.2, p. 111-115, 1987.
0074-0276
10.1590/S0074-02761987000600017
1678-8060
url https://www.arca.fiocruz.br/handle/icict/6029
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
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