Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25602 |
Resumo: | 2018-12-31 |
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Moraes, Joyce LMoraes, Amanda BAran, VeronicaAlves, Marcelo RSchluckbier, LucieneDuarte, MarianaToscano, EdsonZamboni, MauroSternberg, Cinthyade Moraes, EmanuelaLapa E Silva, José RFerreira, Carlos Gil2018-04-03T19:10:10Z2018-04-03T19:10:10Z2017MORAES, Joyce L. et al. Functional analysis of polymorphisms in the COX‑2 gene and risk of lung cancer. Molecular and Clinical Oncology, v. 6, p. 494-205, 2017.2049-9450https://www.arca.fiocruz.br/handle/icict/2560210.3892/mco.2017.1167engFunctional analysis of polymorphisms in the COX-2 gene and risk of lung cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-12-31Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilFundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Cirurgia Torácica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Cirurgia Torácica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, BrasilUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Medicina Torácica. Rio de Janeiro, RJ, Brasil.National Clinical Cancer Research Network (RNPCC) SCTIE/MS. / Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, BrazilThe enzyme cyclooxygenase 2 (COX-2) is known to be involved in tumorigenesis and metastasis in certain types of cancer. Nevertheless, the prognostic value of COX-2 overexpression and its polymorphisms in patients with non-small cell lung cancer (NSCLC) have yet to be fully elucidated. The aim of the present study was to investigate the association between the three most commonly studied COX-2 gene polymorphisms (-1195 G/A, -765 G/C and 8473 T/C) with COX-2 expression and lung cancer risk in a Brazilian cohort. In the present hospital based, case-control retrospective study, 104 patients with NSCLC and 202 cancer free control subjects were genotyped for -1195 G/A, -765 G/C and 8473 T/C polymorphisms using allelic discrimination with a reverse transcription quantitative polymerase chain reaction method. COX-2 mRNA expression was analyzed in surgically resected tumors from 34 patients with NSCLC. The results revealed that COX-2 expression levels were higher in tumor tissue compared with normal lung tissue. However, this overexpression of COX-2 was not associated with the patient outcome, and furthermore, none of the analyzed polymorphisms were associated with the risk of developing lung cancer, COX-2 overexpression, or the overall survival of the patients with NSCLC. Taken together, the findings described in the present study do not support a major role for COX-2 polymorphisms and COX-2 overexpression in lung carcinogenesis within the Brazilian population.Cyclooxygenase 2TumorigenesisPolymorphismLung cancerCohortinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25602/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALve_Joyce_Moraes_etal_INI_Lapclin_2017.pdfve_Joyce_Moraes_etal_INI_Lapclin_2017.pdfapplication/pdf496690https://www.arca.fiocruz.br/bitstream/icict/25602/2/ve_Joyce_Moraes_etal_INI_Lapclin_2017.pdf3599628e27b8961cad930981d5fd519eMD52TEXTve_Joyce_Moraes_etal_INI_Lapclin_2017.pdf.txtve_Joyce_Moraes_etal_INI_Lapclin_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| title |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| spellingShingle |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer Moraes, Joyce L Cyclooxygenase 2 Tumorigenesis Polymorphism Lung cancer Cohort |
| title_short |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| title_full |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| title_fullStr |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| title_full_unstemmed |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| title_sort |
Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer |
| author |
Moraes, Joyce L |
| author_facet |
Moraes, Joyce L Moraes, Amanda B Aran, Veronica Alves, Marcelo R Schluckbier, Luciene Duarte, Mariana Toscano, Edson Zamboni, Mauro Sternberg, Cinthya de Moraes, Emanuela Lapa E Silva, José R Ferreira, Carlos Gil |
| author_role |
author |
| author2 |
Moraes, Amanda B Aran, Veronica Alves, Marcelo R Schluckbier, Luciene Duarte, Mariana Toscano, Edson Zamboni, Mauro Sternberg, Cinthya de Moraes, Emanuela Lapa E Silva, José R Ferreira, Carlos Gil |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moraes, Joyce L Moraes, Amanda B Aran, Veronica Alves, Marcelo R Schluckbier, Luciene Duarte, Mariana Toscano, Edson Zamboni, Mauro Sternberg, Cinthya de Moraes, Emanuela Lapa E Silva, José R Ferreira, Carlos Gil |
| dc.subject.en.pt_BR.fl_str_mv |
Cyclooxygenase 2 Tumorigenesis Polymorphism Lung cancer Cohort |
| topic |
Cyclooxygenase 2 Tumorigenesis Polymorphism Lung cancer Cohort |
| description |
2018-12-31 |
| publishDate |
2017 |
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2017 |
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2018-04-03T19:10:10Z |
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2018-04-03T19:10:10Z |
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info:eu-repo/semantics/publishedVersion |
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MORAES, Joyce L. et al. Functional analysis of polymorphisms in the COX‑2 gene and risk of lung cancer. Molecular and Clinical Oncology, v. 6, p. 494-205, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25602 |
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2049-9450 |
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10.3892/mco.2017.1167 |
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MORAES, Joyce L. et al. Functional analysis of polymorphisms in the COX‑2 gene and risk of lung cancer. Molecular and Clinical Oncology, v. 6, p. 494-205, 2017. 2049-9450 10.3892/mco.2017.1167 |
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