Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS

Detalhes bibliográficos
Autor(a) principal: Rotman, Vivian
Data de Publicação: 2016
Outros Autores: Carvalho, Alysson Roncally, Rodrigues, Rosana Souza, Medeiros, Denise Machado, Pinto, Eduardo Costa, Bozza, Fernando Augusto, Carvalho, Carlos Roberto Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s12871-016-0206-1
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32395
Resumo: Federal University of Rio de Janeiro. Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
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spelling Rotman, VivianCarvalho, Alysson RoncallyRodrigues, Rosana SouzaMedeiros, Denise MachadoPinto, Eduardo CostaBozza, Fernando AugustoCarvalho, Carlos Roberto Ribeiro2019-04-05T14:43:27Z2019-04-05T14:43:27Z2016ROTMAN, Vivian et al. Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS. BMC Anesthesiology, v. 16, n. 1, p. 1-10, July 2016.1471-2253https://www.arca.fiocruz.br/handle/icict/3239510.1186/s12871-016-0206-11471-2253engBMCEffects of the open lung concept following ARDSnet ventilation in patients with early ARDSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Rio de Janeiro. Internal Medicine Department. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas., Rio de Janeiro, RJ, Brasil.Copa D’Or Hospital. ICU. Rio de Janeiro, RJ, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of São Paulo. InCor-Hospital das Clinicas. Respiratory ICU. São Paulo, SP, Brazil.Background: Ventilation with low tidal volume (VT) is well recognized as a protective approach to patients with acute respiratory distress syndrome (ARDS), but the optimal level of positive end-expiratory pressure (PEEP) remains uncertain. This study aims to evaluate two protective ventilatory strategies sequentially applied in patients with early ARDS. Methods: In this prospective cohort study, fifteen patients were ventilated during 24 h with positive end-expiratory pressure (PEEP) adjusted according to the ARDSnet low-PEEP table (ARDSnet-24 h). During the next 24 h, nine patients with PaO2/FIO2 ratio below 350 mmHg were ventilated with PEEP titrated according to the Open Lung Concept protocol (ARDSnet + OLC). In the other six patients, regardless of their PaO2/FIO2 ratio, the ARDSnet remained for a further 24 h (ARDSnet-48 h). Ventilatory variables, arterial blood-gas and cytokine were obtained at baseline, 24 and 48 h. Additionally, whole-lung-computed tomography was acquired at 24 and 48 h. Results: A sustained improvement in PaO2/FIO2 ratio (P = 0.008) with a decrease in collapsed regions (P = 0.008) was observed in the ARDSnet + OLC group compared with the ARDSnet-24 h group. A reduction in IL-6 in plasma (P < 0.02) was observed throughout the protocol in the ARDSnet + OLC group. Compared with the ARDSnet-48 h group, the ARDSnet + OLC presented smaller amounts of collapsed areas (P = 0.018) without significant differences in hyperinflated regions and in driving and plateau pressures. Conclusions: In this set of patients with early ARDS, mechanical ventilation with an individually tailored PEEP sustained improved pulmonary function with better aeration, without significant increase in hyperinflated areas”.Adult respiratory distress syndromeMeasurement techniquesVentilation effectsTomographyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32395/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Rotman_Vivian_etal_INI_2016.pdfve_Rotman_Vivian_etal_INI_2016.pdfapplication/pdf2734747https://www.arca.fiocruz.br/bitstream/icict/32395/2/ve_Rotman_Vivian_etal_INI_2016.pdfe6c72fc4c886726c48214283680228cdMD52TEXTve_Rotman_Vivian_etal_INI_2016.pdf.txtve_Rotman_Vivian_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
title Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
spellingShingle Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
Rotman, Vivian
Adult respiratory distress syndrome
Measurement techniques
Ventilation effects
Tomography
title_short Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
title_full Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
title_fullStr Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
title_full_unstemmed Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
title_sort Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS
author Rotman, Vivian
author_facet Rotman, Vivian
Carvalho, Alysson Roncally
Rodrigues, Rosana Souza
Medeiros, Denise Machado
Pinto, Eduardo Costa
Bozza, Fernando Augusto
Carvalho, Carlos Roberto Ribeiro
author_role author
author2 Carvalho, Alysson Roncally
Rodrigues, Rosana Souza
Medeiros, Denise Machado
Pinto, Eduardo Costa
Bozza, Fernando Augusto
Carvalho, Carlos Roberto Ribeiro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rotman, Vivian
Carvalho, Alysson Roncally
Rodrigues, Rosana Souza
Medeiros, Denise Machado
Pinto, Eduardo Costa
Bozza, Fernando Augusto
Carvalho, Carlos Roberto Ribeiro
dc.subject.en.pt_BR.fl_str_mv Adult respiratory distress syndrome
Measurement techniques
Ventilation effects
Tomography
topic Adult respiratory distress syndrome
Measurement techniques
Ventilation effects
Tomography
description Federal University of Rio de Janeiro. Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-05T14:43:27Z
dc.date.available.fl_str_mv 2019-04-05T14:43:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROTMAN, Vivian et al. Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS. BMC Anesthesiology, v. 16, n. 1, p. 1-10, July 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32395
dc.identifier.issn.pt_BR.fl_str_mv 1471-2253
dc.identifier.doi.none.fl_str_mv 10.1186/s12871-016-0206-1
dc.identifier.eissn.none.fl_str_mv 1471-2253
identifier_str_mv ROTMAN, Vivian et al. Effects of the open lung concept following ARDSnet ventilation in patients with early ARDS. BMC Anesthesiology, v. 16, n. 1, p. 1-10, July 2016.
1471-2253
10.1186/s12871-016-0206-1
url https://www.arca.fiocruz.br/handle/icict/32395
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32395/1/license.txt
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