A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity

Bastos, Thais Sibioni Berti; Paula, André Guilherme Portela de; Luz, Rebeca Bosso dos Santos; Garnique, Anali M. B.; Belo, Marco A. A.; Eto, Silas Fernandes; Fernandes, Dayanne Carla; Ferraris, Fausto Klabund; Pontes, Leticia Gomes de; França, Tábata Takahashi; Barcellos, Leonardo José Gil; Veras, Flavio P.; Bermejo, Pamela; Guidelli, Giovanna; Maneira, Carla; Mello, Fellipe da Silveira Bezerra de; Teixeira, Gleidson; Pereira, Gonçalo Amarante Guimarães; Fernandes, Bianca H. Ventura; Sanches, Paulo R. S.; Braz, Helyson Lucas Bezerra; Jorge, Roberta Jeane Bezerra; Malafaia, Guilherme; Cilli, Eduardo M.; Olivier, Danilo da Silva; Amaral, Marcos Serrou do; Medeiros, Renata J.; Condino‑Neto, Antonio; Carvalho, Luciani R.; Machado‑Santelli, Glaucia M.; Charlie‑Silva, Ives; Galindo‑Villegas, Jorge; Braga, Tárcio Teodoro

A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity

Detalhes bibliográficos
Autor(a) principal:	Bastos, Thais Sibioni Berti
Data de Publicação:	2023
Outros Autores:	Paula, André Guilherme Portela de, Luz, Rebeca Bosso dos Santos, Garnique, Anali M. B., Belo, Marco A. A., Eto, Silas Fernandes, Fernandes, Dayanne Carla, Ferraris, Fausto Klabund, Pontes, Leticia Gomes de, França, Tábata Takahashi, Barcellos, Leonardo José Gil, Veras, Flavio P., Bermejo, Pamela, Guidelli, Giovanna, Maneira, Carla, Mello, Fellipe da Silveira Bezerra de, Teixeira, Gleidson, Pereira, Gonçalo Amarante Guimarães, Fernandes, Bianca H. Ventura, Sanches, Paulo R. S., Braz, Helyson Lucas Bezerra, Jorge, Roberta Jeane Bezerra, Malafaia, Guilherme, Cilli, Eduardo M., Olivier, Danilo da Silva, Amaral, Marcos Serrou do, Medeiros, Renata J., Condino‑Neto, Antonio, Carvalho, Luciani R., Machado‑Santelli, Glaucia M., Charlie‑Silva, Ives, Galindo‑Villegas, Jorge, Braga, Tárcio Teodoro
Tipo de documento:	Artigo
Idioma:	por
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/59232
Resumo:	Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Bastos, Thais Sibioni BertiPaula, André Guilherme Portela deLuz, Rebeca Bosso dos SantosGarnique, Anali M. B.Belo, Marco A. A.Eto, Silas FernandesFernandes, Dayanne CarlaFerraris, Fausto KlabundPontes, Leticia Gomes deFrança, Tábata TakahashiBarcellos, Leonardo José GilVeras, Flavio P.Bermejo, PamelaGuidelli, GiovannaManeira, CarlaMello, Fellipe da Silveira Bezerra deTeixeira, GleidsonPereira, Gonçalo Amarante GuimarãesFernandes, Bianca H. VenturaSanches, Paulo R. S.Braz, Helyson Lucas BezerraJorge, Roberta Jeane BezerraMalafaia, GuilhermeCilli, Eduardo M.Olivier, Danilo da SilvaAmaral, Marcos Serrou doMedeiros, Renata J.Condino‑Neto, AntonioCarvalho, Luciani R.Machado‑Santelli, Glaucia M.Charlie‑Silva, IvesGalindo‑Villegas, JorgeBraga, Tárcio Teodoro2023-06-28T19:48:37Z2023-06-28T19:48:37Z2023BASTOS, Thais Sibioni Berti et al. A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity. Scientific Reports, v. 13, n. 8060, p. 1-15, 2023.2045-2322https://www.arca.fiocruz.br/handle/icict/59232porNatureImunidadeZebrafishModels, AnimalPeptidesImmunityPez CebraModelos AnimalesPéptidosInmunidadDanio zébréModèles animauxPeptidesImmunitéSARS-CoV-2COVID-19Peixe-ZebraModelos AnimaisPeptídeosResposta ImuneA novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Biologia Celular. São Paulo, SP, Brasil.Universidade Brasil. Descalvado. São Paulo, SP, Brasil.Instituto Butantan. Centro de Excelência para Descobertas de Alvos Moleculares. Laboratório Especial. São Paulo, SP, Brasil. / Instituto Butantan. Centro de Inovação e Desenvolvimento. Laboratório de Desenvolvimento e Inovação. São Paulo, SP, Brasil.Veterinarian. São Paulo, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle da Qualidade em Saúde. Departamento de Farmacologia e Toxicologia, Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunologia Humana. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunologia Humana. São Paulo, SP, Brasil.Universidade de Passo Fundo. Programa de Pós-Graduação em Bioexperimentação. Laboratório de Fisiologia de Peixes. Passo Fundo, RS, Brasil. / Universidade Federal de Santa Maria. Programa de Pós-Graduação em Farmacologia . Santa Maria, RS, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Centro de Pesquisa em Doenças Inflamatórias. Ribeirão Preto, SP, Brasil. / Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Laboratório de Genômica e bioEnergia. Campinas, SP, Brasil.Faculdade de Medicina da Universidade de São Paulo. Diretoria Técnica de Apoio ao Ensino e Pesquisa. Laboratório de Controle Genético e Sanitário. São Paulo, SP, Brasil.Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil.Instituto Federal Goiano. Campus Urutaí. Laboratório de Pesquisa Biológica. Urutaí, GO, Brasil.Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil.Universidade Federal de Tocantins. Centro Integrado de Ciências. Araguaína, TO, Brasil.Universidade Federal de Mato Grosso do Sul. Instituto de Física. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle da Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Laboratório de Fisiologia / Zebrafish Facility. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunologia Humana. São Paulo, SP, Brasil.Faculdade de Medicina da Universidade de São Paulo. Diretoria Técnica de Apoio ao Ensino e Pesquisa. Laboratório de Controle Genético e Sanitário. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Biologia Celular e do Desenvolvimento. Laboratório de Biologia Celular e Molecular. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Farmacologia. São Paulo, SP, Brasil.Department of Genomics. Faculty of Biosciences and Aquaculture. Nord University. Bodø, Norway.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers of infected persons, an overburdened health care system, and the lack of an effective and definitive treatment. Understanding the pathophysiology of the disease is crucial for the development of new technologies and therapies for the best clinical management of patients. Since the manipulation of the whole virus requires a structure with an adequate level of biosafety, the development of alternative technologies, such as the synthesis of peptides from viral proteins, is a possible solution to circumvent this problem. In addition, the use and validation of animal models is of extreme importance to screen new drugs and to compress the organism’s response to the disease. Peptides derived from recombinant S protein from SARS-CoV-2 were synthesized and validated by in silico, in vitro and in vivo methodologies. Macrophages and neutrophils were challenged with the peptides and the production of inflammatory mediators and activation profile were evaluated. These peptides were also inoculated into the swim bladder of transgenic zebrafish larvae at 6 days post fertilization (dpf) to mimic the inflammatory process triggered by the virus, which was evaluated by confocal microscopy. In addition, toxicity and oxidative stress assays were also developed. In silico and molecular dynamics assays revealed that the peptides bind to the ACE2 receptor stably and interact with receptors and adhesion molecules, such as MHC and TCR, from humans and zebrafish. Macrophages stimulated with one of the peptides showed increased production of NO, TNF-α and CXCL2. Inoculation of the peptides in zebrafish larvae triggered an inflammatory process marked by macrophage recruitment and increased mortality, as well as histopathological changes, similarly to what is observed in individuals with COVID-19. The use of peptides is a valuable alternative for the study of host immune response in the context of COVID-19. The use of zebrafish as an animal model also proved to be appropriate and effective in evaluating the inflammatory process, comparable to humans.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59232/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALs41598-023-29588-8OK.pdfs41598-023-29588-8OK.pdfapplication/pdf1953084https://www.arca.fiocruz.br/bitstream/icict/59232/2/s41598-023-29588-8OK.pdf0542a0ae6c9100f6d1a45702c87e85f7MD52s41598-023-39134-Errata.pdfs41598-023-39134-Errata.pdfErrata_Posterior_Publicacaoapplication/pdf815069https://www.arca.fiocruz.br/bitstream/icict/59232/3/s41598-023-39134-Errata.pdfa8717c7a361fafca319fbb13f5039a4cMD53icict/592322023-08-07 11:42:53.202oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
title	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
spellingShingle	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity Bastos, Thais Sibioni Berti Imunidade Zebrafish Models, Animal Peptides Immunity Pez Cebra Modelos Animales Péptidos Inmunidad Danio zébré Modèles animaux Peptides Immunité SARS-CoV-2 COVID-19 Peixe-Zebra Modelos Animais Peptídeos Resposta Imune
title_short	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
title_full	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
title_fullStr	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
title_full_unstemmed	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
title_sort	A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity
author	Bastos, Thais Sibioni Berti
author_facet	Bastos, Thais Sibioni Berti Paula, André Guilherme Portela de Luz, Rebeca Bosso dos Santos Garnique, Anali M. B. Belo, Marco A. A. Eto, Silas Fernandes Fernandes, Dayanne Carla Ferraris, Fausto Klabund Pontes, Leticia Gomes de França, Tábata Takahashi Barcellos, Leonardo José Gil Veras, Flavio P. Bermejo, Pamela Guidelli, Giovanna Maneira, Carla Mello, Fellipe da Silveira Bezerra de Teixeira, Gleidson Pereira, Gonçalo Amarante Guimarães Fernandes, Bianca H. Ventura Sanches, Paulo R. S. Braz, Helyson Lucas Bezerra Jorge, Roberta Jeane Bezerra Malafaia, Guilherme Cilli, Eduardo M. Olivier, Danilo da Silva Amaral, Marcos Serrou do Medeiros, Renata J. Condino‑Neto, Antonio Carvalho, Luciani R. Machado‑Santelli, Glaucia M. Charlie‑Silva, Ives Galindo‑Villegas, Jorge Braga, Tárcio Teodoro
author_role	author
author2	Paula, André Guilherme Portela de Luz, Rebeca Bosso dos Santos Garnique, Anali M. B. Belo, Marco A. A. Eto, Silas Fernandes Fernandes, Dayanne Carla Ferraris, Fausto Klabund Pontes, Leticia Gomes de França, Tábata Takahashi Barcellos, Leonardo José Gil Veras, Flavio P. Bermejo, Pamela Guidelli, Giovanna Maneira, Carla Mello, Fellipe da Silveira Bezerra de Teixeira, Gleidson Pereira, Gonçalo Amarante Guimarães Fernandes, Bianca H. Ventura Sanches, Paulo R. S. Braz, Helyson Lucas Bezerra Jorge, Roberta Jeane Bezerra Malafaia, Guilherme Cilli, Eduardo M. Olivier, Danilo da Silva Amaral, Marcos Serrou do Medeiros, Renata J. Condino‑Neto, Antonio Carvalho, Luciani R. Machado‑Santelli, Glaucia M. Charlie‑Silva, Ives Galindo‑Villegas, Jorge Braga, Tárcio Teodoro
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Bastos, Thais Sibioni Berti Paula, André Guilherme Portela de Luz, Rebeca Bosso dos Santos Garnique, Anali M. B. Belo, Marco A. A. Eto, Silas Fernandes Fernandes, Dayanne Carla Ferraris, Fausto Klabund Pontes, Leticia Gomes de França, Tábata Takahashi Barcellos, Leonardo José Gil Veras, Flavio P. Bermejo, Pamela Guidelli, Giovanna Maneira, Carla Mello, Fellipe da Silveira Bezerra de Teixeira, Gleidson Pereira, Gonçalo Amarante Guimarães Fernandes, Bianca H. Ventura Sanches, Paulo R. S. Braz, Helyson Lucas Bezerra Jorge, Roberta Jeane Bezerra Malafaia, Guilherme Cilli, Eduardo M. Olivier, Danilo da Silva Amaral, Marcos Serrou do Medeiros, Renata J. Condino‑Neto, Antonio Carvalho, Luciani R. Machado‑Santelli, Glaucia M. Charlie‑Silva, Ives Galindo‑Villegas, Jorge Braga, Tárcio Teodoro
dc.subject.other.en_US.fl_str_mv	Imunidade
topic	Imunidade Zebrafish Models, Animal Peptides Immunity Pez Cebra Modelos Animales Péptidos Inmunidad Danio zébré Modèles animaux Peptides Immunité SARS-CoV-2 COVID-19 Peixe-Zebra Modelos Animais Peptídeos Resposta Imune
dc.subject.en.en_US.fl_str_mv	Zebrafish Models, Animal Peptides Immunity
dc.subject.es.en_US.fl_str_mv	Pez Cebra Modelos Animales Péptidos Inmunidad
dc.subject.fr.en_US.fl_str_mv	Danio zébré Modèles animaux Peptides Immunité
dc.subject.decs.en_US.fl_str_mv	SARS-CoV-2 COVID-19 Peixe-Zebra Modelos Animais Peptídeos Resposta Imune
description	Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.
publishDate	2023
dc.date.accessioned.fl_str_mv	2023-06-28T19:48:37Z
dc.date.available.fl_str_mv	2023-06-28T19:48:37Z
dc.date.issued.fl_str_mv	2023
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BASTOS, Thais Sibioni Berti et al. A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity. Scientific Reports, v. 13, n. 8060, p. 1-15, 2023.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/59232
dc.identifier.issn.en_US.fl_str_mv	2045-2322
identifier_str_mv	BASTOS, Thais Sibioni Berti et al. A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity. Scientific Reports, v. 13, n. 8060, p. 1-15, 2023. 2045-2322
url	https://www.arca.fiocruz.br/handle/icict/59232
dc.language.iso.fl_str_mv	por
language	por
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Nature
publisher.none.fl_str_mv	Nature
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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A novel insight on SARS‑CoV‑2 S‑derived fragments in the control of the host immunity

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