Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56852 |
Resumo: | Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil. |
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Tozzi, Ollavo NogueiraJiacomini, Isabella GizziBastos, Thaís Sibioni BertiNicolazzi, Laura Helena Cherem NettoLuz, Rebeca Bosso dos SantosParedes, Laís CavalieriGonçalves, Luis EduardoLima, Murilo Henrique SaturninoVerri Junior, Waldiceu A.Camara, Niels Olsen SaraivaAssis, Helena Cristina Silva deCastilho, Marisa Fernandes deAlvarenga, Larissa MagalhaesBraga, Tárcio Teodoro2023-02-03T14:29:34Z2023-02-03T14:29:34Z2022TOZZI, Ollavo Nogueira et al. Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish. Toxicology Reports, n. 9, p. 1410–1418, 2022.2214-7500https://www.arca.fiocruz.br/handle/icict/56852porElsevierMaresin 2Resolvin D5ZebrafishBrown Recluse SpiderSpider VenomsPez CebraAraña Reclusa PardaVenenos de ArañaDanio zébréAraignée recluse bruneVenins d'araignéePeixe-ZebraAranha Marrom ReclusaVenenos de AranhaEvaluation of the effects of Loxosceles intermedia’s venom in zebrafishinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade de São Paulo. Departamento de Imunologia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Patologia. Londrina, PR, Brasil.Universidade de São Paulo. Departamento de Imunologia. São Paulo, SP, Brasil.Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Fisiologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.The zebrafish is an animal model of increasing use in many biomedical fields of study, including toxicology, inflammation, and tissue regeneration. In this paper, we have investigated the inflammatory effects of Loxosceles intermedia’s venom (LIV) on zebrafish, as well as the effects of Maresin 2 (Mar2) and Resolvin D5 (RvD5), two specialized pro-resolving mediators (SPMs), in the context of tissue regeneration after fin fold amputation. Furthermore, increasing concentrations of LIV (250–2000 ng) were assayed for their haemolytic effects in vitro, and, afterwards, the same concentrations were evaluated in vivo, when injected intraperitoneally. LIV caused haemolysis in human red blood cells (RBCs), but not in zebrafish RBCs. The survival curve was also not altered by LIV injection, regardless of venom dosage. Histological analysis of renal and hepatic tissues, as well as the whole animal, revealed no pathological differences between LIV-injected and PBS-injected groups. Fin fold regeneration was not altered between LIV-injected and control groups, nor in the presence of MaR2 and RvD5. Results of swimming behavioral analysis also did not differ between groups. Moreover, in silico data indicated differences between human and zebrafish cell membrane lipid constitutions, such as in phospholipases D preferred substrates, that could lead to the protection of zebrafish against LIV. Although our data implies that zebrafish cannot be used as a toxicological model for LIV studies, the absence of observed toxicological effects paves the way for the comprehension of the venom’s mechanism of action in mammals and the fundamental evolutionary processes involved.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56852/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALToxicology_Tozzi_Evaluation.pdfToxicology_Tozzi_Evaluation.pdfapplication/pdf11291278https://www.arca.fiocruz.br/bitstream/icict/56852/2/Toxicology_Tozzi_Evaluation.pdfadfa8ab570d11b636d3d47d9e88795e4MD52icict/568522023-02-03 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dc.title.en_US.fl_str_mv |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
title |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
spellingShingle |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish Tozzi, Ollavo Nogueira Maresin 2 Resolvin D5 Zebrafish Brown Recluse Spider Spider Venoms Pez Cebra Araña Reclusa Parda Venenos de Araña Danio zébré Araignée recluse brune Venins d'araignée Peixe-Zebra Aranha Marrom Reclusa Venenos de Aranha |
title_short |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
title_full |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
title_fullStr |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
title_full_unstemmed |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
title_sort |
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish |
author |
Tozzi, Ollavo Nogueira |
author_facet |
Tozzi, Ollavo Nogueira Jiacomini, Isabella Gizzi Bastos, Thaís Sibioni Berti Nicolazzi, Laura Helena Cherem Netto Luz, Rebeca Bosso dos Santos Paredes, Laís Cavalieri Gonçalves, Luis Eduardo Lima, Murilo Henrique Saturnino Verri Junior, Waldiceu A. Camara, Niels Olsen Saraiva Assis, Helena Cristina Silva de Castilho, Marisa Fernandes de Alvarenga, Larissa Magalhaes Braga, Tárcio Teodoro |
author_role |
author |
author2 |
Jiacomini, Isabella Gizzi Bastos, Thaís Sibioni Berti Nicolazzi, Laura Helena Cherem Netto Luz, Rebeca Bosso dos Santos Paredes, Laís Cavalieri Gonçalves, Luis Eduardo Lima, Murilo Henrique Saturnino Verri Junior, Waldiceu A. Camara, Niels Olsen Saraiva Assis, Helena Cristina Silva de Castilho, Marisa Fernandes de Alvarenga, Larissa Magalhaes Braga, Tárcio Teodoro |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tozzi, Ollavo Nogueira Jiacomini, Isabella Gizzi Bastos, Thaís Sibioni Berti Nicolazzi, Laura Helena Cherem Netto Luz, Rebeca Bosso dos Santos Paredes, Laís Cavalieri Gonçalves, Luis Eduardo Lima, Murilo Henrique Saturnino Verri Junior, Waldiceu A. Camara, Niels Olsen Saraiva Assis, Helena Cristina Silva de Castilho, Marisa Fernandes de Alvarenga, Larissa Magalhaes Braga, Tárcio Teodoro |
dc.subject.other.en_US.fl_str_mv |
Maresin 2 Resolvin D5 |
topic |
Maresin 2 Resolvin D5 Zebrafish Brown Recluse Spider Spider Venoms Pez Cebra Araña Reclusa Parda Venenos de Araña Danio zébré Araignée recluse brune Venins d'araignée Peixe-Zebra Aranha Marrom Reclusa Venenos de Aranha |
dc.subject.en.en_US.fl_str_mv |
Zebrafish Brown Recluse Spider Spider Venoms |
dc.subject.es.en_US.fl_str_mv |
Pez Cebra Araña Reclusa Parda Venenos de Araña |
dc.subject.fr.en_US.fl_str_mv |
Danio zébré Araignée recluse brune Venins d'araignée |
dc.subject.decs.en_US.fl_str_mv |
Peixe-Zebra Aranha Marrom Reclusa Venenos de Aranha |
description |
Universidade Federal do Paraná. Departamento de Patologia Básica. Curitiba, PR, Brasil. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-02-03T14:29:34Z |
dc.date.available.fl_str_mv |
2023-02-03T14:29:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TOZZI, Ollavo Nogueira et al. Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish. Toxicology Reports, n. 9, p. 1410–1418, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/56852 |
dc.identifier.issn.en_US.fl_str_mv |
2214-7500 |
identifier_str_mv |
TOZZI, Ollavo Nogueira et al. Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish. Toxicology Reports, n. 9, p. 1410–1418, 2022. 2214-7500 |
url |
https://www.arca.fiocruz.br/handle/icict/56852 |
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Elsevier |
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Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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https://www.arca.fiocruz.br/bitstream/icict/56852/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/56852/2/Toxicology_Tozzi_Evaluation.pdf |
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