Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil

Detalhes bibliográficos
Autor(a) principal: Pacheco, Sidelcina Rugieri
Data de Publicação: 2023
Outros Autores: Schinoni, Maria Isabel, Stocker, Andreas, Paraná, Raymundo, Reis, Mitermayer Galvão dos, Silva, Luciano Kalabric
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59055
Resumo: Fundação Maria Emília de Carvalho Freire.
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spelling Pacheco, Sidelcina RugieriSchinoni, Maria IsabelStocker, AndreasParaná, RaymundoReis, Mitermayer Galvão dosSilva, Luciano Kalabric2023-06-16T14:29:58Z2023-06-16T14:29:58Z2023PACHECO, Sidelcina Rugieri et al. Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil. Archives of Medical Research, v. 11, n. 3, p. 1-9, 2023.0188-4409https://www.arca.fiocruz.br/handle/icict/5905510.18103/mra.v11i3.3473Fundação Maria Emília de Carvalho Freire.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Mutations of genotypic resistance to nucleotide analogues Entecavirand Tenofovirhave been described in patients undergoing treatment and virgins for hepatitis B virus. The present study demonstrated in a sample of 263 patients with chronic HBV from the North and Northeast of Brazil, a mutation rate of resistance to nucleotide analogues of 3.8% (10). Of the 10 patients who had genotypic resistance mutations, only 1 had no genotypic resistance mutation for the first line treatment for hepatitis B, entecavir and tenofovir.Due to the emergence of vaccine escape mutations and resistance mutations to antiviral treatment, and the severity of liver disease caused by HBV, screening for genetic mutations is important due to the impact on therapeutic management.engElsevierHepatite BMutações genotípicasEntecavirTenofovirHepatitis BGenotypic mutationsEntecavirTenofovirHepatite BMutaçãoGenéticaTenofovirPrevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPacheco, S. R. Prevalence of Genotypic.pdfPacheco, S. R. Prevalence of Genotypic.pdfapplication/pdf235679https://www.arca.fiocruz.br/bitstream/icict/59055/2/Pacheco%2c%20S.%20R.%20Prevalence%20%20of%20%20Genotypic.pdf8f5e4ae909adec0ecde6930b2e967e72MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59055/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/590552023-06-16 11:29:59.201oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-16T14:29:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
title Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
spellingShingle Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
Pacheco, Sidelcina Rugieri
Hepatite B
Mutações genotípicas
Entecavir
Tenofovir
Hepatitis B
Genotypic mutations
Entecavir
Tenofovir
Hepatite B
Mutação
Genética
Tenofovir
title_short Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
title_full Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
title_fullStr Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
title_full_unstemmed Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
title_sort Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil
author Pacheco, Sidelcina Rugieri
author_facet Pacheco, Sidelcina Rugieri
Schinoni, Maria Isabel
Stocker, Andreas
Paraná, Raymundo
Reis, Mitermayer Galvão dos
Silva, Luciano Kalabric
author_role author
author2 Schinoni, Maria Isabel
Stocker, Andreas
Paraná, Raymundo
Reis, Mitermayer Galvão dos
Silva, Luciano Kalabric
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pacheco, Sidelcina Rugieri
Schinoni, Maria Isabel
Stocker, Andreas
Paraná, Raymundo
Reis, Mitermayer Galvão dos
Silva, Luciano Kalabric
dc.subject.other.en_US.fl_str_mv Hepatite B
Mutações genotípicas
Entecavir
Tenofovir
topic Hepatite B
Mutações genotípicas
Entecavir
Tenofovir
Hepatitis B
Genotypic mutations
Entecavir
Tenofovir
Hepatite B
Mutação
Genética
Tenofovir
dc.subject.en.en_US.fl_str_mv Hepatitis B
Genotypic mutations
Entecavir
Tenofovir
dc.subject.decs.en_US.fl_str_mv Hepatite B
Mutação
Genética
Tenofovir
description Fundação Maria Emília de Carvalho Freire.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-16T14:29:58Z
dc.date.available.fl_str_mv 2023-06-16T14:29:58Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PACHECO, Sidelcina Rugieri et al. Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil. Archives of Medical Research, v. 11, n. 3, p. 1-9, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59055
dc.identifier.issn.en_US.fl_str_mv 0188-4409
dc.identifier.doi.none.fl_str_mv 10.18103/mra.v11i3.3473
identifier_str_mv PACHECO, Sidelcina Rugieri et al. Prevalence of genotypic resistance mutations in patients with chronic hepatitis B (HBV) treated with entecavir and tenofovir in two reference centers in the North and Northeast of Brazil. Archives of Medical Research, v. 11, n. 3, p. 1-9, 2023.
0188-4409
10.18103/mra.v11i3.3473
url https://www.arca.fiocruz.br/handle/icict/59055
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59055/2/Pacheco%2c%20S.%20R.%20Prevalence%20%20of%20%20Genotypic.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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