HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.imbio.2017.08.001 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25560 |
Resumo: | 2018-08-31 |
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Barros, Luciana Rodrigues CarvalhoLinhares-Lacerda, LeandraMoreira-Ramos, KlaysaRibeiro-Alves, MarceloMotta, Maria Cristina MachadoBou-Habib, Dumith ChequerSavino, Wilson2018-04-02T17:53:22Z2018-04-02T17:53:22Z2017BARROS, Luciana Rodrigues Carvalho et. al. HTLV-1-infected thymic epithelial cells convey the virus to CD4+ T lymphocytes. Immunobiology, v. 222, p. 1053-1063, 2017.0171-2985https://www.arca.fiocruz.br/handle/icict/2556010.1016/j.imbio.2017.08.001engElsivierHTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-08-31Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), BrazilUniversidade Estadual de Ciências da Saúde de Alagoas. Maceio, Alagoas. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), BrazilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), BrazilThe human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells. Herein, we show that TEC express the receptors for HTLV-1 and can be infected by this virus through cell-cell contact and by cell-free virus suspensions. The expression of anti-apoptosis, chemokine and adhesion molecules genes are altered in HTLV-1-infected TEC, although gene expression of antigen presentation molecules remained unchanged. Furthermore, HTLV-1-infected TEC transmitted the virus to a CD4+T cell line and to CD4+T cells from healthy donors, during in vitro cellular co-cultures. Altogether, our data point to the possibility that the human thymic epithelial cells play a role in the establishment and progression of HTLV-1 infection, functioning as a reservoir and transmitting the virus to maturing CD4+T lymphocytes, which in turn will cause disease in the periphery.HTLV-I infectionCD4+ T lymphocytesThymic epithelial cellsCell migrationNeuropilin-1ChemokinesHTLV-I infectionCD4+ T lymphocytesCell migrationNeuropilin-1Chemokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| title |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| spellingShingle |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes Barros, Luciana Rodrigues Carvalho HTLV-I infection CD4+ T lymphocytes Thymic epithelial cells Cell migration Neuropilin-1 Chemokines HTLV-I infection CD4+ T lymphocytes Cell migration Neuropilin-1 Chemokines |
| title_short |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| title_full |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| title_fullStr |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| title_full_unstemmed |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| title_sort |
HTLV-1-infected thymic epithelial cells convey the virus to CD4+T lymphocytes |
| author |
Barros, Luciana Rodrigues Carvalho |
| author_facet |
Barros, Luciana Rodrigues Carvalho Linhares-Lacerda, Leandra Moreira-Ramos, Klaysa Ribeiro-Alves, Marcelo Motta, Maria Cristina Machado Bou-Habib, Dumith Chequer Savino, Wilson |
| author_role |
author |
| author2 |
Linhares-Lacerda, Leandra Moreira-Ramos, Klaysa Ribeiro-Alves, Marcelo Motta, Maria Cristina Machado Bou-Habib, Dumith Chequer Savino, Wilson |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros, Luciana Rodrigues Carvalho Linhares-Lacerda, Leandra Moreira-Ramos, Klaysa Ribeiro-Alves, Marcelo Motta, Maria Cristina Machado Bou-Habib, Dumith Chequer Savino, Wilson |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-I infection CD4+ T lymphocytes Thymic epithelial cells Cell migration Neuropilin-1 Chemokines |
| topic |
HTLV-I infection CD4+ T lymphocytes Thymic epithelial cells Cell migration Neuropilin-1 Chemokines HTLV-I infection CD4+ T lymphocytes Cell migration Neuropilin-1 Chemokines |
| dc.subject.decs.pt_BR.fl_str_mv |
HTLV-I infection CD4+ T lymphocytes Cell migration Neuropilin-1 Chemokines |
| description |
2018-08-31 |
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2017 |
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2017 |
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2018-04-02T17:53:22Z |
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2018-04-02T17:53:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARROS, Luciana Rodrigues Carvalho et. al. HTLV-1-infected thymic epithelial cells convey the virus to CD4+ T lymphocytes. Immunobiology, v. 222, p. 1053-1063, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25560 |
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0171-2985 |
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10.1016/j.imbio.2017.08.001 |
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BARROS, Luciana Rodrigues Carvalho et. al. HTLV-1-infected thymic epithelial cells convey the virus to CD4+ T lymphocytes. Immunobiology, v. 222, p. 1053-1063, 2017. 0171-2985 10.1016/j.imbio.2017.08.001 |
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