Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?

Detalhes bibliográficos
Autor(a) principal: Ramos, Klaysa Moreira
Data de Publicação: 2011
Outros Autores: Castro, Flávia Madeira Monteiro de, Lacerda, Leandra Linhares, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12371
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional do Câncer. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual de Ciências da Saúde de Alagoas. Maceió, AL, Brasil.
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spelling Ramos, Klaysa MoreiraCastro, Flávia Madeira Monteiro deLacerda, Leandra LinharesSavino, Wilson2015-12-10T11:23:49Z2015-12-10T11:23:49Z2011RAMOS, Klaysa Moreira; et al. Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?. Mem Inst Oswaldo Cruz, v.106, n.6, p.759-762, Sept. 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/12371engFundação Oswaldo CruzCan thymic epithelial cells be infected by human T-lymphotropic virus type 1?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional do Câncer. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual de Ciências da Saúde de Alagoas. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil.The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium.Thymic epithelial cellsHTLV-1 infectionAdult T cell leukaemia/lymphomaCell adhesionAdesão CelularCélulas EpiteliaisLeucemiaLinformainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12371/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALwilson_savino_etal_ioc_2013.pdfwilson_savino_etal_ioc_2013.pdfapplication/pdf705260https://www.arca.fiocruz.br/bitstream/icict/12371/2/wilson_savino_etal_ioc_2013.pdf7074a94a6db08a4645bc680aec1de5acMD52TEXTwilson_savino_etal_ioc_2013.pdf.txtwilson_savino_etal_ioc_2013.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
title Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
spellingShingle Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
Ramos, Klaysa Moreira
Thymic epithelial cells
HTLV-1 infection
Adult T cell leukaemia/lymphoma
Cell adhesion
Adesão Celular
Células Epiteliais
Leucemia
Linforma
title_short Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
title_full Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
title_fullStr Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
title_full_unstemmed Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
title_sort Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
author Ramos, Klaysa Moreira
author_facet Ramos, Klaysa Moreira
Castro, Flávia Madeira Monteiro de
Lacerda, Leandra Linhares
Savino, Wilson
author_role author
author2 Castro, Flávia Madeira Monteiro de
Lacerda, Leandra Linhares
Savino, Wilson
author2_role author
author
author
dc.contributor.author.fl_str_mv Ramos, Klaysa Moreira
Castro, Flávia Madeira Monteiro de
Lacerda, Leandra Linhares
Savino, Wilson
dc.subject.en.pt_BR.fl_str_mv Thymic epithelial cells
HTLV-1 infection
Adult T cell leukaemia/lymphoma
Cell adhesion
topic Thymic epithelial cells
HTLV-1 infection
Adult T cell leukaemia/lymphoma
Cell adhesion
Adesão Celular
Células Epiteliais
Leucemia
Linforma
dc.subject.decs.pt_BR.fl_str_mv Adesão Celular
Células Epiteliais
Leucemia
Linforma
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional do Câncer. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual de Ciências da Saúde de Alagoas. Maceió, AL, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2015-12-10T11:23:49Z
dc.date.available.fl_str_mv 2015-12-10T11:23:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMOS, Klaysa Moreira; et al. Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?. Mem Inst Oswaldo Cruz, v.106, n.6, p.759-762, Sept. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12371
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv RAMOS, Klaysa Moreira; et al. Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?. Mem Inst Oswaldo Cruz, v.106, n.6, p.759-762, Sept. 2011.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/12371
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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