The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis

Detalhes bibliográficos
Autor(a) principal: Freedberg, Kenneth A.
Data de Publicação: 2015
Outros Autores: Possas, Cristina, Deeks, Steven, Ross, Anna Laura, Rosettie, Katherine L., Mascio, Michele Di, Collins, Chris, Walensky, Rochelle P., Yazdanpanah, Yazdan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32306
Resumo: For the International AIDS Society Working Group on Cost-Effectiveness: Towards an HIV Cure Initiative.
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spelling Freedberg, Kenneth A.Possas, CristinaDeeks, StevenRoss, Anna LauraRosettie, Katherine L.Mascio, Michele DiCollins, ChrisWalensky, Rochelle P.Yazdanpanah, Yazdan2019-03-29T19:37:13Z2019-03-29T19:37:13Z2015FREEDBERG, Kenneth A. et al. The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis. Journal Of Virus Eradication, London, v. 4, n. 1, p. 245-249, 2015.2055-6640https://www.arca.fiocruz.br/handle/icict/32306For the International AIDS Society Working Group on Cost-Effectiveness: Towards an HIV Cure Initiative.Divisions of General Internal Medicine and Infectious Disease, Massachusetts General Hospital, Boston, USA / Harvard TH Chan School of Public Health. Department of Health Policy and Management. Boston, USA.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil.San Francisco General Hospital. University of California San Francisco. Department of Medicine.San Francisco, CA, USA / National Institutes of Health. Department of Health and Human Services. Bethesda, MD, USA.International AIDS Society, Geneva, Switzerland / ANRS. International and Scientific Relations Office. Paris, France.National Institute of Allergy and Infectious Diseases. Division of Clinical Research. National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.National Institute of Allergy and Infectious Diseases. Division of Clinical Research. National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.Joint United Nations Programme on HIV/AIDS (UNAIDS). Community Mobilization Division. Geneva, Switzerland.Joint United Nations Programme on HIV/AIDS (UNAIDS). Community Mobilization Division. Geneva, Switzerland / Brigham and Women's Hospital.Division of Infectious Disease. Boston, MA, USA.INSERM / Université Paris Diderot, IAM. Sorbonne Paris Cité / Hôpital Bichat. Services de Maladies Infectieuses et Tropicales. Paris, France.The research agenda towards an HIV cure is building rapidly. In this article, we discuss the reasons for and methodological approach to using mathematical modelling and cost-effectiveness analysis in this agenda. We provide a brief description of the proof of concept for cure and the current directions of cure research. We then review the types of clinical economic evaluations, including cost analysis, cost-benefit analysis and cost-effectiveness analysis. We describe the use of mathematical modelling and cost-effectiveness analysis early in the HIV epidemic as well as in the era of combination antiretroviral therapy. We then highlight the novel methodology of Value of Information (VOI) analysis and its potential role in the planning of clinical trials. We close with recommendations for modelling and cost-effectiveness analysis in the HIV cure agenda.engThe HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIV/AIDSCost-effectivenessCureMathematical modelinginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32306/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALF124-jve-1-245.pdfapplication/pdf80246https://www.arca.fiocruz.br/bitstream/icict/32306/2/F124-jve-1-245.pdf94521f854ca04bc4e2ab2c238b6ef46bMD52TEXTF124-jve-1-245.pdf.txtF124-jve-1-245.pdf.txtExtracted texttext/plain37609https://www.arca.fiocruz.br/bitstream/icict/32306/3/F124-jve-1-245.pdf.txtb366085add0f00075ede518eca5db2a4MD53icict/323062019-04-13 13:03:49.915oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-13T16:03:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
title The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
spellingShingle The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
Freedberg, Kenneth A.
HIV/AIDS
Cost-effectiveness
Cure
Mathematical modeling
title_short The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
title_full The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
title_fullStr The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
title_full_unstemmed The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
title_sort The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis
author Freedberg, Kenneth A.
author_facet Freedberg, Kenneth A.
Possas, Cristina
Deeks, Steven
Ross, Anna Laura
Rosettie, Katherine L.
Mascio, Michele Di
Collins, Chris
Walensky, Rochelle P.
Yazdanpanah, Yazdan
author_role author
author2 Possas, Cristina
Deeks, Steven
Ross, Anna Laura
Rosettie, Katherine L.
Mascio, Michele Di
Collins, Chris
Walensky, Rochelle P.
Yazdanpanah, Yazdan
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freedberg, Kenneth A.
Possas, Cristina
Deeks, Steven
Ross, Anna Laura
Rosettie, Katherine L.
Mascio, Michele Di
Collins, Chris
Walensky, Rochelle P.
Yazdanpanah, Yazdan
dc.subject.en.pt_BR.fl_str_mv HIV/AIDS
Cost-effectiveness
Cure
Mathematical modeling
topic HIV/AIDS
Cost-effectiveness
Cure
Mathematical modeling
description For the International AIDS Society Working Group on Cost-Effectiveness: Towards an HIV Cure Initiative.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-03-29T19:37:13Z
dc.date.available.fl_str_mv 2019-03-29T19:37:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREEDBERG, Kenneth A. et al. The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis. Journal Of Virus Eradication, London, v. 4, n. 1, p. 245-249, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32306
dc.identifier.issn.pt_BR.fl_str_mv 2055-6640
identifier_str_mv FREEDBERG, Kenneth A. et al. The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis. Journal Of Virus Eradication, London, v. 4, n. 1, p. 245-249, 2015.
2055-6640
url https://www.arca.fiocruz.br/handle/icict/32306
dc.language.iso.fl_str_mv eng
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