Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno de Bezerril
Data de Publicação: 2010
Outros Autores: Reis Filho, Antonio José Souza, Souza Neto, Sebastião Martins, Raffaele Netto, Imbroinise, Camargo, Luís Marcelo Aranha, Barral, Aldina Maria Prado, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7378
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
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spelling Andrade, Bruno de BezerrilReis Filho, Antonio José SouzaSouza Neto, Sebastião MartinsRaffaele Netto, ImbroiniseCamargo, Luís Marcelo AranhaBarral, Aldina Maria PradoBarral Netto, Manoel2014-03-06T17:29:04Z2014-03-06T17:29:04Z2010ANDRADE, B. B. et al. Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity. Plos Neglected Tropical Diseases, v. 4, p. e650, 2010.1935-273510.1371/journal.pntd.0000650https://www.arca.fiocruz.br/handle/icict/7378engNew York University School of MedicinePlasma superoxide dismutase-1 as a surrogate marker of vivax malaria severityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Faculdade de Medicina. Faculdade São Lucas. Porto Velho, RO, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia (INCT). Instituto de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia (INCT). Instituto de Investigação em Imunologia. São Paulo, SP, BrasilSevere outcomes have been described for both Plasmodium falciparum and P. vivax infections. The identification of sensitive and reliable markers of disease severity is fundamental to improving patient care. An intense pro-inflammatory response with oxidative stress and production of reactive oxygen species is present in malaria. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and antioxidant agents such as superoxide dismutase-1 (SOD-1) are likely candidate biomarkers for disease severity. Here we tested whether plasma levels of SOD-1 could serve as a biomarker of severe vivax malaria. METHODOLOGY/PRINCIPAL FINDINGS: Plasma samples were obtained from residents of the Brazilian Amazon with a high risk for P. vivax transmission. Malaria diagnosis was made by both microscopy and nested PCR. A total of 219 individuals were enrolled: non-infected volunteers (n = 90) and individuals with vivax malaria: asymptomatic (n = 60), mild (n = 50) and severe infection (n = 19). SOD-1 was directly associated with parasitaemia, plasma creatinine and alanine amino-transaminase levels, while TNF-alpha correlated only with the later enzyme. The predictive power of SOD-1 and TNF-alpha levels was compared. SOD-1 protein levels were more effective at predicting vivax malaria severity than TNF-alpha. For discrimination of mild infection, elevated SOD-1 levels showed greater sensitivity than TNF-alpha (76% vs. 30% respectively; p<0.0001), with higher specificity (100% vs. 97%; p<0.0001). In predicting severe vivax malaria, SOD-1 levels exhibited higher sensitivity than TNF-alpha (80% vs. 56%, respectively; p<0.0001; likelihood ratio: 7.45 vs. 3.14; p<0.0001). Neither SOD-1 nor TNF-alpha could discriminate P. vivax infections from those caused by P. falciparum. CONCLUSION: SOD-1 is a powerful predictor of disease severity in individuals with different clinical presentations of vivax malaria.Malária Vivax/diagnósticoMalária Vivax/patologiaSuperóxido Dismutase/sangueAdolescenteAdultoAnimaisMarcadores BiológicosBrasilFemininoHumanosMasculinoMicroscopiaMeia-IdadeParasitemiaPlasma/químicaPlasmodium vivax/imunologiaPlasmodium vivax/isolamento & purificaçãoReação em Cadeia da PolimeraseValor Preditivo dos TestesPrognósticoAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade BB Plasma Superoxide Dismutase-1....pdfAndrade BB Plasma Superoxide Dismutase-1....pdfapplication/pdf291130https://www.arca.fiocruz.br/bitstream/icict/7378/1/Andrade%20BB%20Plasma%20Superoxide%20Dismutase-1....pdf677a455bcfe34360693a66b11ac956cbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7378/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAndrade BB Plasma Superoxide Dismutase-1....pdf.txtAndrade BB Plasma Superoxide Dismutase-1....pdf.txtExtracted texttext/plain34389https://www.arca.fiocruz.br/bitstream/icict/7378/5/Andrade%20BB%20Plasma%20Superoxide%20Dismutase-1....pdf.txt35b849535f8db1ce465de7d7bade3f3bMD55THUMBNAILAndrade BB Plasma Superoxide Dismutase-1....pdf.jpgAndrade BB Plasma Superoxide Dismutase-1....pdf.jpgGenerated Thumbnailimage/jpeg2567https://www.arca.fiocruz.br/bitstream/icict/7378/4/Andrade%20BB%20Plasma%20Superoxide%20Dismutase-1....pdf.jpg56b214598750e41f9ca9102f3ce9ff9aMD54icict/73782023-03-15 14:33:27.464oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:27Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
title Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
spellingShingle Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
Andrade, Bruno de Bezerril
Malária Vivax/diagnóstico
Malária Vivax/patologia
Superóxido Dismutase/sangue
Adolescente
Adulto
Animais
Marcadores Biológicos
Brasil
Feminino
Humanos
Masculino
Microscopia
Meia-Idade
Parasitemia
Plasma/química
Plasmodium vivax/imunologia
Plasmodium vivax/isolamento & purificação
Reação em Cadeia da Polimerase
Valor Preditivo dos Testes
Prognóstico
Adulto Jovem
title_short Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
title_full Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
title_fullStr Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
title_full_unstemmed Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
title_sort Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity
author Andrade, Bruno de Bezerril
author_facet Andrade, Bruno de Bezerril
Reis Filho, Antonio José Souza
Souza Neto, Sebastião Martins
Raffaele Netto, Imbroinise
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Reis Filho, Antonio José Souza
Souza Neto, Sebastião Martins
Raffaele Netto, Imbroinise
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno de Bezerril
Reis Filho, Antonio José Souza
Souza Neto, Sebastião Martins
Raffaele Netto, Imbroinise
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv Malária Vivax/diagnóstico
Malária Vivax/patologia
Superóxido Dismutase/sangue
Adolescente
Adulto
Animais
Marcadores Biológicos
Brasil
Feminino
Humanos
Masculino
Microscopia
Meia-Idade
Parasitemia
Plasma/química
Plasmodium vivax/imunologia
Plasmodium vivax/isolamento & purificação
Reação em Cadeia da Polimerase
Valor Preditivo dos Testes
Prognóstico
Adulto Jovem
topic Malária Vivax/diagnóstico
Malária Vivax/patologia
Superóxido Dismutase/sangue
Adolescente
Adulto
Animais
Marcadores Biológicos
Brasil
Feminino
Humanos
Masculino
Microscopia
Meia-Idade
Parasitemia
Plasma/química
Plasmodium vivax/imunologia
Plasmodium vivax/isolamento & purificação
Reação em Cadeia da Polimerase
Valor Preditivo dos Testes
Prognóstico
Adulto Jovem
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-03-06T17:29:04Z
dc.date.available.fl_str_mv 2014-03-06T17:29:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, B. B. et al. Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity. Plos Neglected Tropical Diseases, v. 4, p. e650, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7378
dc.identifier.issn.none.fl_str_mv 1935-2735
10.1371/journal.pntd.0000650
identifier_str_mv ANDRADE, B. B. et al. Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity. Plos Neglected Tropical Diseases, v. 4, p. e650, 2010.
1935-2735
10.1371/journal.pntd.0000650
url https://www.arca.fiocruz.br/handle/icict/7378
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv New York University School of Medicine
publisher.none.fl_str_mv New York University School of Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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