A word of caution in interpreting Covid-19 diagnostics tests

Detalhes bibliográficos
Autor(a) principal: Silva, Severino Jefferson Ribeiro da
Data de Publicação: 2020
Outros Autores: Pena, Lindomar José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43566
Resumo: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.
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spelling Silva, Severino Jefferson Ribeiro daPena, Lindomar José2020-09-23T14:15:17Z2020-09-23T14:15:17Z2020SILVA, Severino Jefferson Ribeiro da; PENA, Lindomar José. A word of caution in interpreting Covid-19 diagnostics tests. Journal of Medical Virology, p. 1-6, 19 Set. 2020.0146-6615https://www.arca.fiocruz.br/handle/icict/4356610.1002/jmv.265311096-9071This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.Inclui carta do editor.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Since the emergence of SARS-CoV-2, many diagnostic tests including molecular and serological assays have been developed and approved by the Food and Drug Administration (FDA) for diagnosis of Covid-19. However, concerns about the sensitivity and specificity of many diagnostic assays, especially the rapid tests, have been raised. Diagnostic tests with unacceptable rates of false positive and false negative results interferes with therapeutic management of patients and can bring serious implications for public health authorities in the decision-making process regarding Covid-19 control. In this context, understanding key concepts in terms of development and validation of diagnostic assays is crucial for correct interpretation of test results. The parameters for validating diagnostic tests include analytical sensitivity, analytical specificity, clinical sensitivity, clinical specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value (PPV), negative predictive value (NPV), repeatability, reproducibility, and accuracy (Table 1). After initial development and optimization of a new Covid-19 test, the performance of the assay should be assessed using a set of well-defined clinical samples taking into account the required sample size. Ideally, data used for validation of Covid-19 test should be published in a peer-reviewed publication to allow independent evaluation.engWileyBioestatísticaBioinformáticaEpidemiologiaPandemiaSARS coronavirusEstatísticas de testeCOVID-19SARS-CoV-2Classificação de vírusBiostatisticsBioinformaticsEpidemiologyPandemicsSARS coronavirusTest statisticsCOVID-19SARS-CoV-2Virus classificationA word of caution in interpreting Covid-19 diagnostics testsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSimPublicadoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en.fl_str_mv A word of caution in interpreting Covid-19 diagnostics tests
title A word of caution in interpreting Covid-19 diagnostics tests
spellingShingle A word of caution in interpreting Covid-19 diagnostics tests
Silva, Severino Jefferson Ribeiro da
Bioestatística
Bioinformática
Epidemiologia
Pandemia
SARS coronavirus
Estatísticas de teste
COVID-19
SARS-CoV-2
Classificação de vírus
Biostatistics
Bioinformatics
Epidemiology
Pandemics
SARS coronavirus
Test statistics
COVID-19
SARS-CoV-2
Virus classification
title_short A word of caution in interpreting Covid-19 diagnostics tests
title_full A word of caution in interpreting Covid-19 diagnostics tests
title_fullStr A word of caution in interpreting Covid-19 diagnostics tests
title_full_unstemmed A word of caution in interpreting Covid-19 diagnostics tests
title_sort A word of caution in interpreting Covid-19 diagnostics tests
author Silva, Severino Jefferson Ribeiro da
author_facet Silva, Severino Jefferson Ribeiro da
Pena, Lindomar José
author_role author
author2 Pena, Lindomar José
author2_role author
dc.contributor.author.fl_str_mv Silva, Severino Jefferson Ribeiro da
Pena, Lindomar José
dc.subject.other.pt_BR.fl_str_mv Bioestatística
Bioinformática
Epidemiologia
Pandemia
SARS coronavirus
Estatísticas de teste
COVID-19
SARS-CoV-2
Classificação de vírus
topic Bioestatística
Bioinformática
Epidemiologia
Pandemia
SARS coronavirus
Estatísticas de teste
COVID-19
SARS-CoV-2
Classificação de vírus
Biostatistics
Bioinformatics
Epidemiology
Pandemics
SARS coronavirus
Test statistics
COVID-19
SARS-CoV-2
Virus classification
dc.subject.en.en.fl_str_mv Biostatistics
Bioinformatics
Epidemiology
Pandemics
SARS coronavirus
Test statistics
COVID-19
SARS-CoV-2
dc.subject.en.pt_BR.fl_str_mv Virus classification
description This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-23T14:15:17Z
dc.date.available.fl_str_mv 2020-09-23T14:15:17Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Severino Jefferson Ribeiro da; PENA, Lindomar José. A word of caution in interpreting Covid-19 diagnostics tests. Journal of Medical Virology, p. 1-6, 19 Set. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43566
dc.identifier.issn.pt_BR.fl_str_mv 0146-6615
dc.identifier.doi.pt_BR.fl_str_mv 10.1002/jmv.26531
dc.identifier.eissn.pt_BR.fl_str_mv 1096-9071
identifier_str_mv SILVA, Severino Jefferson Ribeiro da; PENA, Lindomar José. A word of caution in interpreting Covid-19 diagnostics tests. Journal of Medical Virology, p. 1-6, 19 Set. 2020.
0146-6615
10.1002/jmv.26531
1096-9071
url https://www.arca.fiocruz.br/handle/icict/43566
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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