Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission

Detalhes bibliográficos
Autor(a) principal: Benvenuto, Domenico
Data de Publicação: 2020
Outros Autores: Demir, Ayse Banu, Giovanetti, Marta, Bianchi, Martina, Angeletti, Silvia, Pascarella, Stefano, Cauda, Roberto, Ciccozzi, Massimo, Cassone, Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42436
Resumo: Acesso aberto em 28/07/2020 - https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26104
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spelling Benvenuto, DomenicoDemir, Ayse BanuGiovanetti, MartaBianchi, MartinaAngeletti, SilviaPascarella, StefanoCauda, RobertoCiccozzi, MassimoCassone, Antonio2020-07-28T20:06:13Z2020-07-28T20:06:13Z2020BENVENUTO, Domenico et al. Evidence for mutations in SARS‐CoV‐2 Italian isolates potentially affecting virus transmission. Journal of Medical Virology, p. 1-6, 2020.0146-6615https://www.arca.fiocruz.br/handle/icict/4243610.1002/jmv.261041096-9071Acesso aberto em 28/07/2020 - https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26104University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Izmir University of Economics. Department of Medical Biology. Izmir, Turkey.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus; Rio de Janeiro, RJ, Brasil.University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.University of Rome “La Sapienza”. Department of Biochemical Sciences “A. Rossi Fanelli”. Rome, Italy.Fondazione Policlinico Universitario “A. Gemelli” IRCCS. Rome, Italy / Catholic University of Sacred Heart. Department of Healthcare Surveillance and Bioethics. Rome, Italy.University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University of Siena. Department of Genomics, Genetics and Biology. Siena, Italy.Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation.engWileyBioinformáticaCOVID-19Evolução molecularMutaçãoCoronavírus SARSSARS-CoV-2BioinformaticsCOVID-19Molecular evolutionMutationSARS coronavirusSARS-CoV-2Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
title Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
spellingShingle Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
Benvenuto, Domenico
Bioinformática
COVID-19
Evolução molecular
Mutação
Coronavírus SARS
SARS-CoV-2
Bioinformatics
COVID-19
Molecular evolution
Mutation
SARS coronavirus
SARS-CoV-2
title_short Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
title_full Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
title_fullStr Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
title_full_unstemmed Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
title_sort Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
author Benvenuto, Domenico
author_facet Benvenuto, Domenico
Demir, Ayse Banu
Giovanetti, Marta
Bianchi, Martina
Angeletti, Silvia
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
author_role author
author2 Demir, Ayse Banu
Giovanetti, Marta
Bianchi, Martina
Angeletti, Silvia
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenuto, Domenico
Demir, Ayse Banu
Giovanetti, Marta
Bianchi, Martina
Angeletti, Silvia
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
dc.subject.other.pt_BR.fl_str_mv Bioinformática
COVID-19
Evolução molecular
Mutação
Coronavírus SARS
SARS-CoV-2
topic Bioinformática
COVID-19
Evolução molecular
Mutação
Coronavírus SARS
SARS-CoV-2
Bioinformatics
COVID-19
Molecular evolution
Mutation
SARS coronavirus
SARS-CoV-2
dc.subject.en.pt_BR.fl_str_mv Bioinformatics
COVID-19
Molecular evolution
Mutation
SARS coronavirus
SARS-CoV-2
description Acesso aberto em 28/07/2020 - https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26104
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-28T20:06:13Z
dc.date.available.fl_str_mv 2020-07-28T20:06:13Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENVENUTO, Domenico et al. Evidence for mutations in SARS‐CoV‐2 Italian isolates potentially affecting virus transmission. Journal of Medical Virology, p. 1-6, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42436
dc.identifier.issn.pt_BR.fl_str_mv 0146-6615
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.26104
dc.identifier.eissn.none.fl_str_mv 1096-9071
identifier_str_mv BENVENUTO, Domenico et al. Evidence for mutations in SARS‐CoV‐2 Italian isolates potentially affecting virus transmission. Journal of Medical Virology, p. 1-6, 2020.
0146-6615
10.1002/jmv.26104
1096-9071
url https://www.arca.fiocruz.br/handle/icict/42436
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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