Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial

Detalhes bibliográficos
Autor(a) principal: Oliveira, Evelin Santos
Data de Publicação: 2013
Outros Autores: Marinho, Jamocyr Moura, Bessa, Theolis Costa Barbosa, Study group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20799
Resumo: Study group: Evelin S Oliveiraa,bevelinsoliveira@yahoo.com.br,Jaqueline S Rodriguesa,bjsrbiologa@gmail.com,Elisabete L Conceic¸ ãoa,bbetejc@aluno.bahia.fiocruz.br,Mauricio R Pedrosabmaupedrosa@yahoo.com.br,Antonio Luis de O A Petersenbpetersen.swe@gmail.com,Juliana P Bezerra de Menezesbjulianaperrone@gmail.com,Sergio Arrudabsa@bahia.fiocruz.br, Jamocyr M Marinhoc,djamocyr@uol.com.br,Manoel Barral-Nettoa,bmbarral@bahia.fiocruz.br,Theolis Barbosaa,b,*theolis@bahia.fiocruz.brurgently
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spelling Oliveira, Evelin SantosMarinho, Jamocyr MouraBessa, Theolis Costa BarbosaStudy group2017-08-29T13:13:07Z2017-08-29T13:13:07Z2013OLIVEIRA, E. S.; MARINHO, J. M.; BESSA, T. C. B. Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial. Vaccine, v. 31, p. 3778– 3782, 2013.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/2079910.1016/j.vaccine.2013.04.079Study group: Evelin S Oliveiraa,bevelinsoliveira@yahoo.com.br,Jaqueline S Rodriguesa,bjsrbiologa@gmail.com,Elisabete L Conceic¸ ãoa,bbetejc@aluno.bahia.fiocruz.br,Mauricio R Pedrosabmaupedrosa@yahoo.com.br,Antonio Luis de O A Petersenbpetersen.swe@gmail.com,Juliana P Bezerra de Menezesbjulianaperrone@gmail.com,Sergio Arrudabsa@bahia.fiocruz.br, Jamocyr M Marinhoc,djamocyr@uol.com.br,Manoel Barral-Nettoa,bmbarral@bahia.fiocruz.br,Theolis Barbosaa,b,*theolis@bahia.fiocruz.brurgentlyFundação de Amparo à Pesquisa do Estado da Bahia–FAPESB [Convênio 160/03] and Conselho Nacional de Desenvolvimento Científico e Tecnológico [Proc. Nr. 476860/2007-5]. JSR, MP and ELC have received scholarships from FAPESB, and ESO received a scholarship from Coordenação de Aperfeiç oamento de Pessoal de Nível Superior (CAPES).Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilStudy groupThe Bacille Calmette-Guérin (BCG) vaccine is the only vaccine currently available for tuberculosis, and it demonstrates variable efficacy against the disease. The assessment of new vaccine strategies is hindered by the small annual probability that an infected individual will develop tuberculosis, and the lack of simple and reliable surrogate markers of protection. The frequency of cytokine-producing T cells as well as the production of IFN-γ have been disputed as surrogate markers of protection. We evaluated the evolution of these immune parameters in a population from a high burden city where BCG revaccination has been shown to result in mild protection. We found that individuals whose in vitro IFN-γ responses to mycobacterial antigens had increased by more than 3.3-fold were more likely to maintain higher responses after 1 year and to show increased expansion of IFN-γ-producing T lymphocytes than those with lower or null increase of IFN-γ.engElsevierVacinas contra a tuberculoseProteçãoVacinaPopulaçãoTuberculosis vaccinesCorrelates of protectionVaccine evaluationHuman populationsInterferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
title Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
spellingShingle Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
Oliveira, Evelin Santos
Vacinas contra a tuberculose
Proteção
Vacina
População
Tuberculosis vaccines
Correlates of protection
Vaccine evaluation
Human populations
title_short Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
title_full Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
title_fullStr Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
title_full_unstemmed Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
title_sort Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial
author Oliveira, Evelin Santos
author_facet Oliveira, Evelin Santos
Marinho, Jamocyr Moura
Bessa, Theolis Costa Barbosa
Study group
author_role author
author2 Marinho, Jamocyr Moura
Bessa, Theolis Costa Barbosa
Study group
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Evelin Santos
Marinho, Jamocyr Moura
Bessa, Theolis Costa Barbosa
Study group
dc.subject.other.pt_BR.fl_str_mv Vacinas contra a tuberculose
Proteção
Vacina
População
topic Vacinas contra a tuberculose
Proteção
Vacina
População
Tuberculosis vaccines
Correlates of protection
Vaccine evaluation
Human populations
dc.subject.en.pt_BR.fl_str_mv Tuberculosis vaccines
Correlates of protection
Vaccine evaluation
Human populations
description Study group: Evelin S Oliveiraa,bevelinsoliveira@yahoo.com.br,Jaqueline S Rodriguesa,bjsrbiologa@gmail.com,Elisabete L Conceic¸ ãoa,bbetejc@aluno.bahia.fiocruz.br,Mauricio R Pedrosabmaupedrosa@yahoo.com.br,Antonio Luis de O A Petersenbpetersen.swe@gmail.com,Juliana P Bezerra de Menezesbjulianaperrone@gmail.com,Sergio Arrudabsa@bahia.fiocruz.br, Jamocyr M Marinhoc,djamocyr@uol.com.br,Manoel Barral-Nettoa,bmbarral@bahia.fiocruz.br,Theolis Barbosaa,b,*theolis@bahia.fiocruz.brurgently
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2017-08-29T13:13:07Z
dc.date.available.fl_str_mv 2017-08-29T13:13:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, E. S.; MARINHO, J. M.; BESSA, T. C. B. Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial. Vaccine, v. 31, p. 3778– 3782, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20799
dc.identifier.issn.pt_BR.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2013.04.079
identifier_str_mv OLIVEIRA, E. S.; MARINHO, J. M.; BESSA, T. C. B. Interferon-gamma production by mononuclear cells in Bacille Calmette-Guérin-revaccinated healthy volunteers predicted long-term antimycobacterial responses in a randomized controlled trial. Vaccine, v. 31, p. 3778– 3782, 2013.
0264-410X
10.1016/j.vaccine.2013.04.079
url https://www.arca.fiocruz.br/handle/icict/20799
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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