Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1038/s41598-023-31901-4 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58014 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Hospital Federal Servidores do Estado. Rio de janeiro, RJ, Brasill / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto. Comitê de Controle da Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. |
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Gomes, Marisa Zenaide RibeiroLima, Elisangela Martins deAires, Caio Augusto MartinsPereira, Polyana SilvaYim, JuwonSilva, Fernando HenriqueRodrigues, Caio Augusto SantosOliveira, Thamirys Rachel Tavares eSilva, Priscila Pinho daEller, Cristiane MonteiroSouza, Claudio Marcos Rocha deRybak, Michael J.Albano, Rodolpho MattosMiranda, Antonio Basílio deMachado, EdsonCatanho, MarcosNucleus of Hospital Research (NPH) study collaborators *2023-04-26T20:34:44Z2023-04-26T20:34:44Z2023GOMES, Marisa Zenaide Ribeiro et al. Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes. Scientific Report, v. 13: 6238, p. 1 - 19, 2023.2045-2322https://www.arca.fiocruz.br/handle/icict/5801410.1038/s41598-023-31901-4engNature PortfolioRelatório de surto de poly myx incar bap pneumoniae causando infecções intratáveis evidenciadas por testes de sinergia e genomas bacterianosOutbreak report of poly myx incar bap ene eneeumoniaeCausing untreatable infectionsEvidenced by synergy tests and bacterial genomesOutbreak report of poly myx incar bap ene Incar bap ene m‑r esistant Klebsiella pnOutbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Hospital Federal Servidores do Estado. Rio de janeiro, RJ, Brasill / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto. Comitê de Controle da Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Hospital Federal Servidores do Estado. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil / Departamento de Ciência da Saúde, Universidade Federal Rural do Semi-Árido (UFERSA). Mossoró, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Anti‑Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Department of Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, MI, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Hospital Federal Servidores do Estado. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.4Anti‑Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Department of Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, MI, USA.Universidade do Estado do Rio de Janeiro. Departamento de Bioquímica, IBRAG. Rio de janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.Polymyxin-carbapenem-resistant Klebsiella pneumoniae (PCR-Kp) with pan (PDR)- or extensively drugresistant phenotypes has been increasingly described worldwide. Here, we report a PCR-Kp outbreak causing untreatable infections descriptively correlated with bacterial genomes. Hospital-wide surveillance of PCR-Kp was initiated in December-2014, after the first detection of a K. pneumoniae phenotype initially classified as PDR, recovered from close spatiotemporal cases of a sentinel hospital in Rio de Janeiro. Whole-genome sequencing of clinical PCR-Kp was performed to investigate similarities and dissimilarities in phylogeny, resistance and virulence genes, plasmid structures and genetic polymorphisms. A target phenotypic profile was detected in 10% (12/117) of the tested K. pneumoniae complex bacteria recovered from patients (8.5%, 8/94) who had epidemiological links and were involved in intractable infections and death, with combined therapeutic drugs failing to meet synergy. Two resistant bacterial clades belong to the same transmission cluster (ST437) or might have different sources (ST11). The severity of infection was likely related to patients’ comorbidities, lack of antimicrobial therapy and predicted bacterial genes related to high resistance, survival, and proliferation. This report contributes to the actual knowledge about the natural history of PCR-Kp infection, while reporting from a time when there were no licensed drugs in the world to treat some of these infections. More studies comparing clinical findings with bacterial genetic markers during clonal spread are needed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMarisaGomes_EdsonMachado_etal_IOC_2023.pdfMarisaGomes_EdsonMachado_etal_IOC_2023.pdfapplication/pdf3353733https://www.arca.fiocruz.br/bitstream/icict/58014/2/MarisaGomes_EdsonMachado_etal_IOC_2023.pdfce6bc68be2a73d2e4ca6300ef47ae766MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58014/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/580142023-09-04 11:30:12.019oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:30:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| title |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| spellingShingle |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes Gomes, Marisa Zenaide Ribeiro Relatório de surto de poly myx incar bap pneumoniae causando infecções intratáveis evidenciadas por testes de sinergia e genomas bacterianos Outbreak report of poly myx incar bap ene eneeumoniae Causing untreatable infections Evidenced by synergy tests and bacterial genomes Outbreak report of poly myx incar bap ene Incar bap ene m‑r esistant Klebsiella pn |
| title_short |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| title_full |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| title_fullStr |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| title_full_unstemmed |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| title_sort |
Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes |
| author |
Gomes, Marisa Zenaide Ribeiro |
| author_facet |
Gomes, Marisa Zenaide Ribeiro Lima, Elisangela Martins de Aires, Caio Augusto Martins Pereira, Polyana Silva Yim, Juwon Silva, Fernando Henrique Rodrigues, Caio Augusto Santos Oliveira, Thamirys Rachel Tavares e Silva, Priscila Pinho da Eller, Cristiane Monteiro Souza, Claudio Marcos Rocha de Rybak, Michael J. Albano, Rodolpho Mattos Miranda, Antonio Basílio de Machado, Edson Catanho, Marcos Nucleus of Hospital Research (NPH) study collaborators * |
| author_role |
author |
| author2 |
Lima, Elisangela Martins de Aires, Caio Augusto Martins Pereira, Polyana Silva Yim, Juwon Silva, Fernando Henrique Rodrigues, Caio Augusto Santos Oliveira, Thamirys Rachel Tavares e Silva, Priscila Pinho da Eller, Cristiane Monteiro Souza, Claudio Marcos Rocha de Rybak, Michael J. Albano, Rodolpho Mattos Miranda, Antonio Basílio de Machado, Edson Catanho, Marcos Nucleus of Hospital Research (NPH) study collaborators * |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gomes, Marisa Zenaide Ribeiro Lima, Elisangela Martins de Aires, Caio Augusto Martins Pereira, Polyana Silva Yim, Juwon Silva, Fernando Henrique Rodrigues, Caio Augusto Santos Oliveira, Thamirys Rachel Tavares e Silva, Priscila Pinho da Eller, Cristiane Monteiro Souza, Claudio Marcos Rocha de Rybak, Michael J. Albano, Rodolpho Mattos Miranda, Antonio Basílio de Machado, Edson Catanho, Marcos Nucleus of Hospital Research (NPH) study collaborators * |
| dc.subject.other.en_US.fl_str_mv |
Relatório de surto de poly myx incar bap pneumoniae causando infecções intratáveis evidenciadas por testes de sinergia e genomas bacterianos |
| topic |
Relatório de surto de poly myx incar bap pneumoniae causando infecções intratáveis evidenciadas por testes de sinergia e genomas bacterianos Outbreak report of poly myx incar bap ene eneeumoniae Causing untreatable infections Evidenced by synergy tests and bacterial genomes Outbreak report of poly myx incar bap ene Incar bap ene m‑r esistant Klebsiella pn |
| dc.subject.en.en_US.fl_str_mv |
Outbreak report of poly myx incar bap ene eneeumoniae Causing untreatable infections Evidenced by synergy tests and bacterial genomes Outbreak report of poly myx incar bap ene Incar bap ene m‑r esistant Klebsiella pn |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Hospital Federal Servidores do Estado. Rio de janeiro, RJ, Brasill / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto. Comitê de Controle da Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-04-26T20:34:44Z |
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2023-04-26T20:34:44Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
GOMES, Marisa Zenaide Ribeiro et al. Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes. Scientific Report, v. 13: 6238, p. 1 - 19, 2023. |
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https://www.arca.fiocruz.br/handle/icict/58014 |
| dc.identifier.issn.en_US.fl_str_mv |
2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-023-31901-4 |
| identifier_str_mv |
GOMES, Marisa Zenaide Ribeiro et al. Outbreak report of p oly myx incar bap ene m‑r esistant Klebsiella pneumoniae causing untreatable infections evidenced by synergy tests and bacterial genomes. Scientific Report, v. 13: 6238, p. 1 - 19, 2023. 2045-2322 10.1038/s41598-023-31901-4 |
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https://www.arca.fiocruz.br/handle/icict/58014 |
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eng |
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openAccess |
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Nature Portfolio |
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Nature Portfolio |
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