Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Daltro, Cleidiane Borges
Data de Publicação: 2016
Outros Autores: Santos, Alice Sarno Martins dos, Mendes, Carlos Maurício Cardeal, Bessa, Theolis Costa Barbosa
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18007
Resumo: FAPESB
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spelling Daltro, Cleidiane BorgesSantos, Alice Sarno Martins dosMendes, Carlos Maurício CardealBessa, Theolis Costa Barbosa2017-03-10T17:24:33Z2017-03-10T17:24:33Z2016DALTRO, C. B. et al. Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis. . In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., Alagoas, 2016. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 9228.https://www.arca.fiocruz.br/handle/icict/18007FAPESBUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHLA-DRB1 is a polymorphic gene with approximately 500 allelic variants that is crucial for antigen presentation. This allelic diversity must be considered for the development of epitope-based vaccines. Brazil, Russian Federation, India, China and South Africa (BRICS) account for almost 50% of global TB cases and 40% of all TB-associated mortality. We describe the distribution of HLA-DRB1 alleles in these countries. Articles in Portuguese, English and Spanish, with free access or with access provided by Fundacao Oswaldo Cruz or the CAPES Consortium, reporting the allele frequency for HLA class II in humans present in the PubMed platform (June 2014 to March 2016) were included. Articles that only reported the HLA-DQ or/and DP frequencies, or that reported allele frequencies in restricted groups, or where the allelic frequencies could not be deduced accurately, studies limited to abstracts and those that did not report the full results for the alleles studied were excluded. Duplicate reports as well as preliminary data if a further report extended the sample size or provided additional data were also excluded. The methodological quality of the articles was assessed using an adapted "Newcastle-Ottawa Scale". The fixed effects model was considered if I2 ≤ 50% and the random effects model was considered if I2 > 50%. We included 15 articles from Brazil, 8 from Russia, 9 from India, 19 from China and 6 from South Africa. HLA-DRB1 *01; *03; *04; *07; *11; *13; *15 alleles were the most frequent among the populations studied. HLA-DRB1*15 (in all countries), DRB1*13 (in all countries except for China) and DRB1*07 (in all countries except for South Africa) were ≥ 10%. HLA-DRB1*09 and *12 were the most frequent in China in spite of being rare in other populations. Epitope-based vaccines with high affinity for these alleles would be capable of stimulating at least 80% of the population of the countries studied.engSociedade Brasileira de Medicina TropicalVacinaTuberculoseVaccinesPeptideTuberculosisDistribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject2016-08-21MaceióCongresso da Sociedade Brasileira de Medicina Tropicalbiennialinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18007/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDaltro CB 9228-Distribution-of-HLA-DRB1-alleles-in-countries-with-high-tuberculosis-burden-Brazil-Russia-India-China-and-S...pdfDaltro CB 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dc.title.pt_BR.fl_str_mv Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
title Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
spellingShingle Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
Daltro, Cleidiane Borges
Vacina
Tuberculose
Vaccines
Peptide
Tuberculosis
title_short Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
title_full Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
title_fullStr Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
title_full_unstemmed Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
title_sort Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis
author Daltro, Cleidiane Borges
author_facet Daltro, Cleidiane Borges
Santos, Alice Sarno Martins dos
Mendes, Carlos Maurício Cardeal
Bessa, Theolis Costa Barbosa
author_role author
author2 Santos, Alice Sarno Martins dos
Mendes, Carlos Maurício Cardeal
Bessa, Theolis Costa Barbosa
author2_role author
author
author
dc.contributor.author.fl_str_mv Daltro, Cleidiane Borges
Santos, Alice Sarno Martins dos
Mendes, Carlos Maurício Cardeal
Bessa, Theolis Costa Barbosa
dc.subject.other.pt_BR.fl_str_mv Vacina
Tuberculose
topic Vacina
Tuberculose
Vaccines
Peptide
Tuberculosis
dc.subject.en.pt_BR.fl_str_mv Vaccines
Peptide
Tuberculosis
description FAPESB
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-10T17:24:33Z
dc.date.available.fl_str_mv 2017-03-10T17:24:33Z
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dc.identifier.citation.fl_str_mv DALTRO, C. B. et al. Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis. . In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., Alagoas, 2016. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 9228.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18007
identifier_str_mv DALTRO, C. B. et al. Distribution of HLA-DRB1 alleles in countries with high tuberculosis burden (Brazil, Russia, India, China and South Africa): a systematic review and meta-analysis. . In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., Alagoas, 2016. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 9228.
url https://www.arca.fiocruz.br/handle/icict/18007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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