A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index

Detalhes bibliográficos
Autor(a) principal: Baptista, Abrahão Fontes
Data de Publicação: 2007
Outros Autores: Gomes, Joyce Rios de Souza, Oliveira, Júlia Teixeria, Santos, Soraia Moreira Garzedim, Santos, Marcos André Vannier dos, Martinez, Ana Maria Blanco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14758
Resumo: Universidade Federal do Rio de Janeiro. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil / Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Baptista, Abrahão FontesGomes, Joyce Rios de SouzaOliveira, Júlia TeixeriaSantos, Soraia Moreira GarzedimSantos, Marcos André Vannier dosMartinez, Ana Maria Blanco2016-07-04T17:54:15Z2016-07-07T19:04:23Z2016-07-04T17:54:15Z2016-07-07T19:04:23Z2007BAPTISTA, A. F. et al. A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index. Journal of Neuroscience Methods, v. 161, p. 259–264, 2007.0165-0270https://www.arca.fiocruz.br/handle/icict/14758engElsevierA new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static indexinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil / Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil.Among the numerous ways of assessing regeneration after peripheral nerve lesions, the analysis of gait is one of the most important, because it shows the recovery of function, which is the ultimate goal of the repair machinery. The sciatic function index was introduced as a method to assess reinnervation after an experimental sciatic nerve lesion, and was adapted to the mouse model. The sciatic static index (SSI), is more simple and practical to perform, and is not so influenced by gait’s velocity, but this method has not yet been adapted to the mouse model of sciatic lesion. We used 63 male Swiss mice (Mus musculus) to develop a formula to the sciatic static index in mice (SSIm). The animals were divided on three groups (control, transection and crush). They were evaluated at the preoperative and 7th, 14th, 21st, 28th, 35th and 42nd days postoperative by the ink track method (SFI), and by the acquisition of photographs of the plantar aspects of the injured and uninjured hind paws. The parameters evaluated were the 1–5 toe spread (TS), the 2–4 toe spread (ITS) and the distance between the tip of the third toe and the most posterior aspect of the paw (PL), on both methods. After verifying the temporal pattern of function, correlation and reproducibility of the measurements, we performed a multiple regression analysis using SFI values as dependent variable, and the TS, ITS and PL measured with the photo method as independent variables, and found the formula of the SSI for mice (SSIm). The three groups (control, transection and crush) had a characteristic pattern of dysfunction. The parameters measured in the ink and photo method had variable but significant correlations between them (P < 0.000), but photo method of measurement showed a better reproducibility. The correlation between SFI and SSIm showed a high correlation coefficient (r = 0.892, P < 0.000), and demonstrates that SSIm can be used as an alternative method to assess the functional status relative of sciatic nerve activity in mice.Functional testsMiceSciatic nerveSciatic function indexSciatic static indexinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBatista AF A new aproach to assess......pdf.txtBatista AF A new aproach to assess......pdf.txtExtracted texttext/plain30533https://www.arca.fiocruz.br/bitstream/icict/14758/4/Batista%20AF%20A%20new%20aproach%20to%20assess......pdf.txtf642238d7fa4d2895ade3d42be875500MD54ORIGINALBatista AF A new aproach to 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dc.title.pt_BR.fl_str_mv A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
title A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
spellingShingle A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
Baptista, Abrahão Fontes
Functional tests
Mice
Sciatic nerve
Sciatic function index
Sciatic static index
title_short A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
title_full A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
title_fullStr A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
title_full_unstemmed A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
title_sort A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index
author Baptista, Abrahão Fontes
author_facet Baptista, Abrahão Fontes
Gomes, Joyce Rios de Souza
Oliveira, Júlia Teixeria
Santos, Soraia Moreira Garzedim
Santos, Marcos André Vannier dos
Martinez, Ana Maria Blanco
author_role author
author2 Gomes, Joyce Rios de Souza
Oliveira, Júlia Teixeria
Santos, Soraia Moreira Garzedim
Santos, Marcos André Vannier dos
Martinez, Ana Maria Blanco
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Baptista, Abrahão Fontes
Gomes, Joyce Rios de Souza
Oliveira, Júlia Teixeria
Santos, Soraia Moreira Garzedim
Santos, Marcos André Vannier dos
Martinez, Ana Maria Blanco
dc.subject.en.pt_BR.fl_str_mv Functional tests
Mice
Sciatic nerve
Sciatic function index
Sciatic static index
topic Functional tests
Mice
Sciatic nerve
Sciatic function index
Sciatic static index
description Universidade Federal do Rio de Janeiro. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil / Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2016-07-04T17:54:15Z
2016-07-07T19:04:23Z
dc.date.available.fl_str_mv 2016-07-04T17:54:15Z
2016-07-07T19:04:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAPTISTA, A. F. et al. A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index. Journal of Neuroscience Methods, v. 161, p. 259–264, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14758
dc.identifier.issn.pt_BR.fl_str_mv 0165-0270
identifier_str_mv BAPTISTA, A. F. et al. A new approach to assess function after sciatic nerve lesion in the mouse: adaptation of the sciatic static index. Journal of Neuroscience Methods, v. 161, p. 259–264, 2007.
0165-0270
url https://www.arca.fiocruz.br/handle/icict/14758
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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