Fibrosis: a distinguishing feature in the pathology of neural leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35526 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
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Antunes, Sérgio Luiz GomesJardim, Márcia RodriguesVital, Robson TeixeiraPascarelli, Bernardo Miguel de OliveiraNery, José Augusto da CostaAmadeu, Thaís PortoSales, Anna MariaCosta, Eduardo Alves Freire daSarno, Euzenir Nunes2019-09-12T14:04:01Z2019-09-12T14:04:01Z2019ANTUNES, Sérgio Luiz Gomes et al. Fibrosis: a distinguishing feature in the pathology of neural leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114. p. 1-8, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3552610.1590/0074-027601900561678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzHanseníaseNeuropatiaFibroseLeprosyNeuropathyFibrosisFibrosis: a distinguishing feature in the pathology of neural leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.BACKGROUND Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES The present study describes the frequency of fibrosis along with its characterisation and pathogenic development. METHODS Six-hundred-and-thirteen nerve samples were sorted from 278 neural leprosy (NL) and 335 non-leprosy neuropathy patients (ON). The total number of samples was histologically examined by routine staining methods (haematoxylin-eosin, Wade staining and Gomori’s trichrome) and fibrosis was evaluated via semi-quantitative estimation. FINDINGS Fibrosis was most frequent in the NL group (33% against 0.4% in ON) while fibrosis in association with endoneurial microfasciculation was found in 38 (41.3%) of the NL samples in the examination of semithin sections. Pericytic activation in the perivascular environment was confirmed to be the source of the fibroblasts and perineurial cells delimiting microfascicles. Endstage fibrosis in leprosy displays an arrangement of microfascicles devoid of neural components (i.e., Schwann cells and axons) lined by an intermediate phenotype of fibroblastic-perineurial cells filled with bundles of collagen fibres. MAIN CONCLUSIONS The present study underscores that fibrosis is frequently the severe end stage of neural leprosy NL pathogeny after analysing the notably distinct development of fibrosis within the neural environment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35526/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEuzenirSarno_BMOPascarelli_etal_IOC_2019.pdfEuzenirSarno_BMOPascarelli_etal_IOC_2019.pdfapplication/pdf7012036https://www.arca.fiocruz.br/bitstream/icict/35526/2/EuzenirSarno_BMOPascarelli_etal_IOC_2019.pdf80a91976cc25ebbc73588d8930a7eac4MD52TEXTEuzenirSarno_BMOPascarelli_etal_IOC_2019.pdf.txtEuzenirSarno_BMOPascarelli_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| title |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| spellingShingle |
Fibrosis: a distinguishing feature in the pathology of neural leprosy Antunes, Sérgio Luiz Gomes Hanseníase Neuropatia Fibrose Leprosy Neuropathy Fibrosis |
| title_short |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| title_full |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| title_fullStr |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| title_full_unstemmed |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| title_sort |
Fibrosis: a distinguishing feature in the pathology of neural leprosy |
| author |
Antunes, Sérgio Luiz Gomes |
| author_facet |
Antunes, Sérgio Luiz Gomes Jardim, Márcia Rodrigues Vital, Robson Teixeira Pascarelli, Bernardo Miguel de Oliveira Nery, José Augusto da Costa Amadeu, Thaís Porto Sales, Anna Maria Costa, Eduardo Alves Freire da Sarno, Euzenir Nunes |
| author_role |
author |
| author2 |
Jardim, Márcia Rodrigues Vital, Robson Teixeira Pascarelli, Bernardo Miguel de Oliveira Nery, José Augusto da Costa Amadeu, Thaís Porto Sales, Anna Maria Costa, Eduardo Alves Freire da Sarno, Euzenir Nunes |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Antunes, Sérgio Luiz Gomes Jardim, Márcia Rodrigues Vital, Robson Teixeira Pascarelli, Bernardo Miguel de Oliveira Nery, José Augusto da Costa Amadeu, Thaís Porto Sales, Anna Maria Costa, Eduardo Alves Freire da Sarno, Euzenir Nunes |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Neuropatia Fibrose |
| topic |
Hanseníase Neuropatia Fibrose Leprosy Neuropathy Fibrosis |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Neuropathy Fibrosis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
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2019 |
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2019-09-12T14:04:01Z |
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2019-09-12T14:04:01Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ANTUNES, Sérgio Luiz Gomes et al. Fibrosis: a distinguishing feature in the pathology of neural leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114. p. 1-8, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35526 |
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0074-0276 |
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10.1590/0074-02760190056 |
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1678-8060 |
| identifier_str_mv |
ANTUNES, Sérgio Luiz Gomes et al. Fibrosis: a distinguishing feature in the pathology of neural leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114. p. 1-8, 2019. 0074-0276 10.1590/0074-02760190056 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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