Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58090 |
Resumo: | Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil. |
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Formiga, Rodrigo de OliveiraAmaral, Flávia C.Souza, Camila F.Mendes, Daniel A. G. B.Wanderley, Carlos W. S.Lorenzini, Cristina B.Santos, Adara A.Antônia, JulianaFarias, Lucas F.Natale, Caio C.Paula, Nicholas M.Silva, Patricia C. S.Fonseca, Fernanda R.Aires, LuanHeck, NicoleStarick, Márick R.Queiroz-Junior, Celso M.Santos, Felipe R. S.Souza, Filipe R. O. deCosta, VivianMorrto, AlexandreVan Weyenbergh, JohanSordi, ReginaSilva, Frederico AlissonCunha, Fernando Q.Rocha, Edroaldo L.Chollet-Martin, SilvieHurtado-Nedelec, Maria MargaritaMartin, ClémenceBurgel, Pierre-RégisMansur, Daniel S.Maurici, RosemeriMacauley, Matthew S.Báfica, AndréWitko-Sarsat, VéroniqueSpiller, Fernando2023-04-30T14:53:39Z2023-04-30T14:53:39Z2022FORMIGA, Rodrigo de Oliveira et al. Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19. British Pharmacological Society, p. 1-22, 2023.1476-5381https://www.arca.fiocruz.br/handle/icict/5809010.1111/bph.16013engBritish Pharmacological SocietyCOVID-19SARS-CoV-2SepsisMetalloproteinase-9NeuraminidaseNeutrófiloÁcido siálicoZanamivirOseltamivirSepseCOVID-19Metalloproteinase-9NeuraminidaseNeutrophilSARS-CoV-2Sialic acidZanamivirOseltamivirSepsisNeuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Clínica Médica. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Hospital Naval Marcilio Dias. Instituto de Pesquisa Biomédica. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.INSERM-U1149, Faculté de Médecine, Site Xavier Bichat, CNRS, Université de Paris, Paris, France.Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France / Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France.Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France / Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Clínica Médica. Florianópolis, SC, Brasil.Department of Chemistry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil.Background and Purpose: Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen-derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regulate the neutrophil dysregulation observed in severe infections. Experimental Approach: The effects of NEU inhibitors on lipopolysaccharide (LPS)- stimulated neutrophils from healthy donors or COVID-19 patients were determined by evaluating the shedding of surface sialic acids, cell activation, and reactive oxygen species (ROS) production. Re-analysis of single-cell RNA sequencing of respiratory tract samples from COVID-19 patients also was carried out. The effects of oseltamivir on sepsis and betacoronavirus-induced acute lung injury were evaluated in murine models. Key Results: Oseltamivir and zanamivir constrained host NEU activity, surface sialic acid release, cell activation, and ROS production by LPS-activated human neutrophils. Mechanistically, LPS increased the interaction of NEU1 with matrix metalloproteinase 9 (MMP-9). Inhibition of MMP-9 prevented LPS-induced NEU activity and neutrophil response. In vivo, treatment with oseltamivir fine-tuned neutrophil migration and improved infection control as well as host survival in peritonitis and pneumonia sepsis. NEU1 also is highly expressed in neutrophils from COVID-19 patients, and treatment of whole-blood samples from these patients with either oseltamivir or zanamivir reduced neutrophil overactivation. Oseltamivir treatment of intranasally infected mice with the mouse hepatitis coronavirus 3 (MHV-3) decreased lung neutrophil infiltration, viral load, and tissue damage. Conclusion and Implications: These findings suggest that interplay of NEU1–MMP-9 induces neutrophil overactivation. In vivo, NEU may serve as a host-directed target to dampen neutrophil dysfunction during severe infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58090/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlexandreMorrot_etal_IOC_2022.pdfAlexandreMorrot_etal_IOC_2022.pdfapplication/pdf5816101https://www.arca.fiocruz.br/bitstream/icict/58090/2/AlexandreMorrot_etal_IOC_2022.pdf0939cad3288136dbe54d5faf10908bcbMD52icict/580902023-09-14 15:37:36.126oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:37:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| title |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| spellingShingle |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 Formiga, Rodrigo de Oliveira COVID-19 SARS-CoV-2 Sepsis Metalloproteinase-9 Neuraminidase Neutrófilo Ácido siálico Zanamivir Oseltamivir Sepse COVID-19 Metalloproteinase-9 Neuraminidase Neutrophil SARS-CoV-2 Sialic acid Zanamivir Oseltamivir Sepsis |
| title_short |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| title_full |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| title_fullStr |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| title_full_unstemmed |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| title_sort |
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19 |
| author |
Formiga, Rodrigo de Oliveira |
| author_facet |
Formiga, Rodrigo de Oliveira Amaral, Flávia C. Souza, Camila F. Mendes, Daniel A. G. B. Wanderley, Carlos W. S. Lorenzini, Cristina B. Santos, Adara A. Antônia, Juliana Farias, Lucas F. Natale, Caio C. Paula, Nicholas M. Silva, Patricia C. S. Fonseca, Fernanda R. Aires, Luan Heck, Nicole Starick, Márick R. Queiroz-Junior, Celso M. Santos, Felipe R. S. Souza, Filipe R. O. de Costa, Vivian Morrto, Alexandre Van Weyenbergh, Johan Sordi, Regina Silva, Frederico Alisson Cunha, Fernando Q. Rocha, Edroaldo L. Chollet-Martin, Silvie Hurtado-Nedelec, Maria Margarita Martin, Clémence Burgel, Pierre-Régis Mansur, Daniel S. Maurici, Rosemeri Macauley, Matthew S. Báfica, André Witko-Sarsat, Véronique Spiller, Fernando |
| author_role |
author |
| author2 |
Amaral, Flávia C. Souza, Camila F. Mendes, Daniel A. G. B. Wanderley, Carlos W. S. Lorenzini, Cristina B. Santos, Adara A. Antônia, Juliana Farias, Lucas F. Natale, Caio C. Paula, Nicholas M. Silva, Patricia C. S. Fonseca, Fernanda R. Aires, Luan Heck, Nicole Starick, Márick R. Queiroz-Junior, Celso M. Santos, Felipe R. S. Souza, Filipe R. O. de Costa, Vivian Morrto, Alexandre Van Weyenbergh, Johan Sordi, Regina Silva, Frederico Alisson Cunha, Fernando Q. Rocha, Edroaldo L. Chollet-Martin, Silvie Hurtado-Nedelec, Maria Margarita Martin, Clémence Burgel, Pierre-Régis Mansur, Daniel S. Maurici, Rosemeri Macauley, Matthew S. Báfica, André Witko-Sarsat, Véronique Spiller, Fernando |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Formiga, Rodrigo de Oliveira Amaral, Flávia C. Souza, Camila F. Mendes, Daniel A. G. B. Wanderley, Carlos W. S. Lorenzini, Cristina B. Santos, Adara A. Antônia, Juliana Farias, Lucas F. Natale, Caio C. Paula, Nicholas M. Silva, Patricia C. S. Fonseca, Fernanda R. Aires, Luan Heck, Nicole Starick, Márick R. Queiroz-Junior, Celso M. Santos, Felipe R. S. Souza, Filipe R. O. de Costa, Vivian Morrto, Alexandre Van Weyenbergh, Johan Sordi, Regina Silva, Frederico Alisson Cunha, Fernando Q. Rocha, Edroaldo L. Chollet-Martin, Silvie Hurtado-Nedelec, Maria Margarita Martin, Clémence Burgel, Pierre-Régis Mansur, Daniel S. Maurici, Rosemeri Macauley, Matthew S. Báfica, André Witko-Sarsat, Véronique Spiller, Fernando |
| dc.subject.other.en_US.fl_str_mv |
COVID-19 SARS-CoV-2 Sepsis Metalloproteinase-9 Neuraminidase Neutrófilo Ácido siálico Zanamivir Oseltamivir Sepse |
| topic |
COVID-19 SARS-CoV-2 Sepsis Metalloproteinase-9 Neuraminidase Neutrófilo Ácido siálico Zanamivir Oseltamivir Sepse COVID-19 Metalloproteinase-9 Neuraminidase Neutrophil SARS-CoV-2 Sialic acid Zanamivir Oseltamivir Sepsis |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 Metalloproteinase-9 Neuraminidase Neutrophil SARS-CoV-2 Sialic acid Zanamivir Oseltamivir Sepsis |
| description |
Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil / Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France / Universidade Federal de Santa Catarina. Departamento de Imunobiologia, Parasitologia e Microbiologia. Florianóplis, SC, Brasil. |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-04-30T14:53:39Z |
| dc.date.available.fl_str_mv |
2023-04-30T14:53:39Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
FORMIGA, Rodrigo de Oliveira et al. Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19. British Pharmacological Society, p. 1-22, 2023. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/58090 |
| dc.identifier.issn.en_US.fl_str_mv |
1476-5381 |
| dc.identifier.doi.none.fl_str_mv |
10.1111/bph.16013 |
| identifier_str_mv |
FORMIGA, Rodrigo de Oliveira et al. Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19. British Pharmacological Society, p. 1-22, 2023. 1476-5381 10.1111/bph.16013 |
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https://www.arca.fiocruz.br/handle/icict/58090 |
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eng |
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eng |
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openAccess |
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British Pharmacological Society |
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British Pharmacological Society |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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https://www.arca.fiocruz.br/bitstream/icict/58090/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/58090/2/AlexandreMorrot_etal_IOC_2022.pdf |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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