Cryptomeria japonica (L. F.) D. Don as source of shikimic acid

• Autor(a) principal: Cerdeira, Antonio Luiz
• Data de Publicação: 2020
• Outros Autores: Nascimento Queiroz, Sonia Claudia, Barifouse Matallo, Marcus
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/821
• topic: Influenza; Tamiflu; Oseltamivir phosphate; Neuraminidase; Influenza; Tamiflu; Oseltamivir; Neuraminidase

Oseltamivir phosphate (OSP), marketed under the brand name of Tamiflu®, is a potent inhibitor of viral neuraminidase, a glycoside hydrolase enzyme essential for viral replication. OSP is also important to control influenza virus (H1N1) and is produced mainly from shikimic acid (SA) extracted from plants. The main source of SA is from seeds of I. verum. Alternatives to meet the worldwide demand are necessary. One of this is Cryptomeria japonica. In this study, we found a content of 56.36 mg.kg-1 of SA in dried biomass for C. japonica, while for I.verum, the traditional source, was 96.57 mg.kg-1. Due to the fact of C. japonica is a tree, exploited for commercial production, it can be a renewable and reliable source SA for OSP production.