Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab

Detalhes bibliográficos
Autor(a) principal: Albuquerque, Aline de Oliveira
Data de Publicação: 2022
Outros Autores: Costa, Andrielly Henriques dos Santos, Andrade, Luca Milério, Sartori, Geraldo Rodrigues, Silva, João Hermínio Martins da
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52258
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Albuquerque, Aline de OliveiraCosta, Andrielly Henriques dos SantosAndrade, Luca MilérioSartori, Geraldo RodriguesSilva, João Hermínio Martins da2022-04-14T13:41:31Z2022-04-14T13:41:31Z2022ALBUQUERQUE, A. de O. et al. Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 45.https://www.arca.fiocruz.br/handle/icict/5225810.35259/isi.2022_52258Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosNotchCâncerAnticorposNotchCancerAntibodyNeoplasiasAnticorposConformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumabinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/52258/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALAnais6thISI2022_45.pdfAnais6thISI2022_45.pdfapplication/pdf142563https://www.arca.fiocruz.br/bitstream/icict/52258/2/Anais6thISI2022_45.pdf0400dd2451c6f9f35bb60058c80850e1MD52icict/522582023-04-26 16:56:20.846oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T19:56:20Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
title Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
spellingShingle Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
Albuquerque, Aline de Oliveira
Notch
Câncer
Anticorpos
Notch
Cancer
Antibody
Neoplasias
Anticorpos
title_short Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
title_full Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
title_fullStr Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
title_full_unstemmed Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
title_sort Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab
author Albuquerque, Aline de Oliveira
author_facet Albuquerque, Aline de Oliveira
Costa, Andrielly Henriques dos Santos
Andrade, Luca Milério
Sartori, Geraldo Rodrigues
Silva, João Hermínio Martins da
author_role author
author2 Costa, Andrielly Henriques dos Santos
Andrade, Luca Milério
Sartori, Geraldo Rodrigues
Silva, João Hermínio Martins da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Albuquerque, Aline de Oliveira
Costa, Andrielly Henriques dos Santos
Andrade, Luca Milério
Sartori, Geraldo Rodrigues
Silva, João Hermínio Martins da
dc.subject.other.pt_BR.fl_str_mv Notch
Câncer
Anticorpos
topic Notch
Câncer
Anticorpos
Notch
Cancer
Antibody
Neoplasias
Anticorpos
dc.subject.en.pt_BR.fl_str_mv Notch
Cancer
Antibody
dc.subject.decs.pt_BR.fl_str_mv Neoplasias
Anticorpos
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-04-14T13:41:31Z
dc.date.available.fl_str_mv 2022-04-14T13:41:31Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALBUQUERQUE, A. de O. et al. Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 45.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52258
dc.identifier.doi.none.fl_str_mv 10.35259/isi.2022_52258
identifier_str_mv ALBUQUERQUE, A. de O. et al. Conformational dynamics behind the inhibition of Notch1 NRR region by the antineoplastic antibody Brontictuzumab. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 45.
10.35259/isi.2022_52258
url https://www.arca.fiocruz.br/handle/icict/52258
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52258/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52258/2/Anais6thISI2022_45.pdf
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