Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2015
Outros Autores: Souza, Ligia C. L, Garcia, Gabriela Barreto Caldas, Magalhães, Belisa Maria Lopes, Gonçalves, Marilda de Souza, Lacerda, Marcus Vinícius Guimarães de, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13370
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA,
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spelling Mendonça, Vitor Rosa Ramos deSouza, Ligia C. LGarcia, Gabriela Barreto CaldasMagalhães, Belisa Maria LopesGonçalves, Marilda de SouzaLacerda, Marcus Vinícius Guimarães deBarral Netto, Manoel2016-03-28T17:59:35Z2016-03-28T17:59:35Z2015MENDONÇA, V. R. R. Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection. Malaria Journal, v.14, n. 1, p. 407-417, 2015.1475-287510.1186/s12936-015-0930-xhttps://www.arca.fiocruz.br/handle/icict/13370engBioMed CentralAssociations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA,Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA,Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, BrasilFundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto Nacional de Ciência e Tecnologia. São Paulo, SP, BrasilBACKGROUND: Hyperbilirubinaemia (bilirubin >51.3 µmol/L) alone is not indicative of severe malaria, and the immune response underlying hyperbilirubinaemia remains largely unexplored. Liver damage associated with hyperbilirubinaemia may alter the expression of hepcidin, which regulates systemic iron by degrading ferroportin. For this study, the association between hepcidin and the levels of cytokines and chemokines in the serum of individuals with mild and severe vivax malaria and subjects with malaria with isolated hyperbilirubinaemia was evaluated. METHODS: Cytokines/chemokines and hepcidin were measured in individuals with mild (n = 72) and severe (n = 17) vivax malaria, as well as in the serum of subjects with vivax malaria with isolated hyperbilirubinaemia (n = 14) from the Brazilian Amazon between 2009 and 2013 by multiplex assay and ELISA, respectively. The polymorphism 744 G > T in the ferroportin gene was identified by restriction fragment-length polymorphism analysis and the restriction enzyme PvuII. RESULTS: The polymorphism at position 744 G > T in the ferroportin gene was typed and no differences in the distributions of genotypes or alleles were observed between the study groups. Subjects with severe malaria had higher levels of interleukin (IL)-2 and IL-13 than subjects with hyperbilirubinaemia. No differences in the expression of immune markers were observed between subjects with mild malaria and those with hyperbilirubinaemia. However, hepcidin levels were higher in individuals with severe malaria and hyperbilirubinaemia than those with mild malaria (p = 0.0002 and p = 0.0004, respectively) and cut-off values of hepcidin differentiated these groups from subjects with mild malaria. Hepcidin was positively associated with IL-6 and IL-10 levels and with parasitaemia in subjects with mild malaria and with IFN-γ in subjects with severe malaria. CONCLUSIONS: Malaria in the presence of hyperbilirubinaemia produces a less robust inflammatory response compared to severe cases of malaria. Hepcidin levels are positively associated with immune markers in vivax malaria outcomes.MalariaPlasmodium vivaxImmune responseHepcidinHyperbilirubinemiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13370/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMendonça VRR Associations....pdfMendonça VRR Associations....pdfapplication/pdf1146023https://www.arca.fiocruz.br/bitstream/icict/13370/2/Mendon%c3%a7a%20VRR%20Associations....pdf7e4484a4253bc3b8c5d9af898cff74caMD52TEXTMendonça VRR Associations....pdf.txtMendonça VRR Associations....pdf.txtExtracted texttext/plain52682https://www.arca.fiocruz.br/bitstream/icict/13370/3/Mendon%c3%a7a%20VRR%20Associations....pdf.txtf919396ee0cce862e82a8c9a69ee11f6MD53icict/133702023-03-15 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dc.title.pt_BR.fl_str_mv Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
title Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
spellingShingle Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
Mendonça, Vitor Rosa Ramos de
Malaria
Plasmodium vivax
Immune response
Hepcidin
Hyperbilirubinemia
title_short Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
title_full Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
title_fullStr Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
title_full_unstemmed Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
title_sort Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Souza, Ligia C. L
Garcia, Gabriela Barreto Caldas
Magalhães, Belisa Maria Lopes
Gonçalves, Marilda de Souza
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
author_role author
author2 Souza, Ligia C. L
Garcia, Gabriela Barreto Caldas
Magalhães, Belisa Maria Lopes
Gonçalves, Marilda de Souza
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Souza, Ligia C. L
Garcia, Gabriela Barreto Caldas
Magalhães, Belisa Maria Lopes
Gonçalves, Marilda de Souza
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium vivax
Immune response
Hepcidin
Hyperbilirubinemia
topic Malaria
Plasmodium vivax
Immune response
Hepcidin
Hyperbilirubinemia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. Salvador, Ba, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA,
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-28T17:59:35Z
dc.date.available.fl_str_mv 2016-03-28T17:59:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R. R. Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection. Malaria Journal, v.14, n. 1, p. 407-417, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13370
dc.identifier.issn.none.fl_str_mv 1475-2875
10.1186/s12936-015-0930-x
identifier_str_mv MENDONÇA, V. R. R. Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection. Malaria Journal, v.14, n. 1, p. 407-417, 2015.
1475-2875
10.1186/s12936-015-0930-x
url https://www.arca.fiocruz.br/handle/icict/13370
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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