Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13976 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil |
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Mendonça, Vitor Rosa Ramos deAndrade, Bruno de BezerrilSouza, Ligia C LMagalhães, Belisa Maria LopesMourão, Maria Paula GomesLacerda, Marcus Vinícius Guimarães deBarral Netto, Manoel2016-04-26T17:32:23Z2016-04-26T17:32:23Z2015MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015.1475-2875https://www.arca.fiocruz.br/handle/icict/1397610.1186/s12936-015-0835-8engBioMed CentralUnravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, BrasilBackground: Concurrent malaria and dengue infection is frequently diagnosed in endemic countries, but its immunopathology remains largely unknown. In the present study, a large panel of cytokines/chemokines and clinical laboratory markers were measured in patients with Plasmodium vivax and dengue co-infection as well as in individuals with malaria or dengue mono-infections in order to identify biosignatures of each clinical condition. Methods: Individuals from the Brazilian Amazon were recruited between 2009 and 2013 and classified in three groups: vivax malaria (n = 52), dengue (n = 30) and vivax malaria and dengue co-infection (n = 30). P. vivax malaria was diagnosed by thick blood smear and confirmed by PCR; dengue cases were detected by IgM ELISA or NS1 protein. The plasma levels of cytokines and chemokines were determined by multiplex assay. Results: Individuals with malaria and dengue co-infection displayed lower levels of platelets and haemoglobin than those with malaria or dengue mono-infections (p = 0.0047 and p = 0.0001, respectively). The group of individuals coinfected exhibited the highest median concentrations of IFN-γ, IL-6, CCL4 than the mono-infected groups. Network analyses of plasma cytokines/chemokines revealed that malaria and dengue co-infection exhibits a distinct immune profile with critical roles for TNF, IL-6 and IFN-γ. Further, parasitaemia levels displayed positive significant interactions with IL-6, CCL4 and IL-10 in the group of patients co-infected with malaria and dengue. No differences were observed in distribution of dengue virus serotypes and Plasmodium parasitaemia levels between the groups. Conclusions: The findings described here identify unique patterns of circulating immunological markers in cases of malaria and dengue co-infection and provide insights on the immunopathology of this co-morbid condition.Immune responseCo-infectionDenguePlasmodium vivaxMalariainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13976/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMendonça VRR Unravelling the....pdfMendonça VRR Unravelling the....pdfapplication/pdf1769522https://www.arca.fiocruz.br/bitstream/icict/13976/2/Mendon%c3%a7a%20VRR%20Unravelling%20the....pdf9e588aa167adfadd6783622be1f69634MD52TEXTMendonça VRR Unravelling the....pdf.txtMendonça VRR Unravelling the....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
title |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
spellingShingle |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection Mendonça, Vitor Rosa Ramos de Immune response Co-infection Dengue Plasmodium vivax Malaria |
title_short |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
title_full |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
title_fullStr |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
title_full_unstemmed |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
title_sort |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection |
author |
Mendonça, Vitor Rosa Ramos de |
author_facet |
Mendonça, Vitor Rosa Ramos de Andrade, Bruno de Bezerril Souza, Ligia C L Magalhães, Belisa Maria Lopes Mourão, Maria Paula Gomes Lacerda, Marcus Vinícius Guimarães de Barral Netto, Manoel |
author_role |
author |
author2 |
Andrade, Bruno de Bezerril Souza, Ligia C L Magalhães, Belisa Maria Lopes Mourão, Maria Paula Gomes Lacerda, Marcus Vinícius Guimarães de Barral Netto, Manoel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mendonça, Vitor Rosa Ramos de Andrade, Bruno de Bezerril Souza, Ligia C L Magalhães, Belisa Maria Lopes Mourão, Maria Paula Gomes Lacerda, Marcus Vinícius Guimarães de Barral Netto, Manoel |
dc.subject.en.pt_BR.fl_str_mv |
Immune response Co-infection Dengue Plasmodium vivax Malaria |
topic |
Immune response Co-infection Dengue Plasmodium vivax Malaria |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-04-26T17:32:23Z |
dc.date.available.fl_str_mv |
2016-04-26T17:32:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13976 |
dc.identifier.issn.none.fl_str_mv |
1475-2875 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12936-015-0835-8 |
identifier_str_mv |
MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015. 1475-2875 10.1186/s12936-015-0835-8 |
url |
https://www.arca.fiocruz.br/handle/icict/13976 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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