Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27783 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil. |
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Calvet, Guilherme AmaralKara, Edna OliveiraGiozza, Silvana PereiraMenezes, Camila Helena Aguiar BôttoGaillard, PhilippeFranca, Rafael Freitas de OliveiraLacerda, Marcus Vinicius Guimarães deCastilho, Marcia da CostaBrasil, PatríciaSequeira, Patrícia Carvalho deMello, Maeve Brito deBermudez, Ximena Pamela DiazModjarrad, KayvonMeurant, RobynLandoulsi, SihemBenzaken, Adele SchwartzFilippis, Ana Maria Bispo deBroutet, Nathalie Jeanne Nicole2018-08-02T12:19:44Z2018-08-02T12:19:44Z2018CALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018.1471-2334https://www.arca.fiocruz.br/handle/icict/2778310.1186/s12879-018-2965-4engBioMed CentralArbovirusFlavivírusZika virusFluidos corporaisPersistênciaDoenças infecciosas emergentesReação em Cadeia da Polimerase em Tempo RealBrasilArbovirusFlavivirusZika virusBody fluidsPersistenceRt-PcrEmerging infectious diseasesBrazilReação em Cadeia da Polimerase em Tempo RealStudy on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil.World Health Organization. Geneva, Switzerland.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de. Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasília. DF, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil.World Health Organization. Geneva, Switzerland.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.World Health Organization. Pan American Health Organization. Department of Communicable Diseases and Health Analysis. Washingto, DC, USA.Universidade de Brasília. Departamento de Saúde Pública. Brasília, DF, Brasil / Organização Mundial de Saúde. Organização Pan Americana de Saúde. Brasília, DF, Brasil.Reed Army Institute of Research. Silver Spring, USA.World Health Organization. Geneva, Switzerland.World Health Organization. Geneva, Switzerland.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de. Vigilância, Prevenção e Controle das IST, do HIV/Aids e das Hepatites Virais. Brasília. DF, Brasil / Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.World Health Organization. Geneva, Switzerland.ZIKABRA Study Team.Background: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. Methods: This observational cohort study will recruit non-pregnant participants aged 18 years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. Discussion: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27783/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpatricia_sequeira_etal_IOC_2018.pdfpatricia_sequeira_etal_IOC_2018.pdfapplication/pdf466442https://www.arca.fiocruz.br/bitstream/icict/27783/2/patricia_sequeira_etal_IOC_2018.pdfe04c5a215ad73dbd9673a274c6a4de5bMD52TEXTpatricia_sequeira_etal_IOC_2018.pdf.txtpatricia_sequeira_etal_IOC_2018.pdf.txtExtracted texttext/plain86272https://www.arca.fiocruz.br/bitstream/icict/27783/3/patricia_sequeira_etal_IOC_2018.pdf.txt3cbafd2540c1c6c1785edf427836e035MD53icict/277832022-06-24 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| dc.title.pt_BR.fl_str_mv |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| title |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| spellingShingle |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil Calvet, Guilherme Amaral Arbovirus Flavivírus Zika virus Fluidos corporais Persistência Doenças infecciosas emergentes Reação em Cadeia da Polimerase em Tempo Real Brasil Arbovirus Flavivirus Zika virus Body fluids Persistence Rt-Pcr Emerging infectious diseases Brazil Reação em Cadeia da Polimerase em Tempo Real |
| title_short |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| title_full |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| title_fullStr |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| title_full_unstemmed |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| title_sort |
Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil |
| author |
Calvet, Guilherme Amaral |
| author_facet |
Calvet, Guilherme Amaral Kara, Edna Oliveira Giozza, Silvana Pereira Menezes, Camila Helena Aguiar Bôtto Gaillard, Philippe Franca, Rafael Freitas de Oliveira Lacerda, Marcus Vinicius Guimarães de Castilho, Marcia da Costa Brasil, Patrícia Sequeira, Patrícia Carvalho de Mello, Maeve Brito de Bermudez, Ximena Pamela Diaz Modjarrad, Kayvon Meurant, Robyn Landoulsi, Sihem Benzaken, Adele Schwartz Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole |
| author_role |
author |
| author2 |
Kara, Edna Oliveira Giozza, Silvana Pereira Menezes, Camila Helena Aguiar Bôtto Gaillard, Philippe Franca, Rafael Freitas de Oliveira Lacerda, Marcus Vinicius Guimarães de Castilho, Marcia da Costa Brasil, Patrícia Sequeira, Patrícia Carvalho de Mello, Maeve Brito de Bermudez, Ximena Pamela Diaz Modjarrad, Kayvon Meurant, Robyn Landoulsi, Sihem Benzaken, Adele Schwartz Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Calvet, Guilherme Amaral Kara, Edna Oliveira Giozza, Silvana Pereira Menezes, Camila Helena Aguiar Bôtto Gaillard, Philippe Franca, Rafael Freitas de Oliveira Lacerda, Marcus Vinicius Guimarães de Castilho, Marcia da Costa Brasil, Patrícia Sequeira, Patrícia Carvalho de Mello, Maeve Brito de Bermudez, Ximena Pamela Diaz Modjarrad, Kayvon Meurant, Robyn Landoulsi, Sihem Benzaken, Adele Schwartz Filippis, Ana Maria Bispo de Broutet, Nathalie Jeanne Nicole |
| dc.subject.other.pt_BR.fl_str_mv |
Arbovirus Flavivírus Zika virus Fluidos corporais Persistência Doenças infecciosas emergentes Reação em Cadeia da Polimerase em Tempo Real Brasil |
| topic |
Arbovirus Flavivírus Zika virus Fluidos corporais Persistência Doenças infecciosas emergentes Reação em Cadeia da Polimerase em Tempo Real Brasil Arbovirus Flavivirus Zika virus Body fluids Persistence Rt-Pcr Emerging infectious diseases Brazil Reação em Cadeia da Polimerase em Tempo Real |
| dc.subject.en.pt_BR.fl_str_mv |
Arbovirus Flavivirus Zika virus Body fluids Persistence Rt-Pcr Emerging infectious diseases Brazil |
| dc.subject.decs.pt_BR.fl_str_mv |
Reação em Cadeia da Polimerase em Tempo Real |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018-08-02T12:19:44Z |
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2018-08-02T12:19:44Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018. |
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https://www.arca.fiocruz.br/handle/icict/27783 |
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1471-2334 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12879-018-2965-4 |
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CALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018. 1471-2334 10.1186/s12879-018-2965-4 |
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BioMed Central |
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BioMed Central |
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