Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Barbosa, Cynara Gomes
Data de Publicação: 2008
Outros Autores: Souza, Claudio Lima, Moura Neto, José Pereira de, Arruda, Maria da Gloria Bomfim, Barreto, José Henrique Silva, Reis, Mitermayer Galvão dos, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6181
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
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spelling Barbosa, Cynara GomesSouza, Claudio LimaMoura Neto, José Pereira deArruda, Maria da Gloria BomfimBarreto, José Henrique SilvaReis, Mitermayer Galvão dosGonçalves, Marilda de Souza2013-01-14T18:12:51Z2013-01-14T18:12:51Z2008BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.1415-4757https://www.arca.fiocruz.br/handle/icict/6181engMethylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFaculdade de Medicina Edgard Santos. Hospital Universitário. Departamento de Hematologia. Salvador, Bahia, BrasilClinica Oncológica. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, BrasilMethylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigateMTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3AMLCMLMTHFR polymorphismsMetilenotetraidrofolato Redutase (NADPH2)Leucemia MielóideFrequência do GeneLeucemia Mielogênica Crônica BCR-ABL PositivaPolimorfismo de Fragmento de RestriçãoReação em Cadeia da PolimeraseMutaçãoHumanosMasculinoFemininoCriançaAdolescenteAdultoMeia-IdadeIdosoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarbosa, Cynara Gomes et al. Methylenetetrahydrofolate reductase....pdfBarbosa, Cynara Gomes et al. 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dc.title.pt_BR.fl_str_mv Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
spellingShingle Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
Barbosa, Cynara Gomes
AML
CML
MTHFR polymorphisms
Metilenotetraidrofolato Redutase (NADPH2)
Leucemia Mielóide
Frequência do Gene
Leucemia Mielogênica Crônica BCR-ABL Positiva
Polimorfismo de Fragmento de Restrição
Reação em Cadeia da Polimerase
Mutação
Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
title_short Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_full Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_fullStr Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_full_unstemmed Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_sort Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
author Barbosa, Cynara Gomes
author_facet Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Gloria Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author_role author
author2 Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Gloria Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Gloria Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
dc.subject.en.pt_BR.fl_str_mv AML
CML
MTHFR polymorphisms
topic AML
CML
MTHFR polymorphisms
Metilenotetraidrofolato Redutase (NADPH2)
Leucemia Mielóide
Frequência do Gene
Leucemia Mielogênica Crônica BCR-ABL Positiva
Polimorfismo de Fragmento de Restrição
Reação em Cadeia da Polimerase
Mutação
Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
dc.subject.decs.pt_BR.fl_str_mv Metilenotetraidrofolato Redutase (NADPH2)
Leucemia Mielóide
Frequência do Gene
Leucemia Mielogênica Crônica BCR-ABL Positiva
Polimorfismo de Fragmento de Restrição
Reação em Cadeia da Polimerase
Mutação
Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-01-14T18:12:51Z
dc.date.available.fl_str_mv 2013-01-14T18:12:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6181
dc.identifier.issn.none.fl_str_mv 1415-4757
identifier_str_mv BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.
1415-4757
url https://www.arca.fiocruz.br/handle/icict/6181
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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