Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35051 |
Resumo: | Faculdade de Educação e Cultura de Vilhena. Departamento de Biomedicina. Vilhena, RO, Brasil. |
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Oliveira, Flávio Augusto de SouzaPassarini, Guilherme MatosMedeiros, Daniel Sol Sol deSantos, Ana Paula de AzevedoFialho, Saara NeriGouveia, Aurileya de JesusLatorre, MarcineteFreitag, Elci MarleiMedeiros, Patrícia Soares de Maria deTeles, Carolina Bioni GarciaFacundo, Valdir Alves2019-08-23T20:41:30Z2019-08-23T20:41:30Z2018OLIVEIRA, Flávio Augusto de Souza et al. Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits, Revista da Sociedade Brasileira de Medicina Tropical, v. 51, p. 382-386, 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3505110.1590/0037-8682-0309-20171678-9849engRevista da Sociedade Brasileira de Medicina TropicalAntiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruitsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFaculdade de Educação e Cultura de Vilhena. Departamento de Biomedicina. Vilhena, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil.Fundação Universidade Federal de Rondônia. Departamento de Ciências Biológicas. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Centro Universitário São Lucas. Departamento de Ciências Biológicas. Porto Velho, RO, Brasil. / Instituto Nacional de Epidemiologia na Amazônia Ocidental. Porto Velho, RO, Brasil.Fundação Universidade Federal de Rondônia. Departamento de Química. Porto Velho, RO, Brasil.Introduction: This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. Methods: The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. Results: Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. Conclusions: The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.MalariaLeishmaniasisPiperBioactivityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35051/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAntiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruit.pdfAntiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruit.pdfapplication/pdf895929https://www.arca.fiocruz.br/bitstream/icict/35051/2/Antiplasmodial%20and%20antileishmanial%20activities%20of%20compounds%20from%20Piper%20tuberculatum%20Jacq%20fruit.pdfa9023ba4e6b21258c8e08d5dad647429MD52TEXTAntiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruit.pdf.txtAntiplasmodial and 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| dc.title.pt_BR.fl_str_mv |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| title |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| spellingShingle |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits Oliveira, Flávio Augusto de Souza Malaria Leishmaniasis Piper Bioactivity |
| title_short |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| title_full |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| title_fullStr |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| title_full_unstemmed |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| title_sort |
Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits |
| author |
Oliveira, Flávio Augusto de Souza |
| author_facet |
Oliveira, Flávio Augusto de Souza Passarini, Guilherme Matos Medeiros, Daniel Sol Sol de Santos, Ana Paula de Azevedo Fialho, Saara Neri Gouveia, Aurileya de Jesus Latorre, Marcinete Freitag, Elci Marlei Medeiros, Patrícia Soares de Maria de Teles, Carolina Bioni Garcia Facundo, Valdir Alves |
| author_role |
author |
| author2 |
Passarini, Guilherme Matos Medeiros, Daniel Sol Sol de Santos, Ana Paula de Azevedo Fialho, Saara Neri Gouveia, Aurileya de Jesus Latorre, Marcinete Freitag, Elci Marlei Medeiros, Patrícia Soares de Maria de Teles, Carolina Bioni Garcia Facundo, Valdir Alves |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Flávio Augusto de Souza Passarini, Guilherme Matos Medeiros, Daniel Sol Sol de Santos, Ana Paula de Azevedo Fialho, Saara Neri Gouveia, Aurileya de Jesus Latorre, Marcinete Freitag, Elci Marlei Medeiros, Patrícia Soares de Maria de Teles, Carolina Bioni Garcia Facundo, Valdir Alves |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Leishmaniasis Piper Bioactivity |
| topic |
Malaria Leishmaniasis Piper Bioactivity |
| description |
Faculdade de Educação e Cultura de Vilhena. Departamento de Biomedicina. Vilhena, RO, Brasil. |
| publishDate |
2018 |
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2018 |
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2019-08-23T20:41:30Z |
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2019-08-23T20:41:30Z |
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OLIVEIRA, Flávio Augusto de Souza et al. Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits, Revista da Sociedade Brasileira de Medicina Tropical, v. 51, p. 382-386, 2018. |
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https://www.arca.fiocruz.br/handle/icict/35051 |
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0037-8682 |
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10.1590/0037-8682-0309-2017 |
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1678-9849 |
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OLIVEIRA, Flávio Augusto de Souza et al. Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits, Revista da Sociedade Brasileira de Medicina Tropical, v. 51, p. 382-386, 2018. 0037-8682 10.1590/0037-8682-0309-2017 1678-9849 |
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