Lipid droplets: platforms with multiple functions in cancer hallmarks

Detalhes bibliográficos
Autor(a) principal: Cruz, André L. S.
Data de Publicação: 2020
Outros Autores: Barreto, Ester de A., Fazolini, Narayana P. B., Viola, João P. B., Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40878
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Polo Novo Cavaleiros. Laboratório de Fisiopatologia. Macaé, RJ, Brasil.
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spelling Cruz, André L. S.Barreto, Ester de A.Fazolini, Narayana P. B.Viola, João P. B.Bozza, Patrícia T.2020-04-19T18:47:59Z2020-04-19T18:47:59Z2020CRUZ, André L. S. et al. Lipid droplets: platforms with multiple functions in cancer hallmarks. Cell Death & Disease, v. 11, n. 105, p. 1-16, 2020.2041-4889https://www.arca.fiocruz.br/handle/icict/4087810.1038/s41419-020-2297-3engSpringer NatureGotículas lipídicasPlataformas com múltiplas funçõeMarcadores de CâncerLipid dropletsCancer hallmarksPlatforms with multiple functionsLipid droplets: platforms with multiple functions in cancer hallmarksinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Polo Novo Cavaleiros. Laboratório de Fisiopatologia. Macaé, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Programa de Imunologia e Biologia Tumoral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40878/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaTBozza_EsterBarreto_etal_IOC_2020.pdfPatriciaTBozza_EsterBarreto_etal_IOC_2020.pdfapplication/pdf1473240https://www.arca.fiocruz.br/bitstream/icict/40878/2/PatriciaTBozza_EsterBarreto_etal_IOC_2020.pdffa5e8af92ba466dc976d7e709a23ae44MD52TEXTPatriciaTBozza_EsterBarreto_etal_IOC_2020.pdf.txtPatriciaTBozza_EsterBarreto_etal_IOC_2020.pdf.txtExtracted texttext/plain89479https://www.arca.fiocruz.br/bitstream/icict/40878/3/PatriciaTBozza_EsterBarreto_etal_IOC_2020.pdf.txt7fcb821f95ad99da2a68f77028dad44aMD53icict/408782022-06-24 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dc.title.pt_BR.fl_str_mv Lipid droplets: platforms with multiple functions in cancer hallmarks
title Lipid droplets: platforms with multiple functions in cancer hallmarks
spellingShingle Lipid droplets: platforms with multiple functions in cancer hallmarks
Cruz, André L. S.
Gotículas lipídicas
Plataformas com múltiplas funçõe
Marcadores de Câncer
Lipid droplets
Cancer hallmarks
Platforms with multiple functions
title_short Lipid droplets: platforms with multiple functions in cancer hallmarks
title_full Lipid droplets: platforms with multiple functions in cancer hallmarks
title_fullStr Lipid droplets: platforms with multiple functions in cancer hallmarks
title_full_unstemmed Lipid droplets: platforms with multiple functions in cancer hallmarks
title_sort Lipid droplets: platforms with multiple functions in cancer hallmarks
author Cruz, André L. S.
author_facet Cruz, André L. S.
Barreto, Ester de A.
Fazolini, Narayana P. B.
Viola, João P. B.
Bozza, Patrícia T.
author_role author
author2 Barreto, Ester de A.
Fazolini, Narayana P. B.
Viola, João P. B.
Bozza, Patrícia T.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cruz, André L. S.
Barreto, Ester de A.
Fazolini, Narayana P. B.
Viola, João P. B.
Bozza, Patrícia T.
dc.subject.other.pt_BR.fl_str_mv Gotículas lipídicas
Plataformas com múltiplas funçõe
Marcadores de Câncer
topic Gotículas lipídicas
Plataformas com múltiplas funçõe
Marcadores de Câncer
Lipid droplets
Cancer hallmarks
Platforms with multiple functions
dc.subject.en.pt_BR.fl_str_mv Lipid droplets
Cancer hallmarks
Platforms with multiple functions
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Polo Novo Cavaleiros. Laboratório de Fisiopatologia. Macaé, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-04-19T18:47:59Z
dc.date.available.fl_str_mv 2020-04-19T18:47:59Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, André L. S. et al. Lipid droplets: platforms with multiple functions in cancer hallmarks. Cell Death & Disease, v. 11, n. 105, p. 1-16, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40878
dc.identifier.issn.pt_BR.fl_str_mv 2041-4889
dc.identifier.doi.none.fl_str_mv 10.1038/s41419-020-2297-3
identifier_str_mv CRUZ, André L. S. et al. Lipid droplets: platforms with multiple functions in cancer hallmarks. Cell Death & Disease, v. 11, n. 105, p. 1-16, 2020.
2041-4889
10.1038/s41419-020-2297-3
url https://www.arca.fiocruz.br/handle/icict/40878
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40878/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40878/2/PatriciaTBozza_EsterBarreto_etal_IOC_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/40878/3/PatriciaTBozza_EsterBarreto_etal_IOC_2020.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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