Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56145 |
Resumo: | Oswaldo Cruz Foundation and Secretariat of Health Surveillance. Brazilian Ministry of Health. the National Institutes of Health of the United States. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Medical Research UK. |
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Eyre, Max T.Souza, Fábio N.Pereira, Ticiana SA CarvalhoNery, NivisonOliveira, Daiana deCruz, Jaqueline S.Sacramento, Gielson A.Khalil, HusseinWunder, Elsio A.Hacker, Kathryn P.Hagan, José E.Childs, James E.Reis, Mitermayer G.Begon, MikeDiggle, Peter J.Ko, Albert I.Giorgi, EmanueleCosta, Federico2022-12-21T19:10:02Z2022-12-21T19:10:02Z2022EYRE, Max T. et al. Linking rattiness, geography and environmental degradation to spillover leptospira infections in marginalized urban settings: an eco-epidemiological community-based cohort study in Brazil. eLife, v. 11, p. 1-34, 2022.2050-084Xhttps://www.arca.fiocruz.br/handle/icict/5614510.7554/eLife.73120Oswaldo Cruz Foundation and Secretariat of Health Surveillance. Brazilian Ministry of Health. the National Institutes of Health of the United States. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Medical Research UK.Centre for Health Informatics, Computing, and Statistics. Lancaster University Medical School. Lancaster, United Kingdom / Liverpool School of Tropical Medicine. Liverpool, United Kingdom.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Swedish University of Agricultural Sciences. Umeå, Sweden.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven United States.University of Pennsylvania. Philadelphia, United States.World Health Organization. Regional Office for Europe. Copenhagen, Denmark.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven United States.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil.Department of Evolution, Ecology and Behaviour. University of Liverpool. Liverpool, United Kingdom.Centre for Health Informatics, Computing, and Statistics. Lancaster University Medical School. Lancaster, United Kingdom.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven United States.Centre for Health Informatics, Computing, and Statistics. Lancaster University Medical School. Lancaster, United Kingdom.Centre for Health Informatics, Computing, and Statistics. Lancaster University Medical School. Lancaster, United Kingdom / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven United States.Background: Zoonotic spillover from animal reservoirs is responsible for a significant global public health burden, but the processes that promote spillover events are poorly understood in complex urban settings. Endemic transmission of Leptospira, the agent of leptospirosis, in marginalised urban communities occurs through human exposure to an environment contaminated by bacteria shed in the urine of the rat reservoir. However, it is unclear to what extent transmission is driven by variation in the distribution of rats or by the dispersal of bacteria in rainwater runoff and overflow from open sewer systems. Methods: We conducted an eco-epidemiological study in a high-risk community in Salvador, Brazil, by prospectively following a cohort of 1401 residents to ascertain serological evidence for leptospiral infections. A concurrent rat ecology study was used to collect information on the fine-scale spatial distribution of ‘rattiness’, our proxy for rat abundance and exposure of interest. We developed and applied a novel geostatistical framework for joint spatial modelling of multiple indices of disease reservoir abundance and human infection risk. Results: The estimated infection rate was 51.4 (95%CI 40.4, 64.2) infections per 1000 follow-up events. Infection risk increased with age until 30 years of age and was associated with male gender. Rattiness was positively associated with infection risk for residents across the entire study area, but this effect was stronger in higher elevation areas (OR 3.27 95% CI 1.68, 19.07) than in lower elevation areas (OR 1.14 95% CI 1.05, 1.53). Conclusions: These findings suggest that, while frequent flooding events may disperse bacteria in regions of low elevation, environmental risk in higher elevation areas is more localised and directly driven by the distribution of local rat populations. The modelling framework developed may have broad applications in delineating complex animal-environment-human interactions during zoonotic spillover and identifying opportunities for public health intervention.engeLife Sciences PublicationsLeptospiraInfecçõesDegradação ambientalComunidade urbanaBrasilLeptospirainfectionsInfectionsEnvironmental degradationUrban communityBrazilLeptospiraInfecçõesComunidade dos Países de Língua PortuguesaBrazilLinking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56145/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEyre, Max T - Linking rattiness, geography and.pdfEyre, Max T - Linking rattiness, geography and.pdfapplication/pdf4083770https://www.arca.fiocruz.br/bitstream/icict/56145/2/Eyre%2c%20Max%20T%20-%20Linking%20rattiness%2c%20geography%20and.pdf212f73294e328b7365e6fbd05dc5b8f3MD52icict/561452023-03-15 14:32:49.472oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:49Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.en_US.fl_str_mv |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| title |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| spellingShingle |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil Eyre, Max T. Leptospira Infecções Degradação ambiental Comunidade urbana Brasil Leptospira infections Infections Environmental degradation Urban community Brazil Leptospira Infecções Comunidade dos Países de Língua Portuguesa Brazil |
| title_short |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| title_full |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| title_fullStr |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| title_full_unstemmed |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| title_sort |
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil |
| author |
Eyre, Max T. |
| author_facet |
Eyre, Max T. Souza, Fábio N. Pereira, Ticiana SA Carvalho Nery, Nivison Oliveira, Daiana de Cruz, Jaqueline S. Sacramento, Gielson A. Khalil, Hussein Wunder, Elsio A. Hacker, Kathryn P. Hagan, José E. Childs, James E. Reis, Mitermayer G. Begon, Mike Diggle, Peter J. Ko, Albert I. Giorgi, Emanuele Costa, Federico |
| author_role |
author |
| author2 |
Souza, Fábio N. Pereira, Ticiana SA Carvalho Nery, Nivison Oliveira, Daiana de Cruz, Jaqueline S. Sacramento, Gielson A. Khalil, Hussein Wunder, Elsio A. Hacker, Kathryn P. Hagan, José E. Childs, James E. Reis, Mitermayer G. Begon, Mike Diggle, Peter J. Ko, Albert I. Giorgi, Emanuele Costa, Federico |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Eyre, Max T. Souza, Fábio N. Pereira, Ticiana SA Carvalho Nery, Nivison Oliveira, Daiana de Cruz, Jaqueline S. Sacramento, Gielson A. Khalil, Hussein Wunder, Elsio A. Hacker, Kathryn P. Hagan, José E. Childs, James E. Reis, Mitermayer G. Begon, Mike Diggle, Peter J. Ko, Albert I. Giorgi, Emanuele Costa, Federico |
| dc.subject.other.en_US.fl_str_mv |
Leptospira Infecções Degradação ambiental Comunidade urbana Brasil |
| topic |
Leptospira Infecções Degradação ambiental Comunidade urbana Brasil Leptospira infections Infections Environmental degradation Urban community Brazil Leptospira Infecções Comunidade dos Países de Língua Portuguesa Brazil |
| dc.subject.en.en_US.fl_str_mv |
Leptospira infections Infections Environmental degradation Urban community Brazil |
| dc.subject.decs.en_US.fl_str_mv |
Leptospira Infecções Comunidade dos Países de Língua Portuguesa Brazil |
| description |
Oswaldo Cruz Foundation and Secretariat of Health Surveillance. Brazilian Ministry of Health. the National Institutes of Health of the United States. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Medical Research UK. |
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2022 |
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2022-12-21T19:10:02Z |
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2022-12-21T19:10:02Z |
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2022 |
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EYRE, Max T. et al. Linking rattiness, geography and environmental degradation to spillover leptospira infections in marginalized urban settings: an eco-epidemiological community-based cohort study in Brazil. eLife, v. 11, p. 1-34, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56145 |
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2050-084X |
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10.7554/eLife.73120 |
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EYRE, Max T. et al. Linking rattiness, geography and environmental degradation to spillover leptospira infections in marginalized urban settings: an eco-epidemiological community-based cohort study in Brazil. eLife, v. 11, p. 1-34, 2022. 2050-084X 10.7554/eLife.73120 |
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eLife Sciences Publications |
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eLife Sciences Publications |
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