Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48987 |
Resumo: | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Nova Universidade de Lisboa. Instituto de Higiene e Medicina Tropical. Saúde Global e Medicina Tropical. Lisboa, Portugal. |
| id |
CRUZ_92cbc4ee49e77e3b04c1a94b541a3c7a |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/48987 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Ferreira, Marcelo U.Sousa, Tais Nobrega deRangel, Gabriel W.Johansen, Igor C.Corder, Rodrigo M.Ladeia-Andrade, SimoneGil, José Pedro2021-09-05T14:23:18Z2021-09-05T14:23:18Z2021FERREIRA, Marcelo U. et al. Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions. International Journal for Parasitology: Drugs and Drug Resistance, v. 15, p. 9- 24, 2021.2211-3207https://www.arca.fiocruz.br/handle/icict/4898710.1016/j.ijpddr.2020.12.001engElsevierPlasmodium vivaxResistência às drogasCloroquinaPrimaquinaEstudos clínicosEnsaios ex vivoMarcadores molecularesPlasmodium vivaxDrug resistanceChloroquinePrimaquineClinical studiesEx vivo assaysMolecular markersMonitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Nova Universidade de Lisboa. Instituto de Higiene e Medicina Tropical. Saúde Global e Medicina Tropical. Lisboa, Portugal.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Department of Biochemistry and Molecular Biology, Pennsylvania State University. University Park, PA, USA.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Department of Microbiology, Tumor and Cell Biology, Karolinska Institute. Solna, Sweden.Emerging antimalarial drug resistance may undermine current efforts to control and eliminate Plasmodium vivax, the most geographically widespread yet neglected human malaria parasite. Endemic countries are expected to assess regularly the therapeutic efficacy of antimalarial drugs in use in order to adjust their malaria treatment policies, but proper funding and trained human resources are often lacking to execute relatively complex and expensive clinical studies, ideally complemented by ex vivo assays of drug resistance. Here we review the challenges for assessing in vivo P. vivax responses to commonly used antimalarials, especially chloroquine and primaquine, in the presence of confounding factors such as variable drug absorption, metabolism and interaction, and the risk of new infections following successful radical cure. We introduce a simple modeling approach to quantify the relative contribution of relapses and new infections to recurring parasitemias in clinical studies of hypnozoitocides. Finally, we examine recent methodological advances that may render ex vivo assays more practical and widely used to confirm P. vivax drug resistance phenotypes in endemic settings and review current approaches to the development of robust genetic markers for monitoring chloroquine resistance in P. vivax populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48987/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSimoneL_Andrade2_etal_IOC_2021.pdfSimoneL_Andrade2_etal_IOC_2021.pdfapplication/pdf5683869https://www.arca.fiocruz.br/bitstream/icict/48987/2/SimoneL_Andrade2_etal_IOC_2021.pdfe3e1d4e0a7155767f9b2723f00dd37baMD52TEXTSimoneL_Andrade2_etal_IOC_2021.pdf.txtSimoneL_Andrade2_etal_IOC_2021.pdf.txtExtracted texttext/plain131525https://www.arca.fiocruz.br/bitstream/icict/48987/3/SimoneL_Andrade2_etal_IOC_2021.pdf.txt1889e49408940d0bf6cff9c8ce4a589eMD53icict/489872021-09-06 02:01:11.236oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-09-06T05:01:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| title |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| spellingShingle |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions Ferreira, Marcelo U. Plasmodium vivax Resistência às drogas Cloroquina Primaquina Estudos clínicos Ensaios ex vivo Marcadores moleculares Plasmodium vivax Drug resistance Chloroquine Primaquine Clinical studies Ex vivo assays Molecular markers |
| title_short |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| title_full |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| title_fullStr |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| title_full_unstemmed |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| title_sort |
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions |
| author |
Ferreira, Marcelo U. |
| author_facet |
Ferreira, Marcelo U. Sousa, Tais Nobrega de Rangel, Gabriel W. Johansen, Igor C. Corder, Rodrigo M. Ladeia-Andrade, Simone Gil, José Pedro |
| author_role |
author |
| author2 |
Sousa, Tais Nobrega de Rangel, Gabriel W. Johansen, Igor C. Corder, Rodrigo M. Ladeia-Andrade, Simone Gil, José Pedro |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferreira, Marcelo U. Sousa, Tais Nobrega de Rangel, Gabriel W. Johansen, Igor C. Corder, Rodrigo M. Ladeia-Andrade, Simone Gil, José Pedro |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium vivax Resistência às drogas Cloroquina Primaquina Estudos clínicos Ensaios ex vivo Marcadores moleculares |
| topic |
Plasmodium vivax Resistência às drogas Cloroquina Primaquina Estudos clínicos Ensaios ex vivo Marcadores moleculares Plasmodium vivax Drug resistance Chloroquine Primaquine Clinical studies Ex vivo assays Molecular markers |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Drug resistance Chloroquine Primaquine Clinical studies Ex vivo assays Molecular markers |
| description |
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Nova Universidade de Lisboa. Instituto de Higiene e Medicina Tropical. Saúde Global e Medicina Tropical. Lisboa, Portugal. |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-09-05T14:23:18Z |
| dc.date.available.fl_str_mv |
2021-09-05T14:23:18Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
FERREIRA, Marcelo U. et al. Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions. International Journal for Parasitology: Drugs and Drug Resistance, v. 15, p. 9- 24, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48987 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2211-3207 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.ijpddr.2020.12.001 |
| identifier_str_mv |
FERREIRA, Marcelo U. et al. Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions. International Journal for Parasitology: Drugs and Drug Resistance, v. 15, p. 9- 24, 2021. 2211-3207 10.1016/j.ijpddr.2020.12.001 |
| url |
https://www.arca.fiocruz.br/handle/icict/48987 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/48987/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/48987/2/SimoneL_Andrade2_etal_IOC_2021.pdf https://www.arca.fiocruz.br/bitstream/icict/48987/3/SimoneL_Andrade2_etal_IOC_2021.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 e3e1d4e0a7155767f9b2723f00dd37ba 1889e49408940d0bf6cff9c8ce4a589e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324902295502848 |