Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique

Detalhes bibliográficos
Autor(a) principal: Chvale, Helena
Data de Publicação: 2012
Outros Autores: Oliveira, Joanna Reis Santos, Cruz, Alda Maria da, Enosse, Sonia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18857
Resumo: Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.
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spelling Chvale, HelenaOliveira, Joanna Reis SantosCruz, Alda Maria daEnosse, Sonia2017-05-16T12:19:41Z2017-05-16T12:19:41Z2012CHAVALE, Helena; et al. Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. Mem Inst Oswaldo Cruz, v.107, n.8, p.985-992, Dec.2012.0074-0276https://www.arca.fiocruz.br/handle/icict/188571678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzMaláriaHIVAIDSAtivação celularPlasmodiumMoçambiquemalaria/HIV-AIDScellular activationPlasmodiumco-infectionCD4+ T cellsMozambiqueEnhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambiqueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.Human immunodeficiency virus (HIV)-1 infection has an important impact on malaria. Plasmodium falciparum and HIV-1 co-infected patients (Pf/HIV) present with a high degree of anaemia, enhanced parasitaemia and decreased CD4+ T cell counts, which increase the risk of developing severe malaria. In addition, infection with either Pf or HIV-1 alone causes extensive immune activation. Our hypothesis was that lymphocyte activation is potentiated in Pf/HIV co-infected patients, consequently worsening their immunosuppressed state. To test this hypothesis, 22 Pf/HIV patients, 34 malaria patients, 29 HIV/AIDS patients and 10 healthy controls without malaria or HIV/acquired immune deficiency syndrome (AIDS) from Maputo/Mozambique were recruited for this study. As expected, anaemia was most prevalent in the Pf/HIV group. A significant variation in parasite density was observed in the Pf/HIV co-infected group (110-75,000 parasites/μL), although the median values were similar to those of the malaria only patients. The CD4+ T cell counts were significantly lower in the Pf/HIV group than in the HIV/AIDS only or malaria only patients. Lymphocyte activation was evaluated by the percentage of activation-associated molecules [CD38 expression on CD8+ and human leukocyte antigen-DR expression on CD3+ T cells]. The highest CD38 expression was detected in the Pf/HIV co-infected patients (median = 78.2%). The malaria only (median = 50%) and HIV/AIDS only (median = 52%) patients also exhibited elevated levels of these molecules, although the values were lower than those of the Pf/HIV co-infected cases. Our findings suggest that enhanced T-cell activation in co-infected patients can worsen the immune response to both diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18857/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALaldamaria_cruz_etal_IOC_2012.pdfaldamaria_cruz_etal_IOC_2012.pdfapplication/pdf514990https://www.arca.fiocruz.br/bitstream/icict/18857/2/aldamaria_cruz_etal_IOC_2012.pdfd75080e86e19b97881700b18bec471d5MD52TEXTaldamaria_cruz_etal_IOC_2012.pdf.txtaldamaria_cruz_etal_IOC_2012.pdf.txtExtracted texttext/plain43369https://www.arca.fiocruz.br/bitstream/icict/18857/3/aldamaria_cruz_etal_IOC_2012.pdf.txtdcb5aada938de7afe0ab36669cd666c9MD53icict/188572018-08-15 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dc.title.pt_BR.fl_str_mv Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
title Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
spellingShingle Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
Chvale, Helena
Malária
HIV
AIDS
Ativação celular
Plasmodium
Moçambique
malaria/HIV-AIDS
cellular activation
Plasmodium
co-infection
CD4+ T cells
Mozambique
title_short Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
title_full Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
title_fullStr Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
title_full_unstemmed Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
title_sort Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique
author Chvale, Helena
author_facet Chvale, Helena
Oliveira, Joanna Reis Santos
Cruz, Alda Maria da
Enosse, Sonia
author_role author
author2 Oliveira, Joanna Reis Santos
Cruz, Alda Maria da
Enosse, Sonia
author2_role author
author
author
dc.contributor.author.fl_str_mv Chvale, Helena
Oliveira, Joanna Reis Santos
Cruz, Alda Maria da
Enosse, Sonia
dc.subject.other.pt_BR.fl_str_mv Malária
HIV
AIDS
Ativação celular
Plasmodium
Moçambique
topic Malária
HIV
AIDS
Ativação celular
Plasmodium
Moçambique
malaria/HIV-AIDS
cellular activation
Plasmodium
co-infection
CD4+ T cells
Mozambique
dc.subject.en.pt_BR.fl_str_mv malaria/HIV-AIDS
cellular activation
Plasmodium
co-infection
CD4+ T cells
Mozambique
description Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-05-16T12:19:41Z
dc.date.available.fl_str_mv 2017-05-16T12:19:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAVALE, Helena; et al. Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. Mem Inst Oswaldo Cruz, v.107, n.8, p.985-992, Dec.2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18857
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CHAVALE, Helena; et al. Enhanced T cell activation in Plasmodium falciparum malaria-infected human immunodeficiency virus-1 patients from Mozambique. Mem Inst Oswaldo Cruz, v.107, n.8, p.985-992, Dec.2012.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/18857
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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