Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15919 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Fabiane L. deAraujo-Jorge, Tania C.Souza, Elen M. deOliveira, Gabriel M. deDegrave, Wim M.Feige, Jean-JacquesBailly, SabineWaghabi, Mariana C.2016-09-22T17:19:04Z2016-09-22T17:19:04Z2012OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012.1935-2727https://www.arca.fiocruz.br/handle/icict/1591910.1371/journal.pntd.00016961935-2735engPublic Library of ScienceDoença de ChagasTrypanosoma cruziInibidoresGW788388Cardiomiopatia ChagásicaChagas diseaseTrypanosoma cruziCardiomyopathyGW788388InhibitorsGrowth Factor beta (TGFß)Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory steps of T. cruzi invasion and in host tissue fibrosis. GW788388 is a new TGFß type I and type II receptor kinase inhibitor that can be orally administered. In the present work, we studied its effects in vivo during the acute phase of experimental Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15919/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfabiane_oliveira_etal_IOC_2012.pdffabiane_oliveira_etal_IOC_2012.pdfapplication/pdf3934707https://www.arca.fiocruz.br/bitstream/icict/15919/2/fabiane_oliveira_etal_IOC_2012.pdf4855035d52c71d82f38233cd903d3861MD52TEXTfabiane_oliveira_etal_IOC_2012.pdf.txtfabiane_oliveira_etal_IOC_2012.pdf.txtExtracted texttext/plain59510https://www.arca.fiocruz.br/bitstream/icict/15919/3/fabiane_oliveira_etal_IOC_2012.pdf.txtfe1a49a82a0402e42ec96ddb5e7f540aMD53icict/159192022-06-24 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dc.title.pt_BR.fl_str_mv |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
title |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
spellingShingle |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease Oliveira, Fabiane L. de Doença de Chagas Trypanosoma cruzi Inibidores GW788388 Cardiomiopatia Chagásica Chagas disease Trypanosoma cruzi Cardiomyopathy GW788388 Inhibitors Growth Factor beta (TGFß) |
title_short |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
title_full |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
title_fullStr |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
title_full_unstemmed |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
title_sort |
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease |
author |
Oliveira, Fabiane L. de |
author_facet |
Oliveira, Fabiane L. de Araujo-Jorge, Tania C. Souza, Elen M. de Oliveira, Gabriel M. de Degrave, Wim M. Feige, Jean-Jacques Bailly, Sabine Waghabi, Mariana C. |
author_role |
author |
author2 |
Araujo-Jorge, Tania C. Souza, Elen M. de Oliveira, Gabriel M. de Degrave, Wim M. Feige, Jean-Jacques Bailly, Sabine Waghabi, Mariana C. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Fabiane L. de Araujo-Jorge, Tania C. Souza, Elen M. de Oliveira, Gabriel M. de Degrave, Wim M. Feige, Jean-Jacques Bailly, Sabine Waghabi, Mariana C. |
dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Inibidores GW788388 Cardiomiopatia Chagásica |
topic |
Doença de Chagas Trypanosoma cruzi Inibidores GW788388 Cardiomiopatia Chagásica Chagas disease Trypanosoma cruzi Cardiomyopathy GW788388 Inhibitors Growth Factor beta (TGFß) |
dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Trypanosoma cruzi Cardiomyopathy GW788388 Inhibitors Growth Factor beta (TGFß) |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2016-09-22T17:19:04Z |
dc.date.available.fl_str_mv |
2016-09-22T17:19:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15919 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0001696 |
dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
identifier_str_mv |
OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012. 1935-2727 10.1371/journal.pntd.0001696 1935-2735 |
url |
https://www.arca.fiocruz.br/handle/icict/15919 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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Repositório Institucional da FIOCRUZ (ARCA) |
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