Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome

Detalhes bibliográficos
Autor(a) principal: Macedo-da-Silva, Janaina
Data de Publicação: 2020
Outros Autores: Rosa-Fernandes, Lívia, Barbosa, Raquel Hora, Angeli, Claudia B., Carvalho, Fabiana Rabe, Vianna, Renata Artimos de Oliveira, Carvalho, Paulo Costa, Larsen, Martin R., Cardoso, Claudete Araújo, Palmisano, Giuseppe
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45647
Resumo: Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.
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spelling Macedo-da-Silva, JanainaRosa-Fernandes, LíviaBarbosa, Raquel HoraAngeli, Claudia B.Carvalho, Fabiana RabeVianna, Renata Artimos de OliveiraCarvalho, Paulo CostaLarsen, Martin R.Cardoso, Claudete AraújoPalmisano, Giuseppe2021-01-11T19:15:16Z2021-01-11T19:15:16Z2020MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4564710.3389/fcimb.2020.577819porFrontiers MediaBiomarcadoresSíndrome Congênita de ZikaZika VirusSerumProteomicsMass SpectrometryZika Virus InfectionVirus ZikaSueroProteómicaEspectrometría de MasasInfección por el Virus ZikaVirus ZikaSérumProtéomiqueSpectrométrie de masseInfection par le virus ZikaZika virusSoroProteômicaEspectrometria de MassasSerum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Department of Biochemistry and Molecular Biology. University of Southern Denmark. Odense, Denmark.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in infants who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows that 6% of infants exposed to ZIKV during pregnancy have complications present at birth, and this rate rises to 14% when medical monitoring is performed in all exposed infants, regardless of birth condition. Thus, the evaluation and monitoring of all exposed infants are of foremost importance as the development of late complications has been increasingly supported by clinical evidence. The identification of changes in protein profile of infants exposed to ZIKV without CZS could provide valuable findings to better understand molecular changes in this cohort. Here, we use a shotgun-proteomics approach to investigate alterations in the serum of infants without CZS symptoms but exposed to intrauterine ZIKV (ZIKV) compared to unexposed controls (CTRL). A complex pattern of differentially expressed proteins was identified, highlighting the dysregulation of proteins involved in axon orientation, visual phototransduction, and global protease activity in children exposed to ZIKV without CZS. These data support the importance of monitoring children exposed to ZIKV during gestation and without early CZS symptoms. Our study is the first to assess molecular evidence of possible late disorders in children victims of the ZIKV outbreak in the Americas. We emphasize the importance of medical monitoring of symptomatic and asymptomatic children, as apparently unexplained late neurological and eye disorders may be due to intrauterine ZIKV exposure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/45647/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfcimb-10-577819.pdffcimb-10-577819.pdfapplication/pdf2665886https://www.arca.fiocruz.br/bitstream/icict/45647/2/fcimb-10-577819.pdfe9cf57f5e9d1890837fb392c3619460aMD52TEXTfcimb-10-577819.pdf.txtfcimb-10-577819.pdf.txtExtracted texttext/plain71187https://www.arca.fiocruz.br/bitstream/icict/45647/3/fcimb-10-577819.pdf.txtcb87f0f60b86ea69e1d5f062ea4d4467MD53icict/456472021-01-12 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dc.title.pt_BR.fl_str_mv Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
title Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
spellingShingle Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
Macedo-da-Silva, Janaina
Biomarcadores
Síndrome Congênita de Zika
Zika Virus
Serum
Proteomics
Mass Spectrometry
Zika Virus Infection
Virus Zika
Suero
Proteómica
Espectrometría de Masas
Infección por el Virus Zika
Virus Zika
Sérum
Protéomique
Spectrométrie de masse
Infection par le virus Zika
Zika virus
Soro
Proteômica
Espectrometria de Massas
title_short Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
title_full Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
title_fullStr Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
title_full_unstemmed Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
title_sort Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
author Macedo-da-Silva, Janaina
author_facet Macedo-da-Silva, Janaina
Rosa-Fernandes, Lívia
Barbosa, Raquel Hora
Angeli, Claudia B.
Carvalho, Fabiana Rabe
Vianna, Renata Artimos de Oliveira
Carvalho, Paulo Costa
Larsen, Martin R.
Cardoso, Claudete Araújo
Palmisano, Giuseppe
author_role author
author2 Rosa-Fernandes, Lívia
Barbosa, Raquel Hora
Angeli, Claudia B.
Carvalho, Fabiana Rabe
Vianna, Renata Artimos de Oliveira
Carvalho, Paulo Costa
Larsen, Martin R.
Cardoso, Claudete Araújo
Palmisano, Giuseppe
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo-da-Silva, Janaina
Rosa-Fernandes, Lívia
Barbosa, Raquel Hora
Angeli, Claudia B.
Carvalho, Fabiana Rabe
Vianna, Renata Artimos de Oliveira
Carvalho, Paulo Costa
Larsen, Martin R.
Cardoso, Claudete Araújo
Palmisano, Giuseppe
dc.subject.other.pt_BR.fl_str_mv Biomarcadores
Síndrome Congênita de Zika
topic Biomarcadores
Síndrome Congênita de Zika
Zika Virus
Serum
Proteomics
Mass Spectrometry
Zika Virus Infection
Virus Zika
Suero
Proteómica
Espectrometría de Masas
Infección por el Virus Zika
Virus Zika
Sérum
Protéomique
Spectrométrie de masse
Infection par le virus Zika
Zika virus
Soro
Proteômica
Espectrometria de Massas
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Serum
Proteomics
Mass Spectrometry
Zika Virus Infection
dc.subject.es.pt_BR.fl_str_mv Virus Zika
Suero
Proteómica
Espectrometría de Masas
Infección por el Virus Zika
dc.subject.fr.pt_BR.fl_str_mv Virus Zika
Sérum
Protéomique
Spectrométrie de masse
Infection par le virus Zika
dc.subject.decs.pt_BR.fl_str_mv Zika virus
Soro
Proteômica
Espectrometria de Massas
description Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-11T19:15:16Z
dc.date.available.fl_str_mv 2021-01-11T19:15:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45647
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.577819
identifier_str_mv MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020.
2235-2988
10.3389/fcimb.2020.577819
url https://www.arca.fiocruz.br/handle/icict/45647
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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