Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45647 |
Resumo: | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. |
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Macedo-da-Silva, JanainaRosa-Fernandes, LíviaBarbosa, Raquel HoraAngeli, Claudia B.Carvalho, Fabiana RabeVianna, Renata Artimos de OliveiraCarvalho, Paulo CostaLarsen, Martin R.Cardoso, Claudete AraújoPalmisano, Giuseppe2021-01-11T19:15:16Z2021-01-11T19:15:16Z2020MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4564710.3389/fcimb.2020.577819porFrontiers MediaBiomarcadoresSíndrome Congênita de ZikaZika VirusSerumProteomicsMass SpectrometryZika Virus InfectionVirus ZikaSueroProteómicaEspectrometría de MasasInfección por el Virus ZikaVirus ZikaSérumProtéomiqueSpectrométrie de masseInfection par le virus ZikaZika virusSoroProteômicaEspectrometria de MassasSerum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Department of Biochemistry and Molecular Biology. University of Southern Denmark. Odense, Denmark.Universidade Federal Fluminense. Faculdade de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. / Universidade Federal Fluminense. Faculdade de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil.In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in infants who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIKV in the uterus have complications included in abnormalities related to Congenital Zika Syndrome (CZS). The risk of complications after birth is not well documented, however, clinical evidence shows that 6% of infants exposed to ZIKV during pregnancy have complications present at birth, and this rate rises to 14% when medical monitoring is performed in all exposed infants, regardless of birth condition. Thus, the evaluation and monitoring of all exposed infants are of foremost importance as the development of late complications has been increasingly supported by clinical evidence. The identification of changes in protein profile of infants exposed to ZIKV without CZS could provide valuable findings to better understand molecular changes in this cohort. Here, we use a shotgun-proteomics approach to investigate alterations in the serum of infants without CZS symptoms but exposed to intrauterine ZIKV (ZIKV) compared to unexposed controls (CTRL). A complex pattern of differentially expressed proteins was identified, highlighting the dysregulation of proteins involved in axon orientation, visual phototransduction, and global protease activity in children exposed to ZIKV without CZS. These data support the importance of monitoring children exposed to ZIKV during gestation and without early CZS symptoms. Our study is the first to assess molecular evidence of possible late disorders in children victims of the ZIKV outbreak in the Americas. We emphasize the importance of medical monitoring of symptomatic and asymptomatic children, as apparently unexplained late neurological and eye disorders may be due to intrauterine ZIKV exposure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/45647/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfcimb-10-577819.pdffcimb-10-577819.pdfapplication/pdf2665886https://www.arca.fiocruz.br/bitstream/icict/45647/2/fcimb-10-577819.pdfe9cf57f5e9d1890837fb392c3619460aMD52TEXTfcimb-10-577819.pdf.txtfcimb-10-577819.pdf.txtExtracted texttext/plain71187https://www.arca.fiocruz.br/bitstream/icict/45647/3/fcimb-10-577819.pdf.txtcb87f0f60b86ea69e1d5f062ea4d4467MD53icict/456472021-01-12 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dc.title.pt_BR.fl_str_mv |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
title |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
spellingShingle |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome Macedo-da-Silva, Janaina Biomarcadores Síndrome Congênita de Zika Zika Virus Serum Proteomics Mass Spectrometry Zika Virus Infection Virus Zika Suero Proteómica Espectrometría de Masas Infección por el Virus Zika Virus Zika Sérum Protéomique Spectrométrie de masse Infection par le virus Zika Zika virus Soro Proteômica Espectrometria de Massas |
title_short |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
title_full |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
title_fullStr |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
title_full_unstemmed |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
title_sort |
Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with in utero exposure to Zika Virus without congenital Zika Syndrome |
author |
Macedo-da-Silva, Janaina |
author_facet |
Macedo-da-Silva, Janaina Rosa-Fernandes, Lívia Barbosa, Raquel Hora Angeli, Claudia B. Carvalho, Fabiana Rabe Vianna, Renata Artimos de Oliveira Carvalho, Paulo Costa Larsen, Martin R. Cardoso, Claudete Araújo Palmisano, Giuseppe |
author_role |
author |
author2 |
Rosa-Fernandes, Lívia Barbosa, Raquel Hora Angeli, Claudia B. Carvalho, Fabiana Rabe Vianna, Renata Artimos de Oliveira Carvalho, Paulo Costa Larsen, Martin R. Cardoso, Claudete Araújo Palmisano, Giuseppe |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Macedo-da-Silva, Janaina Rosa-Fernandes, Lívia Barbosa, Raquel Hora Angeli, Claudia B. Carvalho, Fabiana Rabe Vianna, Renata Artimos de Oliveira Carvalho, Paulo Costa Larsen, Martin R. Cardoso, Claudete Araújo Palmisano, Giuseppe |
dc.subject.other.pt_BR.fl_str_mv |
Biomarcadores Síndrome Congênita de Zika |
topic |
Biomarcadores Síndrome Congênita de Zika Zika Virus Serum Proteomics Mass Spectrometry Zika Virus Infection Virus Zika Suero Proteómica Espectrometría de Masas Infección por el Virus Zika Virus Zika Sérum Protéomique Spectrométrie de masse Infection par le virus Zika Zika virus Soro Proteômica Espectrometria de Massas |
dc.subject.en.pt_BR.fl_str_mv |
Zika Virus Serum Proteomics Mass Spectrometry Zika Virus Infection |
dc.subject.es.pt_BR.fl_str_mv |
Virus Zika Suero Proteómica Espectrometría de Masas Infección por el Virus Zika |
dc.subject.fr.pt_BR.fl_str_mv |
Virus Zika Sérum Protéomique Spectrométrie de masse Infection par le virus Zika |
dc.subject.decs.pt_BR.fl_str_mv |
Zika virus Soro Proteômica Espectrometria de Massas |
description |
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de glicoproteína. São Paulo, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-01-11T19:15:16Z |
dc.date.available.fl_str_mv |
2021-01-11T19:15:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45647 |
dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2020.577819 |
identifier_str_mv |
MACEDO-DA-SILVA, Janaina et al. Serum proteomics reveals alterations in protease activity, axon guidance, and visual phototransduction pathways in infants with In utero exposure to Zika Virus without congenital Zika Syndrome. Frontiers in Cellular and Infection Microbiology, v.10, n. 577819, p. 1–16, 2020. 2235-2988 10.3389/fcimb.2020.577819 |
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https://www.arca.fiocruz.br/handle/icict/45647 |
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Frontiers Media |
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Frontiers Media |
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