IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children

Detalhes bibliográficos
Autor(a) principal: Useche, Yerly M.
Data de Publicação: 2021
Outros Autores: Ribeiro-Alves, Marcelo, Xavier-Carvalho, Caroline, Cardoso, Cynthia C., Kubelka, Claire F., Moraes, Milton O., Bedoya-Berrio, Gabriel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50475
Resumo: University of Antioquia. Biology Institute. Research Group on Molecular Genetics. Medellín, Colombia.
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spelling Useche, Yerly M.Ribeiro-Alves, MarceloXavier-Carvalho, CarolineCardoso, Cynthia C.Kubelka, Claire F.Moraes, Milton O.Bedoya-Berrio, Gabriel2021-12-17T13:46:27Z2021-12-17T13:46:27Z2021USECHE, Yerly M. et al. IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children. International Journal of Scientific Reports, v. 7, n. 11, p. 544-550, 2021.2454-2156https://www.arca.fiocruz.br/handle/icict/5047510.18203/issn.2454-2156.IntJSciRep20214103engMedip AcademyIL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Antioquia. Biology Institute. Research Group on Molecular Genetics. Medellín, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.University of Antioquia. Biology Institute. Research Group on Molecular Genetics. Medellín, Colombia.Several variants involved in the expression of proteins related to immunopathological mechanisms have been associated with dengue, but few specifically related to severe dengue. In addition, children are a group with a high incidence and mortality rate due to dengue. Several immunopathological processes developed specifically in children affected with severe dengue partially explain this risk condition. This case-control retrospective study aimed to examine the association of variants in CD209, NFKBIA, IL12B, and IL1B genes with severe dengue. These genes encode proteins involved in one of the main pathways of the immune response against dengue virus infection. The study population included affected children and householding controls from Brazil. Genotyping was performed with Real-Time TaqMan assays, and the association analysis was performed with conditional logistic regressions. We found the IL1B rs1143634 genotypes carrying the T allele to be associated with susceptibility to severe dengue in children. The lower circulating levels of IL-1β associated with carrying the T allele of the IL1B rs1143634 suggest a role of this cytokine in the impairment of the immune response and plasma leakage, and, consequently, in the development of severe dengue.SNPsSevere dengueIL1BAssociationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50475/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALIL1B_Marcelo_Alves_etal_INI_2021.pdfIL1B_Marcelo_Alves_etal_INI_2021.pdfapplication/pdf240081https://www.arca.fiocruz.br/bitstream/icict/50475/2/IL1B_Marcelo_Alves_etal_INI_2021.pdf6d22f67f19c4a7d8437d7f3449b9d42aMD52icict/504752021-12-21 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dc.title.pt_BR.fl_str_mv IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
title IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
spellingShingle IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
Useche, Yerly M.
SNPs
Severe dengue
IL1B
Association
title_short IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
title_full IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
title_fullStr IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
title_full_unstemmed IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
title_sort IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children
author Useche, Yerly M.
author_facet Useche, Yerly M.
Ribeiro-Alves, Marcelo
Xavier-Carvalho, Caroline
Cardoso, Cynthia C.
Kubelka, Claire F.
Moraes, Milton O.
Bedoya-Berrio, Gabriel
author_role author
author2 Ribeiro-Alves, Marcelo
Xavier-Carvalho, Caroline
Cardoso, Cynthia C.
Kubelka, Claire F.
Moraes, Milton O.
Bedoya-Berrio, Gabriel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Useche, Yerly M.
Ribeiro-Alves, Marcelo
Xavier-Carvalho, Caroline
Cardoso, Cynthia C.
Kubelka, Claire F.
Moraes, Milton O.
Bedoya-Berrio, Gabriel
dc.subject.en.pt_BR.fl_str_mv SNPs
Severe dengue
IL1B
Association
topic SNPs
Severe dengue
IL1B
Association
description University of Antioquia. Biology Institute. Research Group on Molecular Genetics. Medellín, Colombia.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-17T13:46:27Z
dc.date.available.fl_str_mv 2021-12-17T13:46:27Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv USECHE, Yerly M. et al. IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children. International Journal of Scientific Reports, v. 7, n. 11, p. 544-550, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50475
dc.identifier.issn.pt_BR.fl_str_mv 2454-2156
dc.identifier.doi.none.fl_str_mv 10.18203/issn.2454-2156.IntJSciRep20214103
identifier_str_mv USECHE, Yerly M. et al. IL1B rs1143634 (+3953) variant associated with severe dengue in Brazilian children. International Journal of Scientific Reports, v. 7, n. 11, p. 544-550, 2021.
2454-2156
10.18203/issn.2454-2156.IntJSciRep20214103
url https://www.arca.fiocruz.br/handle/icict/50475
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Medip Academy
publisher.none.fl_str_mv Medip Academy
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50475/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50475/2/IL1B_Marcelo_Alves_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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