Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Macedo, Gleicy Amorim
Data de Publicação: 2014
Outros Autores: Gonin, Michelle Luiza Cortez, Pone, Sheila Moura, Cruz, Oswaldo Gonçalves, Nobre, Flávio Fonseca, Brasil, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9394
Resumo: Universidade Federal do Rio de Janeiro. Laboratório de Engenharia em Sistemas de Saúde. Programa de Engenharia Bioméica. Rio de Janeiro, RJ, Brasil.
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spelling Macedo, Gleicy AmorimGonin, Michelle Luiza CortezPone, Sheila MouraCruz, Oswaldo GonçalvesNobre, Flávio FonsecaBrasil, Patrícia2015-01-16T11:54:10Z2015-01-16T11:54:10Z2014MACEDO, Gleicy A et al. Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro. PLoS ONE, Rio de Janeiro, v. 9, n. 4, p. 1-9, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/9394engPublic Library of ScienceSensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Laboratório de Engenharia em Sistemas de Saúde. Programa de Engenharia Bioméica. Rio de Janeiro, RJ, Brasil.Hospital Municipal Jesus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Engenharia em Sistemas de Saúde. Programa de Engenharia Bioméica. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background:The clinical definition of severe dengue fever remains a challenge for researchers in hyperendemic areas like Brazil. The ability of the traditional (1997) as well as the revised (2009) World Health Organization (WHO) dengue case classification schemes to detect severe dengue cases was evaluated in 267 children admitted to hospital with laboratory-confirmed dengue. Principal Findings:Using the traditional scheme, 28.5% of patients could not be assigned to any category, while the revised scheme categorized all patients. Intensive therapeutic interventions were used as the reference standard to evaluate the ability of both the traditional and revised schemes to detect severe dengue cases. Analyses of the classified cases (n = 183) demonstrated that the revised scheme had better sensitivity (86.8%,P,0.001), while the traditional scheme had better specificity (93.4%,P,0.001) for the detection of severe forms of dengue. Conclusions/Significance:This improved sensitivity of the revised scheme allows for better case capture and increased ICU admission, which may aid pediatricians in avoiding deaths due to severe dengue among children, but, in turn, it may also result in the misclassification of the patients’ condition as severe, reflected in the observed lower positive predictive value (61.6%, P,0.001) when compared with the traditional scheme (82.6%, P,0.001). The inclusion of unusual dengue manifestations in the revised scheme has not shifted the emphasis from the most important aspects of dengue disease and the major factors contributing to fatality in this study: shock with consequent organ dysfunction.Severe DengueDengue Classification Schemeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9394/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALSensitivity and Specificity of the World Health Organization Dengue Classification Schemes for Severe Dengue Assessment in Children in Rio de Janeiro.pdfSensitivity and Specificity of the World Health Organization Dengue Classification Schemes for Severe Dengue Assessment in Children in Rio de Janeiro.pdfapplication/pdf260178https://www.arca.fiocruz.br/bitstream/icict/9394/2/Sensitivity%20and%20Specificity%20of%20the%20World%20Health%20Organization%20Dengue%20Classification%20Schemes%20for%20Severe%20Dengue%20Assessment%20in%20Children%20in%20Rio%20de%20Janeiro.pdfef8e3c9486fd16a631db047e74f16ee4MD52TEXTSensitivity and Specificity of the World Health Organization Dengue Classification Schemes for Severe Dengue Assessment in Children in Rio de Janeiro.pdf.txtSensitivity and Specificity of the World Health Organization Dengue Classification Schemes for Severe Dengue Assessment in Children in Rio de Janeiro.pdf.txtExtracted texttext/plain37867https://www.arca.fiocruz.br/bitstream/icict/9394/3/Sensitivity%20and%20Specificity%20of%20the%20World%20Health%20Organization%20Dengue%20Classification%20Schemes%20for%20Severe%20Dengue%20Assessment%20in%20Children%20in%20Rio%20de%20Janeiro.pdf.txt199d276cdaa21263c611928e1211e852MD53icict/93942018-04-04 07:58:10.8oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-04T10:58:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
title Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
spellingShingle Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
Macedo, Gleicy Amorim
Severe Dengue
Dengue Classification Scheme
title_short Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
title_full Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
title_fullStr Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
title_full_unstemmed Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
title_sort Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro
author Macedo, Gleicy Amorim
author_facet Macedo, Gleicy Amorim
Gonin, Michelle Luiza Cortez
Pone, Sheila Moura
Cruz, Oswaldo Gonçalves
Nobre, Flávio Fonseca
Brasil, Patrícia
author_role author
author2 Gonin, Michelle Luiza Cortez
Pone, Sheila Moura
Cruz, Oswaldo Gonçalves
Nobre, Flávio Fonseca
Brasil, Patrícia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo, Gleicy Amorim
Gonin, Michelle Luiza Cortez
Pone, Sheila Moura
Cruz, Oswaldo Gonçalves
Nobre, Flávio Fonseca
Brasil, Patrícia
dc.subject.en.pt_BR.fl_str_mv Severe Dengue
Dengue Classification Scheme
topic Severe Dengue
Dengue Classification Scheme
description Universidade Federal do Rio de Janeiro. Laboratório de Engenharia em Sistemas de Saúde. Programa de Engenharia Bioméica. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-01-16T11:54:10Z
dc.date.available.fl_str_mv 2015-01-16T11:54:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO, Gleicy A et al. Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro. PLoS ONE, Rio de Janeiro, v. 9, n. 4, p. 1-9, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9394
dc.identifier.issn.none.fl_str_mv 1932-6203
identifier_str_mv MACEDO, Gleicy A et al. Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro. PLoS ONE, Rio de Janeiro, v. 9, n. 4, p. 1-9, 2014.
1932-6203
url https://www.arca.fiocruz.br/handle/icict/9394
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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