Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3813 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil |
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Mello, Marco Antônio GomesMascarenhas, Rita Elizabeth MoreiraFerraro, Geraldo ArgoloHarn Junior, Donald ACastro Filho, Bernardo GalvãoBou-Habib, Dumith Chequer2012-03-23T21:31:30Z2012-03-23T21:31:30Z2005MELLO, M.A. et al. Cinhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. Medical Microbiology Immunology, v. 194, n.1-2, p. 61-5, jan. 2005.0300-8584https://www.arca.fiocruz.br/handle/icict/3813engInhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilHarvard School of Public Health. Boston, Massachusetts, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Patients infected with HIV-1 develop a potent humoral immune response against the virus, but HIV-1 primary isolates are remarkably resistant to neutralizing antibodies. Considering that the envelope glycoprotein of HIV-1 (gp120/41) is heavily glycosylated, we investigated whether anti-carbohydrate antibodies could inhibit HIV-1 infection in vitro. We studied the neutralizing activity of three monoclonal antibodies (mAbs) raised to carbohydrates of Schistosoma mansoni, against seven primary isolates of HIV-1. Assays were performed infecting peripheral blood mononuclear cells from normal donors with viral isolates previously treated with mAbs. Viral strains used were tropic for the coreceptors CCR5, CXCR4, and dual-tropic ones. We found that the anti-glycan mAbs vigorously inhibited HIV-1 infection, regardless of the preferential coreceptor usage of the isolate, in a dose-response manner. Importantly, five isolates were resistant to neutralization by two HIV-1 antibody-positive human sera endowed with potent anti-HIV-1 inhibitory activity. Our findings suggest that carbohydrates of the HIV-1 viral envelope may be a target of an effective humoral immune response elicited by vaccination.HIV-1AidsNeutralizingAntibodiesAnticorpos Anti-HelmínticosAnticorpos MonoclonaisCarboidratosInfecções por HIVSchistosoma mansoniAntígenos de HelmintosInfecções por HIVHIVTestes de NeutralizaçãoAnimaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMello MA Inhibition of HIV-1 infection....pdfMello MA Inhibition of HIV-1 infection....pdfapplication/pdf237058https://www.arca.fiocruz.br/bitstream/icict/3813/1/Mello%20MA%20Inhibition%20of%20HIV-1%20infection....pdf92429b3474e9a8ce109b3ed427938bc3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3813/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTMello MA Inhibition of HIV-1 infection....pdf.txtMello MA Inhibition of HIV-1 infection....pdf.txtExtracted texttext/plain27260https://www.arca.fiocruz.br/bitstream/icict/3813/5/Mello%20MA%20Inhibition%20of%20HIV-1%20infection....pdf.txt676735edb3bd25a7f50fcbc120119318MD55THUMBNAILMello MA Inhibition of HIV-1 infection....pdf.jpgMello MA Inhibition of HIV-1 infection....pdf.jpgGenerated Thumbnailimage/jpeg2358https://www.arca.fiocruz.br/bitstream/icict/3813/4/Mello%20MA%20Inhibition%20of%20HIV-1%20infection....pdf.jpg35c6ab0a37ce456913749fa6971e5042MD54icict/38132023-09-14 15:46:55.108oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:46:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| title |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| spellingShingle |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. Mello, Marco Antônio Gomes HIV-1 Aids Neutralizing Antibodies Anticorpos Anti-Helmínticos Anticorpos Monoclonais Carboidratos Infecções por HIV Schistosoma mansoni Antígenos de Helmintos Infecções por HIV HIV Testes de Neutralização Animais |
| title_short |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| title_full |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| title_fullStr |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| title_full_unstemmed |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| title_sort |
Inhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. |
| author |
Mello, Marco Antônio Gomes |
| author_facet |
Mello, Marco Antônio Gomes Mascarenhas, Rita Elizabeth Moreira Ferraro, Geraldo Argolo Harn Junior, Donald A Castro Filho, Bernardo Galvão Bou-Habib, Dumith Chequer |
| author_role |
author |
| author2 |
Mascarenhas, Rita Elizabeth Moreira Ferraro, Geraldo Argolo Harn Junior, Donald A Castro Filho, Bernardo Galvão Bou-Habib, Dumith Chequer |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Mello, Marco Antônio Gomes Mascarenhas, Rita Elizabeth Moreira Ferraro, Geraldo Argolo Harn Junior, Donald A Castro Filho, Bernardo Galvão Bou-Habib, Dumith Chequer |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Aids Neutralizing Antibodies |
| topic |
HIV-1 Aids Neutralizing Antibodies Anticorpos Anti-Helmínticos Anticorpos Monoclonais Carboidratos Infecções por HIV Schistosoma mansoni Antígenos de Helmintos Infecções por HIV HIV Testes de Neutralização Animais |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Anti-Helmínticos Anticorpos Monoclonais Carboidratos Infecções por HIV Schistosoma mansoni Antígenos de Helmintos Infecções por HIV HIV Testes de Neutralização Animais |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil |
| publishDate |
2005 |
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2005 |
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2012-03-23T21:31:30Z |
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2012-03-23T21:31:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MELLO, M.A. et al. Cinhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. Medical Microbiology Immunology, v. 194, n.1-2, p. 61-5, jan. 2005. |
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https://www.arca.fiocruz.br/handle/icict/3813 |
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0300-8584 |
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MELLO, M.A. et al. Cinhibition of HIV-1 infection by monoclonal antibodies to carbohydrates of Schistosoma mansoni. Medical Microbiology Immunology, v. 194, n.1-2, p. 61-5, jan. 2005. 0300-8584 |
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