Prenatal exposure to misoprostol and vascular disruption defects: a case-control study
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/210 |
Resumo: | Prenatal exposure to misoprostol has beenassociated with Moebius and limb defects.Vascular disruption has been proposed asthe mechanism for these teratogenic effects. The present study is a multicenter, casecontrol study that was designed to compare the frequency of prenatal misoprostol use between mothers of Brazilian children diagnosedwith vascular disruption defects andmatched control mothers of children diagnosed with other types of defects. A total of 93 cases and 279 controls were recruited in eight participating centers. Prenatal exposure was identified in 32 infants diagnosed with vascular disruption defects (34.4 percent) compared with only 12 (4.3 percent) in the control group (P menor que 0.0000001). Our data suggest thatprenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns. |
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Vargas, F. R.Schuler-Faccini, L.Brunoni, D.Kim, C.Meloni, V. F. A.Sugayama, S. M. M.Albano, L.Llerena Junior, Juan ClintonAlmeida, J. C. C.Duarte, A.Cavalcanti, D. P.Goloni-Bertollo, E.Conte, A.Koren, G.Addis, A.2010-08-23T16:00:16Z2010-08-23T16:00:16Z2000VARGAS, F. R. et al. Prenatal exposure to misoprostol and vascular disruption defects: a case-control study. Am. J. Med. Genet., New York, v. 95, n. 4, p. 302-306, dec. 2000.0148-7299https://www.arca.fiocruz.br/handle/icict/210Prenatal exposure to misoprostol has beenassociated with Moebius and limb defects.Vascular disruption has been proposed asthe mechanism for these teratogenic effects. The present study is a multicenter, casecontrol study that was designed to compare the frequency of prenatal misoprostol use between mothers of Brazilian children diagnosedwith vascular disruption defects andmatched control mothers of children diagnosed with other types of defects. A total of 93 cases and 279 controls were recruited in eight participating centers. Prenatal exposure was identified in 32 infants diagnosed with vascular disruption defects (34.4 percent) compared with only 12 (4.3 percent) in the control group (P menor que 0.0000001). Our data suggest thatprenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée-Guinle. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brasil.Hospital São Paulo. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Instituto da Criança. Hospital das Clínicas, São Paulo, SP, Brasil.Hospital São Paulo. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Instituto da Criança. Hospital das Clínicas, São Paulo, SP, Brasil.Maternidade Estadual Menino Jesus. São Paulo, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Instituto Materno Infantil Pernambuco. Recife, PE Brasil.Universidade Estadual de Campinas. Campinas, SP, Brasil.Funfarme. São José do Rio Preto, SP, Brasil.Hospital for Sick Children. The Motherisk Program. Toronto, Canadá.Universidade do Rio de Janeiro. Instituto National do Câncer. Unidade de Genética. Rio de Janeiro, RJ, Brasil.engPrenatal exposure to misoprostol and vascular disruption defects: a case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVascular DisruptionMoebius sequenceLimb DefectMisoprostolAnormalidades Induzidas por Medicamentos - fisiopatologiaAbortivos não Esteróides - efeitos adversosFeto - irrigação sanguíneaMisoprostol - efeitos adversosEfeitos Tardios da Exposição Pré-NatalGravidezinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPrenatal exposure to misoprostol.pdfapplication/pdf83469https://www.arca.fiocruz.br/bitstream/icict/210/1/Prenatal%20exposure%20to%20misoprostol.pdfb5a75bab289a9434c882199d2912fe0fMD51LICENSElicense.txttext/plain1878https://www.arca.fiocruz.br/bitstream/icict/210/2/license.txt4ab65ca798f15d32db061c8ec1b00ab1MD52TEXTPrenatal exposure to misoprostol.pdf.txtPrenatal exposure to misoprostol.pdf.txtExtracted texttext/plain21108https://www.arca.fiocruz.br/bitstream/icict/210/5/Prenatal%20exposure%20to%20misoprostol.pdf.txta3e41e73c66326fb8a0339b132bf0db3MD55THUMBNAILPrenatal exposure to misoprostol.pdf.jpgPrenatal exposure to misoprostol.pdf.jpgGenerated Thumbnailimage/jpeg2322https://www.arca.fiocruz.br/bitstream/icict/210/4/Prenatal%20exposure%20to%20misoprostol.pdf.jpge2ba59e2d0fff03e3c32c4cb32572ccaMD54icict/2102019-04-25 10:57:57.656oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-25T13:57:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
title |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
spellingShingle |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study Vargas, F. R. Vascular Disruption Moebius sequence Limb Defect Misoprostol Anormalidades Induzidas por Medicamentos - fisiopatologia Abortivos não Esteróides - efeitos adversos Feto - irrigação sanguínea Misoprostol - efeitos adversos Efeitos Tardios da Exposição Pré-Natal Gravidez |
title_short |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
title_full |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
title_fullStr |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
title_full_unstemmed |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
title_sort |
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study |
author |
Vargas, F. R. |
author_facet |
Vargas, F. R. Schuler-Faccini, L. Brunoni, D. Kim, C. Meloni, V. F. A. Sugayama, S. M. M. Albano, L. Llerena Junior, Juan Clinton Almeida, J. C. C. Duarte, A. Cavalcanti, D. P. Goloni-Bertollo, E. Conte, A. Koren, G. Addis, A. |
author_role |
author |
author2 |
Schuler-Faccini, L. Brunoni, D. Kim, C. Meloni, V. F. A. Sugayama, S. M. M. Albano, L. Llerena Junior, Juan Clinton Almeida, J. C. C. Duarte, A. Cavalcanti, D. P. Goloni-Bertollo, E. Conte, A. Koren, G. Addis, A. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vargas, F. R. Schuler-Faccini, L. Brunoni, D. Kim, C. Meloni, V. F. A. Sugayama, S. M. M. Albano, L. Llerena Junior, Juan Clinton Almeida, J. C. C. Duarte, A. Cavalcanti, D. P. Goloni-Bertollo, E. Conte, A. Koren, G. Addis, A. |
dc.subject.en.none.fl_str_mv |
Vascular Disruption Moebius sequence Limb Defect Misoprostol |
topic |
Vascular Disruption Moebius sequence Limb Defect Misoprostol Anormalidades Induzidas por Medicamentos - fisiopatologia Abortivos não Esteróides - efeitos adversos Feto - irrigação sanguínea Misoprostol - efeitos adversos Efeitos Tardios da Exposição Pré-Natal Gravidez |
dc.subject.decs.none.fl_str_mv |
Anormalidades Induzidas por Medicamentos - fisiopatologia Abortivos não Esteróides - efeitos adversos Feto - irrigação sanguínea Misoprostol - efeitos adversos Efeitos Tardios da Exposição Pré-Natal Gravidez |
description |
Prenatal exposure to misoprostol has beenassociated with Moebius and limb defects.Vascular disruption has been proposed asthe mechanism for these teratogenic effects. The present study is a multicenter, casecontrol study that was designed to compare the frequency of prenatal misoprostol use between mothers of Brazilian children diagnosedwith vascular disruption defects andmatched control mothers of children diagnosed with other types of defects. A total of 93 cases and 279 controls were recruited in eight participating centers. Prenatal exposure was identified in 32 infants diagnosed with vascular disruption defects (34.4 percent) compared with only 12 (4.3 percent) in the control group (P menor que 0.0000001). Our data suggest thatprenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2010-08-23T16:00:16Z |
dc.date.available.fl_str_mv |
2010-08-23T16:00:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VARGAS, F. R. et al. Prenatal exposure to misoprostol and vascular disruption defects: a case-control study. Am. J. Med. Genet., New York, v. 95, n. 4, p. 302-306, dec. 2000. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/210 |
dc.identifier.issn.pt_BR.fl_str_mv |
0148-7299 |
identifier_str_mv |
VARGAS, F. R. et al. Prenatal exposure to misoprostol and vascular disruption defects: a case-control study. Am. J. Med. Genet., New York, v. 95, n. 4, p. 302-306, dec. 2000. 0148-7299 |
url |
https://www.arca.fiocruz.br/handle/icict/210 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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