Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil

Tschá, Marcel Kruchelski; Suzukawa, Andréia Akemi; Rodrigues-Luiz, Gabriela Flavia; Silva, Allan Martins da; Cataneo, Allan Henrique Depieri; Coelho, Gabriela Mattoso; Ferreira, Adão Celestino; Medeiros, Lia Carolina Soares; Mansur, Daniel; Zanluca, Camila; Santos, Claudia Nunes Duarte dos

Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil

Detalhes bibliográficos
Autor(a) principal:	Tschá, Marcel Kruchelski
Data de Publicação:	2022
Outros Autores:	Suzukawa, Andréia Akemi, Rodrigues-Luiz, Gabriela Flavia, Silva, Allan Martins da, Cataneo, Allan Henrique Depieri, Coelho, Gabriela Mattoso, Ferreira, Adão Celestino, Medeiros, Lia Carolina Soares, Mansur, Daniel, Zanluca, Camila, Santos, Claudia Nunes Duarte dos
Tipo de documento:	Artigo
Idioma:	por
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/52604
Resumo:	Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.

Metadados do item

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spelling	Tschá, Marcel KruchelskiSuzukawa, Andréia AkemiRodrigues-Luiz, Gabriela FlaviaSilva, Allan Martins daCataneo, Allan Henrique DepieriCoelho, Gabriela MattosoFerreira, Adão CelestinoMedeiros, Lia Carolina SoaresMansur, DanielZanluca, CamilaSantos, Claudia Nunes Duarte dos2022-05-10T19:46:30Z2022-05-10T19:46:30Z2022TSCHÁ, Marcel Kruchelski et al. Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil. Virus Evolution, v. 7, n. 2, p. 1–14, 2022.2057-1577https://www.arca.fiocruz.br/handle/icict/5260410.1093/ve/veab105porOxford University PressAlphavirusTrichoprosoponWyeomyiaEncefalite Equina VenezuelanaArbovirusesPhylogenyCodonDinucleotide RepeatsEncephalomyelitis, Venezuelan EquineArbovirusFilogeniaRepeticiones de DinucleótidoEncefalomielitis Equina VenezolanaPhylogenèseRépétitions de dinucléotidesEncéphalomyélite équine du VénézuélaArbovírusFilogeniaCódonRepetições de DinucleotídeosCulicidaePirahy virus: identification of a new and potential emerging arbovirus in South Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil.Secretaria de Estado da Saúde do Paraná. Laboratório Cental. Paraná, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Secretaria de Estado da Saúde do Paraná. Núcleo de Entomologia de Foz do Iguaçu. Foz do Iguaçu, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brasil.Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Genomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus Alphavirus found in Trichoprosopon and Wyeomia mosquitoes, tentatively named Pirahy virus (PIRAV). PIRAV was isolated from mosquito pools collected in a rural area of Piraí do Sul, South Brazil. In vitro assays revealed that PIRAV replicates and causes cytopathic effects in vertebrate cell lines such as Vero E6, SH-SY5Y, BHK-21 and UMNSAH/DF-1. Genomic signature analysis supports these results showing a dinucleotide and codon usage balance compatible with several hosts. Phylogenetic analyses placed PIRAV basal to the Venezuelan equine encephalitis complex. Genome analyses, electron microscopy, and biological characterization show findings that may alert for the emergence of a new arbovirus in South America.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/52604/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALveab105OK.pdfveab105OK.pdfapplication/pdf3631177https://www.arca.fiocruz.br/bitstream/icict/52604/2/veab105OK.pdf65d512a1c24b6355340f9cab635fbbf4MD52icict/526042022-05-10 16:46:30.508oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-05-10T19:46:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
title	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
spellingShingle	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil Tschá, Marcel Kruchelski Alphavirus Trichoprosopon Wyeomyia Encefalite Equina Venezuelana Arboviruses Phylogeny Codon Dinucleotide Repeats Encephalomyelitis, Venezuelan Equine Arbovirus Filogenia Repeticiones de Dinucleótido Encefalomielitis Equina Venezolana Phylogenèse Répétitions de dinucléotides Encéphalomyélite équine du Vénézuéla Arbovírus Filogenia Códon Repetições de Dinucleotídeos Culicidae
title_short	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
title_full	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
title_fullStr	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
title_full_unstemmed	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
title_sort	Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil
author	Tschá, Marcel Kruchelski
author_facet	Tschá, Marcel Kruchelski Suzukawa, Andréia Akemi Rodrigues-Luiz, Gabriela Flavia Silva, Allan Martins da Cataneo, Allan Henrique Depieri Coelho, Gabriela Mattoso Ferreira, Adão Celestino Medeiros, Lia Carolina Soares Mansur, Daniel Zanluca, Camila Santos, Claudia Nunes Duarte dos
author_role	author
author2	Suzukawa, Andréia Akemi Rodrigues-Luiz, Gabriela Flavia Silva, Allan Martins da Cataneo, Allan Henrique Depieri Coelho, Gabriela Mattoso Ferreira, Adão Celestino Medeiros, Lia Carolina Soares Mansur, Daniel Zanluca, Camila Santos, Claudia Nunes Duarte dos
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Tschá, Marcel Kruchelski Suzukawa, Andréia Akemi Rodrigues-Luiz, Gabriela Flavia Silva, Allan Martins da Cataneo, Allan Henrique Depieri Coelho, Gabriela Mattoso Ferreira, Adão Celestino Medeiros, Lia Carolina Soares Mansur, Daniel Zanluca, Camila Santos, Claudia Nunes Duarte dos
dc.subject.other.pt_BR.fl_str_mv	Alphavirus Trichoprosopon Wyeomyia Encefalite Equina Venezuelana
topic	Alphavirus Trichoprosopon Wyeomyia Encefalite Equina Venezuelana Arboviruses Phylogeny Codon Dinucleotide Repeats Encephalomyelitis, Venezuelan Equine Arbovirus Filogenia Repeticiones de Dinucleótido Encefalomielitis Equina Venezolana Phylogenèse Répétitions de dinucléotides Encéphalomyélite équine du Vénézuéla Arbovírus Filogenia Códon Repetições de Dinucleotídeos Culicidae
dc.subject.en.pt_BR.fl_str_mv	Arboviruses Phylogeny Codon Dinucleotide Repeats Encephalomyelitis, Venezuelan Equine
dc.subject.es.pt_BR.fl_str_mv	Arbovirus Filogenia Repeticiones de Dinucleótido Encefalomielitis Equina Venezolana
dc.subject.fr.pt_BR.fl_str_mv	Phylogenèse Répétitions de dinucléotides Encéphalomyélite équine du Vénézuéla
dc.subject.decs.pt_BR.fl_str_mv	Arbovírus Filogenia Códon Repetições de Dinucleotídeos Culicidae
description	Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-05-10T19:46:30Z
dc.date.available.fl_str_mv	2022-05-10T19:46:30Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	TSCHÁ, Marcel Kruchelski et al. Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil. Virus Evolution, v. 7, n. 2, p. 1–14, 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/52604
dc.identifier.issn.pt_BR.fl_str_mv	2057-1577
dc.identifier.doi.none.fl_str_mv	10.1093/ve/veab105
identifier_str_mv	TSCHÁ, Marcel Kruchelski et al. Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil. Virus Evolution, v. 7, n. 2, p. 1–14, 2022. 2057-1577 10.1093/ve/veab105
url	https://www.arca.fiocruz.br/handle/icict/52604
dc.language.iso.fl_str_mv	por
language	por
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Oxford University Press
publisher.none.fl_str_mv	Oxford University Press
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/52604/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/52604/2/veab105OK.pdf
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil

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