Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes

Detalhes bibliográficos
Autor(a) principal: Carvalho, L. J. M.
Data de Publicação: 2000
Outros Autores: Lenzi, Henrique Leonel, Machado, Marcelo Pelajo, Oliveira, Denise N., Daniel-Ribeiro, Cláudio Tadeu, Cruz, Maria de Fátima Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5869
http://dx.doi.org/10.1006/expr.2000.4508
Resumo: The authors dedicate this paper in honor of the Instituto Oswaldo Cruz on the occasion of the Centenary of its foundation, May 25th, 1900. The authors are grateful to Bruno Silva Vale and Arturo Max Arana-Pino for processing images in scanning light confocal microscopy, to Isaac Lima da Silva Filho and Janete Cuba from Evandro Chagas Hospital–IOC–Fiocruz for hematological analysis, to Belmira Ferreira dos Santos from the Fiocruz Central Animal House for providing us with CBA/J mouse strain and to Dr. Heitor Franco Jr. (IMT–São Paulo, Brazil) for kindly providing the P. berghei ANKA strain. This work was supported by funds of the Conselho Nacional de Desenvolvimento Tecnológico (CNPq) and FAPERJ–Brazil.
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spelling Carvalho, L. J. M.Lenzi, Henrique LeonelMachado, Marcelo PelajoOliveira, Denise N.Daniel-Ribeiro, Cláudio TadeuCruz, Maria de Fátima Ferreira da2012-11-26T14:26:53Z2012-11-26T14:26:53Z2000CARVALHO, L. J. M. et al. Plasmodium berghei: cerebral malaria in CBA mice is not cleary related to plasma TNF levels or intensity of histopathological changes. Experimental Parasitology, v. 95, n.1, p. 1-7, 2000.0014-4894https://www.arca.fiocruz.br/handle/icict/5869http://dx.doi.org/10.1006/expr.2000.4508The authors dedicate this paper in honor of the Instituto Oswaldo Cruz on the occasion of the Centenary of its foundation, May 25th, 1900. The authors are grateful to Bruno Silva Vale and Arturo Max Arana-Pino for processing images in scanning light confocal microscopy, to Isaac Lima da Silva Filho and Janete Cuba from Evandro Chagas Hospital–IOC–Fiocruz for hematological analysis, to Belmira Ferreira dos Santos from the Fiocruz Central Animal House for providing us with CBA/J mouse strain and to Dr. Heitor Franco Jr. (IMT–São Paulo, Brazil) for kindly providing the P. berghei ANKA strain. This work was supported by funds of the Conselho Nacional de Desenvolvimento Tecnológico (CNPq) and FAPERJ–Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, BrasilPlasmodium berghei ANKA infection in CBA/J mice leads to the development of cerebral malaria (CM) that kills 80–90% of the animals in 6–9 days. This model has been used to study the pathogenesis of CM, which is a major cause of morbidity and mortality in Plasmodium falciparum-infected individuals. The role of cytokines in the induction of CM in the murine model has been well documented, but most studies have been restricted to the peak of neurological manifestations. Here we used a sequential approach to compare mice that developed CM with those that developed no cerebral pathology. Animals were examined for systemic histopathological changes and plasma Tumor Necrosis Factor-α (TNF) levels. The objectives were (a) to further determine the importance of factors commonly associated with murine CM—such as elevated levels of TNF and the presence of hemorrhage and vascular plugging—by comparing mice at different stages of infection and/or with different outcomes following infection and (b) to examine the importance of systemic changes—course of parasitemia and histopathological alterations in brain, liver, and lungs—in the development of CM. The data suggest that (a) the clinical manifestation of CM appears to be associated with a wave of merozoite release on days 6–7, (b) murine CM does not present reliable histopathological indicators, (c) there is no topographic association between the occurrence of intravascular plugging and the hemorrhagic foci, (d) monocyte–monocyte and monocyte–endothelial cell adherence were the most expressive histopathological events and were not restricted to brain vessels, (e) blood levels of TNF are not indicative of the local tissue reaction, (f) adhesiveness of monocyte/endothelial cells fluctuate during infection and is dissociated from the lymphocyte homing to the liver, and (g) pulmonary megakaryocytosis (megakaryopoiesis?) is a late event in the lungs.engElsevierPlasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlecerebral malaria (CM)lasmodium berghei ANKACBA/J miceumor Necrosis Factor-α (TNF)cytokinesmerozoite releasehemorrhageshistopathologyintercellular cell adhesion molecule-1 (ICAM-1)lymphocyte function antigen-1 (LFA-1)EncéfaloFígadoLungMalária CerebralPlasmodium bergheiFator de Necrose Tumoral alfainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
title Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
spellingShingle Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
Carvalho, L. J. M.
cerebral malaria (CM)
lasmodium berghei ANKA
CBA/J mice
umor Necrosis Factor-α (TNF)
cytokines
merozoite release
hemorrhages
histopathology
intercellular cell adhesion molecule-1 (ICAM-1)
lymphocyte function antigen-1 (LFA-1)
Encéfalo
Fígado
Lung
Malária Cerebral
Plasmodium berghei
Fator de Necrose Tumoral alfa
title_short Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
title_full Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
title_fullStr Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
title_full_unstemmed Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
title_sort Plasmodium berghei: cerebral malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes
author Carvalho, L. J. M.
author_facet Carvalho, L. J. M.
Lenzi, Henrique Leonel
Machado, Marcelo Pelajo
Oliveira, Denise N.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Lenzi, Henrique Leonel
Machado, Marcelo Pelajo
Oliveira, Denise N.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, L. J. M.
Lenzi, Henrique Leonel
Machado, Marcelo Pelajo
Oliveira, Denise N.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
dc.subject.en.pt_BR.fl_str_mv cerebral malaria (CM)
lasmodium berghei ANKA
CBA/J mice
umor Necrosis Factor-α (TNF)
cytokines
merozoite release
hemorrhages
histopathology
intercellular cell adhesion molecule-1 (ICAM-1)
lymphocyte function antigen-1 (LFA-1)
topic cerebral malaria (CM)
lasmodium berghei ANKA
CBA/J mice
umor Necrosis Factor-α (TNF)
cytokines
merozoite release
hemorrhages
histopathology
intercellular cell adhesion molecule-1 (ICAM-1)
lymphocyte function antigen-1 (LFA-1)
Encéfalo
Fígado
Lung
Malária Cerebral
Plasmodium berghei
Fator de Necrose Tumoral alfa
dc.subject.decs.pt_BR.fl_str_mv Encéfalo
Fígado
Lung
Malária Cerebral
Plasmodium berghei
Fator de Necrose Tumoral alfa
description The authors dedicate this paper in honor of the Instituto Oswaldo Cruz on the occasion of the Centenary of its foundation, May 25th, 1900. The authors are grateful to Bruno Silva Vale and Arturo Max Arana-Pino for processing images in scanning light confocal microscopy, to Isaac Lima da Silva Filho and Janete Cuba from Evandro Chagas Hospital–IOC–Fiocruz for hematological analysis, to Belmira Ferreira dos Santos from the Fiocruz Central Animal House for providing us with CBA/J mouse strain and to Dr. Heitor Franco Jr. (IMT–São Paulo, Brazil) for kindly providing the P. berghei ANKA strain. This work was supported by funds of the Conselho Nacional de Desenvolvimento Tecnológico (CNPq) and FAPERJ–Brazil.
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2012-11-26T14:26:53Z
dc.date.available.fl_str_mv 2012-11-26T14:26:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CARVALHO, L. J. M. et al. Plasmodium berghei: cerebral malaria in CBA mice is not cleary related to plasma TNF levels or intensity of histopathological changes. Experimental Parasitology, v. 95, n.1, p. 1-7, 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5869
dc.identifier.issn.none.fl_str_mv 0014-4894
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1006/expr.2000.4508
identifier_str_mv CARVALHO, L. J. M. et al. Plasmodium berghei: cerebral malaria in CBA mice is not cleary related to plasma TNF levels or intensity of histopathological changes. Experimental Parasitology, v. 95, n.1, p. 1-7, 2000.
0014-4894
url https://www.arca.fiocruz.br/handle/icict/5869
http://dx.doi.org/10.1006/expr.2000.4508
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dc.publisher.none.fl_str_mv Elsevier
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