Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16044 |
Resumo: | Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico, Brazil (CNPq, 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nıvel Superior (CAPES), Fundação Araucaria (Convênio 419/2009) |
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Malvezi, Aparecida DonizetteSilva, Rosiane Valeriano daPanis, CarolinaYamauchi, Lucy MegumiLovo-Martins, Maria IsabelZanluqui, Nágela GhabdanTatakihara, Vera Lúcia HidekoRizzo, Luiz VicenteVerri Jr, Waldiceu AparecidoMartins-Pinge, Marli CardosoYamada-Ogatta, Sueli FumiePinge-Filho, Phileno2016-10-03T14:38:13Z2016-10-03T14:38:13Z2014MALVEZI, Aparecida Donizette et al. Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages. Mediators of Inflammation, v. 2014, p. 1-9, 2014.0962-9351https://www.arca.fiocruz.br/handle/icict/1604410.1155/2014/580919Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico, Brazil (CNPq, 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nıvel Superior (CAPES), Fundação Araucaria (Convênio 419/2009)Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.0 Londrina, PR, BrazilUniversidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia Molecular de Microrganismos. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.Instituto Israelita de Ensino e Pesquisa Albert Einstein. São Paulo, SP, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Fisiológicas. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia Molecular de Microrganismos. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.The intracellular protozoan parasite Trypanosoma cruzi causes Chagas disease, a serious disorder that affects millions of people in Latin America. Cell invasion by T. cruzi and its intracellular replication are essential to the parasite's life cycle and for the development of Chagas disease. Here, we present evidence suggesting the involvement of the host's cyclooxygenase (COX) enzyme during T. cruzi invasion. Pharmacological antagonist for COX-1, aspirin (ASA), caused marked inhibition of T. cruzi infection when peritoneal macrophages were pretreated with ASA for 30 min at 37°C before inoculation. This inhibition was associated with increased production of IL-1β and nitric oxide (NO(∙)) by macrophages. The treatment of macrophages with either NOS inhibitors or prostaglandin E2 (PGE2) restored the invasive action of T. cruzi in macrophages previously treated with ASA. Lipoxin ALX-receptor antagonist Boc2 reversed the inhibitory effect of ASA on trypomastigote invasion. Our results indicate that PGE2, NO(∙), and lipoxins are involved in the regulation of anti-T. cruzi activity by macrophages, providing a better understanding of the role of prostaglandins in innate inflammatory response to T. cruzi infection as well as adding a new perspective to specific immune interventions.engMarcelo T. BozzaAspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTrypanosoma cruziiNOSAspirinAnti-Infective AgentsAnti-Infecciososinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16044/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALAspirin modulates innate inflammatory response.pdfAspirin modulates innate inflammatory response.pdfapplication/pdf1158424https://www.arca.fiocruz.br/bitstream/icict/16044/2/Aspirin%20modulates%20innate%20inflammatory%20response.pdfead857b84f8a12d3e17fae52cab3ea3aMD52TEXTAspirin modulates innate inflammatory response.pdf.txtAspirin modulates innate inflammatory response.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| title |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| spellingShingle |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages Malvezi, Aparecida Donizette Trypanosoma cruzi iNOS Aspirin Anti-Infective Agents Anti-Infecciosos |
| title_short |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| title_full |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| title_fullStr |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| title_full_unstemmed |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| title_sort |
Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages |
| author |
Malvezi, Aparecida Donizette |
| author_facet |
Malvezi, Aparecida Donizette Silva, Rosiane Valeriano da Panis, Carolina Yamauchi, Lucy Megumi Lovo-Martins, Maria Isabel Zanluqui, Nágela Ghabdan Tatakihara, Vera Lúcia Hideko Rizzo, Luiz Vicente Verri Jr, Waldiceu Aparecido Martins-Pinge, Marli Cardoso Yamada-Ogatta, Sueli Fumie Pinge-Filho, Phileno |
| author_role |
author |
| author2 |
Silva, Rosiane Valeriano da Panis, Carolina Yamauchi, Lucy Megumi Lovo-Martins, Maria Isabel Zanluqui, Nágela Ghabdan Tatakihara, Vera Lúcia Hideko Rizzo, Luiz Vicente Verri Jr, Waldiceu Aparecido Martins-Pinge, Marli Cardoso Yamada-Ogatta, Sueli Fumie Pinge-Filho, Phileno |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Malvezi, Aparecida Donizette Silva, Rosiane Valeriano da Panis, Carolina Yamauchi, Lucy Megumi Lovo-Martins, Maria Isabel Zanluqui, Nágela Ghabdan Tatakihara, Vera Lúcia Hideko Rizzo, Luiz Vicente Verri Jr, Waldiceu Aparecido Martins-Pinge, Marli Cardoso Yamada-Ogatta, Sueli Fumie Pinge-Filho, Phileno |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi iNOS Aspirin |
| topic |
Trypanosoma cruzi iNOS Aspirin Anti-Infective Agents Anti-Infecciosos |
| dc.subject.en.En.fl_str_mv |
Anti-Infective Agents |
| dc.subject.decs.pt_BR.fl_str_mv |
Anti-Infecciosos |
| description |
Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico, Brazil (CNPq, 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nıvel Superior (CAPES), Fundação Araucaria (Convênio 419/2009) |
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2014 |
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2014 |
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2016-10-03T14:38:13Z |
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2016-10-03T14:38:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MALVEZI, Aparecida Donizette et al. Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages. Mediators of Inflammation, v. 2014, p. 1-9, 2014. |
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https://www.arca.fiocruz.br/handle/icict/16044 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0962-9351 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1155/2014/580919 |
| identifier_str_mv |
MALVEZI, Aparecida Donizette et al. Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages. Mediators of Inflammation, v. 2014, p. 1-9, 2014. 0962-9351 10.1155/2014/580919 |
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eng |
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openAccess |
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Marcelo T. Bozza |
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Marcelo T. Bozza |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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