Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30501 |
Resumo: | Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Universidade Federal Rural do Semi-Árido. Mossoró, RN, Brasil. |
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Câmara, C. C.Oriá, R. B.Felismino, T. C.Silva, A. P. daSilva, M. A. M. daAlcântara, J. V. A.Costa, S. B. C.Vicente, A. C. P.Santos, T. J. TeixeiraCosta, C. M. de Castro2018-12-11T11:27:57Z2018-12-11T11:27:57Z2010CÂMARA, C. C. et al. Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells. Brazilian Journal of Medical and Biological Research, v. 43, p.657-662, 2010.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/3050110.1590/S0100-879X20100075000501414-431XengAssociação Brasileira de Divulgação CientíficaMielite experimentalCélulas MT2 infectadas pelo HTLV-1Comportamentos motoresMotor behaviorsHTLV-1-infected MT2 cellsWistar ratsExperimental myelopathyMieliteRatos WistarMotor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Universidade Federal Rural do Semi-Árido. Mossoró, RN, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Institutos Nacionais de Ciência e Tecnologia. Instituto de Biomedicina do Semiárido Brasileiro. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Institutos Nacionais de Ciência e Tecnologia. Instituto de Biomedicina do Semiárido Brasileiro. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Institutos Nacionais de Ciência e Tecnologia. Instituto de Biomedicina do Semiárido Brasileiro. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Institutos Nacionais de Ciência e Tecnologia. Instituto de Biomedicina do Semiárido Brasileiro. Fortaleza, CE, BrasilThe objective of the present study was to describe motor behavioral changes in association with histopathological and hematological findings in Wistar rats inoculated intravenously with human T-cell lymphotropic virus type 1 (HTLV-1)-infected MT2 cells. Twenty-five 4-month-old male rats were inoculated with HTLV-1-infected MT2 cells and 13 control rats were inoculated with normal human lymphocytes. The behavior of the rats was observed before and 5, 10, 15, and 20 months after inoculation during a 30-min/rat testing time for 5 consecutive days. During each of 4 periods, a subset of rats was randomly chosen to be sacrificed in order to harvest the spinal cord for histopathological analysis and to obtain blood for serological and molecular studies. Behavioral analyses of the HTLV-1-inoculated rats showed a significant decrease of climbing, walking and freezing, and an increase of scratching, sniffing, biting, licking, and resting/sleeping. Two of the 25 HTLV-1-inoculated rats (8%) developed spastic paraparesis as a major behavioral change. The histopathological changes were few and mild, but in some cases there was diffuse lymphocyte infiltration. The minor and major behavioral changes occurred after 10-20 months of evolution. The long-term observation of Wistar rats inoculated with HTLV-1-infected MT2 cells showed major (spastic paraparesis) and minor motor abnormalities in association with the degree of HTLV-1-induced myelopathy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30501/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALACP_vicente_etal_IOC_2010.pdfACP_vicente_etal_IOC_2010.pdfapplication/pdf986160https://www.arca.fiocruz.br/bitstream/icict/30501/2/ACP_vicente_etal_IOC_2010.pdf6ade2c48f3217da71bf6fe51b6765e23MD52TEXTACP_vicente_etal_IOC_2010.pdf.txtACP_vicente_etal_IOC_2010.pdf.txtExtracted texttext/plain27442https://www.arca.fiocruz.br/bitstream/icict/30501/3/ACP_vicente_etal_IOC_2010.pdf.txt2be235d6e386118c9001ef388da11a02MD53icict/305012018-12-12 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| dc.title.pt_BR.fl_str_mv |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| title |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| spellingShingle |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells Câmara, C. C. Mielite experimental Células MT2 infectadas pelo HTLV-1 Comportamentos motores Motor behaviors HTLV-1-infected MT2 cells Wistar rats Experimental myelopathy Mielite Ratos Wistar |
| title_short |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| title_full |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| title_fullStr |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| title_full_unstemmed |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| title_sort |
Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells |
| author |
Câmara, C. C. |
| author_facet |
Câmara, C. C. Oriá, R. B. Felismino, T. C. Silva, A. P. da Silva, M. A. M. da Alcântara, J. V. A. Costa, S. B. C. Vicente, A. C. P. Santos, T. J. Teixeira Costa, C. M. de Castro |
| author_role |
author |
| author2 |
Oriá, R. B. Felismino, T. C. Silva, A. P. da Silva, M. A. M. da Alcântara, J. V. A. Costa, S. B. C. Vicente, A. C. P. Santos, T. J. Teixeira Costa, C. M. de Castro |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Câmara, C. C. Oriá, R. B. Felismino, T. C. Silva, A. P. da Silva, M. A. M. da Alcântara, J. V. A. Costa, S. B. C. Vicente, A. C. P. Santos, T. J. Teixeira Costa, C. M. de Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Mielite experimental Células MT2 infectadas pelo HTLV-1 Comportamentos motores |
| topic |
Mielite experimental Células MT2 infectadas pelo HTLV-1 Comportamentos motores Motor behaviors HTLV-1-infected MT2 cells Wistar rats Experimental myelopathy Mielite Ratos Wistar |
| dc.subject.en.pt_BR.fl_str_mv |
Motor behaviors HTLV-1-infected MT2 cells Wistar rats Experimental myelopathy |
| dc.subject.decs.pt_BR.fl_str_mv |
Mielite Ratos Wistar |
| description |
Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Laboratório de Neurologia Experimental e Neurofisiologia. Fortaleza, CE, Brasil / Universidade Federal Rural do Semi-Árido. Mossoró, RN, Brasil. |
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2010 |
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2010 |
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2018-12-11T11:27:57Z |
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2018-12-11T11:27:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
CÂMARA, C. C. et al. Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells. Brazilian Journal of Medical and Biological Research, v. 43, p.657-662, 2010. |
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https://www.arca.fiocruz.br/handle/icict/30501 |
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0100-879X |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2010007500050 |
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1414-431X |
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CÂMARA, C. C. et al. Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells. Brazilian Journal of Medical and Biological Research, v. 43, p.657-662, 2010. 0100-879X 10.1590/S0100-879X2010007500050 1414-431X |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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